Why Do Low-Fat High-Carbohydrate Diets Accentuate Postprandial Lipemia in Patients With NIDDM?

Chen, Y-D. Ida; Coulston, Ann M.; Zhou, Mingyue; Hollenbeck, C. B.; Reaven, Gerald M.

doi:10.2337/diacare.18.1.10

Cited by 111 publications

(64 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In randomized crossover feeding trials among healthy subjects, increasing total carbohydrate intake, in an amount equivalent to going from the lowest to the highest quintile of intake in this study population, increased post-prandial insulin response to test meals after a few days on this diet as well as day-long insulin and glucose concentrations after 3 weeks of following this diet (Jeppesen et al, 1997). Similar effects have been observed in type 2 diabetics (Garg et al, 1994;Chen et al, 1995) PCOS women (Douglas et al, 2006a) and hypertriglyceridemic individuals . Low-glycemic index diets significantly decrease HbA1c levels and improve insulin sensitivity among diabetics (Brand-Miller et al, 2003;Jimenez-Cruz et al, 2003;Rizkalla et al, 2004), women with impaired glucose tolerance (Ostman et al, 2006) and are related to fasting glucose and HbA1c levels among healthy women (Murakami et al, 2006).…”

Section: Discussionsupporting

confidence: 58%

A prospective study of dietary carbohydrate quantity and quality in relation to risk of ovulatory infertility

et al. 2007

View full text Add to dashboard Cite

Objective: To evaluate whether the amount or quality of carbohydrate in diet is associated with ovulatory infertility. Subjects and Methods: In total, 18 555 married, premenopausal women without a history of infertility were followed as they attempted a pregnancy or became pregnant during an 8-year period. Diet was assessed two times during follow-up using a validated food-frequency questionnaire and prospectively related to the incidence of infertility due ovulatory disorder. Results: During follow-up, 438 women reported ovulatory infertility. Total carbohydrate intake and dietary glycemic load were positively related to ovulatory infertility in analyses adjusted for age, body mass index, smoking, parity, physical activity, recency of contraception, total energy intake, protein intake and other dietary variables. The multivariable-adjusted risk ratio (RR) (95% confidence interval (CI)) of ovulatory infertility comparing the highest-to-lowest quintile of total carbohydrate intake was 1.91 (1.27-3.02). The corresponding RR (95% CI) for dietary glycemic load was 1.92 (1.26-2.92). Dietary glycemic index was positively related to ovulatory infertility only among nulliparous women. Intakes of fiber from different sources were unrelated to ovulatory infertility risk. Conclusions:The amount and quality of carbohydrate in diet may be important determinants of ovulation and fertility in healthy women.

show abstract

Section: Discussionsupporting

confidence: 58%

A prospective study of dietary carbohydrate quantity and quality in relation to risk of ovulatory infertility

et al. 2007

View full text Add to dashboard Cite

show abstract

“…This concept fits well with the relationship already observed between fasting insulinemia (and thus related postprandial hyperinsulinemia) and postprandial TG response (5,14,15). It is also noteworthy to emphasize that low-fat, highly digestible carbohydrate diets are known to induce hyperinsulinism as well as fasting and postprandial hyperlipidemia (41,42). It has been confirmed that this kind of diet induces a significant decrease in TRL clearance in normal subjects, with the presence of apoB-48-containing TRLs in the fasting state illustrating a delay in the clearance of these particles (43), in line with other data (5,9).…”

Section: A Harbis and Associatessupporting

confidence: 60%

Acute Hyperinsulinism Modulates Plasma Apolipoprotein B-48 Triglyceride--Rich Lipoproteins in Healthy Subjects During the Postprandial Period

Harbis¹,

Defoort²,

Narbonne³

et al. 2001

Diabetes

View full text Add to dashboard Cite

The role of postprandial insulin in the regulation of postprandial lipid metabolism is still poorly understood. The roles of hyperinsulinemia and insulin resistance in the alteration of postprandial lipid metabolism are not clear either. To improve knowledge in this area, we submitted healthy men to acute hyperinsulinemia in two different ways. In the first study, we compared in 10 men the effects of four isolipidic test meals that induce different degrees of hyperinsulinemia on postprandial lipid metabolism. Three different carbohydrate sources were compared according to their glycemic indexes (GIs; 35, 75, and 100 for white kidney bean, spaghetti, and white bread test meals, respectively); the fourth test meal did not contain any carbohydrates. Postprandial plasma insulin levels were proportional to the GIs (maximal plasma insulin concentrations: 113 ± 16 to 266 ± 36 pmol/l). We found a strong positive correlation during the 6-h postprandial period between apolipoprotein (apo) B-48 plasma concentration and insulin plasma concentration (r 2 = 0.70; P = 0.0001). In a second study, 5 of the 10 subjects again ingested the carbohydrate-free meal, but during a 3-h hyperinsulinemic-(550 ± 145 pmol/l plasma insulin) euglycemic (5.5 ± 0.8 mmol/l plasma glucose) clamp. A biphasic response was observed with markedly reduced levels of plasma apoB-48 during insulin infusion, followed by a late accumulation of plasma apoB-48 and triglycerides. Overall, the data obtained showed that portal and peripheral hyperinsulinism delays and exacerbates postprandial accumulation of intestinally derived chylomicrons in plasma and thus is involved in the regulation of apoB-48-triglyceride-rich lipoprotein metabolism, in the absence of insulin-resistance syndrome. Diabetes 50:462-469, 2001

show abstract

“…In the current study we used a so-called 'cafeteria-style' diet to induce insulin resistance in rats. cafeteria-style diet enhances fat delivery to skeletal muscles both directly by increased dietary fat content and indirectly by sucrose-induced stimulation of hepatic lipogenesis (30,48). In the current study, fasted serum triglyceride concentrations were increased~3-fold within three weeks of cafeteria-style diet (data not shown).…”

Section: Discussionmentioning

confidence: 61%

Hyperglycemic diet and training alter insulin sensitivity, intramyocellular lipid content but not UCP3 protein expression in rat skeletal muscles

Vaisy

Szlufcik²,

Maris³

et al. 2010

Int J Mol Med

View full text Add to dashboard Cite

Abstract. Intramyocellular lipids (IMCL) and mitochondrial uncoupling protein-3 (UCP3) have been implicated in the development of muscular insulin resistance. This study aimed to investigate the role of IMCL and UCP3 in the development of glucose intolerance and muscular insulin resistance during 12 weeks of an obesity-inducing 'cafeteria-style' diet alone (CAF), or in conjunction with exercise training from weeks 8-12 (CAF TR ), in rats. At the end of the intervention period, gain in body weight was 20% higher in CAF (305±10 g) than controls (CON) (255±14 g; p<0.001) and CAF TR (253±7 g; p<0.001). Furthermore, compared with CON, the Matsuda insulin sensitivity index (ISI), assessed during a 2-h intravenous glucose tolerance test, was markedly lower in CAF (6.7±0.4) than in either CON (15.6±1.4; p<0.001) or CAF TR (11.2±1.1; p<0.001). Moreover, in CAF glucose transport at a submaximal insulin concentration (200 μU/ml) was reduced by ~60% (p<0.05) in both red and white gastrocnemius muscles, but not in m. soleus. However, glucose transport in CAF TR was similar to CON in red gastrocnemius. In CAF fiber-specific IMCL content determined in m. soleus and extensor digitorum longus (EDL), was higher than in CON (p<0.01) and CAF TR (p<0.001). Muscle UCP3 protein content was not changed by any of the interventions. Interestingly, within CAF and CAF TR , ISI closely negatively correlated with IMCL content in both type I (soleus, r=-0.93; EDL, r=-0.90; p<0.05) and IIa (EDL, r=-0.52, p<0.05) muscle fibers. These findings indicate that changes in IMCL content but not UCP3 content are implicated in short-term effects of cafeteria-style diet and exercise training on muscular insulin sensitivity in rats.

show abstract

Why Do Low-Fat High-Carbohydrate Diets Accentuate Postprandial Lipemia in Patients With NIDDM?

Cited by 111 publications

References 0 publications

A prospective study of dietary carbohydrate quantity and quality in relation to risk of ovulatory infertility

A prospective study of dietary carbohydrate quantity and quality in relation to risk of ovulatory infertility

Acute Hyperinsulinism Modulates Plasma Apolipoprotein B-48 Triglyceride--Rich Lipoproteins in Healthy Subjects During the Postprandial Period

Hyperglycemic diet and training alter insulin sensitivity, intramyocellular lipid content but not UCP3 protein expression in rat skeletal muscles

Contact Info

Product

Resources

About