Why do the majority of patients not respond at all, or only partially or transiently, to immunotherapy?

Dalgleish, Angus

doi:10.1080/14737140.2019.1696676

Cited by 2 publications

(1 citation statement)

References 18 publications

(18 reference statements)

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“…We found that one of the tumor models we selected, lymphosarcoma RLS40, did not respond to isRNA complexes with the studied liposomes ( Figure 7 ), and it did not activate expression of the immune response marker Pkr ( Figure 6 ). This situation reflects the situation that exists in clinics, where there are “responders” and “non-responders” to certain types of treatment of the tumor [ 56 ]. The reason for this in this case was not determined in this study; it is probably associated with both the tissue origin of tumor cells and the less effective accumulation of isRNA complexes in them ( Figure 5 ).…”

Section: Discussionmentioning

confidence: 76%

Influence of the Composition of Cationic Liposomes on the Performance of Cargo Immunostimulatory RNA

Bishani,

Makarova,

Shmendel

et al. 2023

Pharmaceutics

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In this study, the impact of different delivery systems on the cytokine-inducing, antiproliferative, and antitumor activities of short immunostimulatory double-stranded RNA (isRNA) was investigated. The delivery systems, consisting of the polycationic amphiphile 1,26-bis(cholest-5-en-3-yloxycarbonylamino)-7,11,16,20 tetraazahexacosan tetrahydrochloride (2X3), and the lipid-helper dioleoylphosphatidylethanolamine (DOPE), were equipped with polyethylene glycol lipoconjugates differing in molecular weight and structure. The main findings of this work are as follows: (i) significant activation of MCP-1 and INF-α, β, and γ production in CBA mice occurs under the action of isRNA complexes with liposomes containing lipoconjugates with long PEG chains, while activation of MCP-1 and INF-γ, but not INF-α or β, was observed under the action of isRNA lipoplexes containing lipoconjugates with short PEG chains; (ii) a pronounced antiproliferative effect on B16 melanoma cells in vitro, as well as an antitumor and hepatoprotective effect in vivo, was induced by isRNA pre-complexes with non-pegylated liposomes, while complexes containing lipoconjugates with long-chain liposomes were inactive; (iii) the antitumor activity of isRNA correlated with the efficiency of its accumulation in the cells and did not explicitly depend on the activation of cytokine and interferon production. Thus, the structure of the delivery system plays a vital role in determining the response to isRNA and allows for the choice of a delivery system depending on the desired effect.

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Section: Discussionmentioning

confidence: 76%

Influence of the Composition of Cationic Liposomes on the Performance of Cargo Immunostimulatory RNA

Bishani,

Makarova,

Shmendel

et al. 2023

Pharmaceutics

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Recent advances of immunotherapy for biliary tract cancer

Rizzo

Ricci

Brandi

2021

Expert Review of Gastroenterology & Hepatology

102

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Article Highlights• Cholangiocarcinoma (CCA) is a rare malignancy with overall poor prognosis • There are limited options regarding systemic treatment for CCA, with combination chemotherapy regimens achieving limited responses so far • In the past few years, immunotherapy has revolutionized the treatment landscape of several hematologic and solid tumors• Single agent immune checkpoint inhibitors have reported controversial results in CCA, suggesting modest but real responses in a limited subset of patients• Novel combination strategies with immune checkpoint inhibitors are currently being explored in this setting, with a view to provide more effective treatment options in advanced CCA.

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Why do the majority of patients not respond at all, or only partially or transiently, to immunotherapy?

Cited by 2 publications

References 18 publications

Influence of the Composition of Cationic Liposomes on the Performance of Cargo Immunostimulatory RNA

Influence of the Composition of Cationic Liposomes on the Performance of Cargo Immunostimulatory RNA

Recent advances of immunotherapy for biliary tract cancer

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