Why do young women smoke? VII COMT as a risk modifying gene for Nicotine dependence – role of gene–gene interaction, personality, and environmental factors

Greenbaum, Lior; Kanyas, Kyra; Rigbi, Amihai; Alkelai, Anna; Kohn, Yoav; Lerer, Bernard

doi:10.1002/hup.1149

Cited by 8 publications

(10 citation statements)

References 33 publications

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“…While this location suggests that this polymorphism has a regulatory function and may affect COMT expression, 65 we found no support for nearby regulatory regions when the ENCODE data were reviewed. Only three studies have reported significant associations between COMT rs9332377 and clinical phenotypes (i.e., hearing loss, 66 suicidal ideation, 67 nicotine dependence 65 ). No studies have evaluated for associations between COMT rs9332377 and fatigue.…”

Section: Discussioncontrasting

confidence: 68%

Associations Between Neurotransmitter Genes and Fatigue and Energy Levels in Women After Breast Cancer Surgery

Eshragh

Dhruva

Paul

et al. 2017

Journal of Pain and Symptom Management

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Context Fatigue is a common problem in oncology patients. Less is known about decrements in energy levels and the mechanisms that underlie both fatigue and energy. Objectives In patients with breast cancer, variations in neurotransmitter genes between Lower and Higher Fatigue latent classes and between the Higher and Lower Energy latent classes were evaluated. Methods Patients completed assessments prior to and monthly for 6 months following surgery. Growth mixture modeling was used to identify distinct latent classes for fatigue severity and energy levels. Thirty candidate genes involved in various aspects of neurotransmission were evaluated. Results Eleven single nucleotide polymorphisms (SNPs) or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327 and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. Seven SNPs or haplotypes (i.e., NOS1 rs471871, SLC6A1 rs2675163, SLC6A1 Haplotype D01, SLC6A2 rs36027, SLC6A3 rs37022, SLC6A4 rs2020942, and TAC1 rs2072100) were associated with latent class membership for energy. Three of thirteen genes (i.e., NOS1, SLC6A2, SLC6A4) were associated with latent class membership for both fatigue and energy. Conclusions Molecular findings support the hypothesis that fatigue and energy are distinct, yet related symptoms. Results suggest that a large number of neurotransmitters play a role in the development and maintenance of fatigue and energy levels in breast cancer patients.

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Section: Discussioncontrasting

confidence: 68%

Associations Between Neurotransmitter Genes and Fatigue and Energy Levels in Women After Breast Cancer Surgery

Eshragh

Dhruva

Paul

et al. 2017

Journal of Pain and Symptom Management

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“…Greenbaum et al found smokers with A allele of rs660652 had a higher risk for nicotine dependence, which may result in more difficulty to quit. In contrast, Erlich et al revealed smokers with G allele of rs660652 were more serious of nicotine dependence and less probability of attempts to quit .…”

Section: Discussionmentioning

confidence: 99%

Relative contribution of genetic, individual, and self-efficacy factors to smoking cessation in a Chinese rural population

Wang

et al. 2017

Am J Addict

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“…Additionally, mother's lifetime smoking may transmit separate genetic risks than does MSP, since specific genetic factors influence different aspects of smoking independently (Maes et al, 2004). In particular, genetic factors associated smoking initiation (Kendler et al, 1999;Koopmans et al, 1999), risk-taking/disinhibited behavior (Hopfer, Crowley, & Hewitt, 2003;Keyes, Legrand, Iacono, & McGue, 2008), or ND (Greenbaum et al, 2010;O'Loughlin et al, 2004;Weiss et al, 2008) may partially explain the effects of mother's lifetime smoking on adolescent smoking frequency and ND.…”

Section: Discussionmentioning

confidence: 99%

Exploring Alternate Processes Contributing to the Association Between Maternal Smoking and the Smoking Behavior Among Young Adult Offspring

Selya¹,

Wakschlag²,

Dierker³

et al. 2013

Nicotine & Tobacco Research

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introduction: Maternal smoking during pregnancy (MSP) is a known risk factor for regular smoking in young adulthood and may pose a risk independently of mother's lifetime smoking. The processes through which MSP exerts this influence are unknown but may occur through greater smoking quantity and frequency following initiation early in adolescence or increased sensitivity to nicotine dependence (ND) at low levels of smoking.

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Why do young women smoke? VII COMT as a risk modifying gene for Nicotine dependence – role of gene–gene interaction, personality, and environmental factors

Cited by 8 publications

References 33 publications

Associations Between Neurotransmitter Genes and Fatigue and Energy Levels in Women After Breast Cancer Surgery

Associations Between Neurotransmitter Genes and Fatigue and Energy Levels in Women After Breast Cancer Surgery

Relative contribution of genetic, individual, and self-efficacy factors to smoking cessation in a Chinese rural population

Exploring Alternate Processes Contributing to the Association Between Maternal Smoking and the Smoking Behavior Among Young Adult Offspring

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