Abstract:The principle of substance stability -the feedback principle -is applicable to all biological systems. It boils down for different temporal hierarchies to the following: during the formation (self-assembly) of the most thermodynamically stable structures at the highest hierarchical level (j), e.g., the supramolecular level, in accordance with the second law, Nature spontaneously uses predominantly the (available for the given local part of the biological system) least thermodynamically stable structures belonging to a lower level, for example, the molecular level (j-1). The principle can be also applied to understructure hierarchical levels of any temporal hierarchy. It helps in understanding the causes of cancer formation and the origin of some other diseases.