Why Do Levels Of Anti-inflammatory Cytokines Increase During Memory Acquisition?

Levin, S. G.; Першина, Е. В.; Bugaev-Makarovskiy, Nickolay A.; Chernomorets, Irina Yu.; Konakov, M. V.; Архипов, В. И.

doi:10.1016/j.neuroscience.2021.08.007

Cited by 11 publications

(4 citation statements)

References 104 publications

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“…Furthermore, anti-inflammatory cytokines such as interleukin-4 (IL-4), interleukin-10 (IL-10) and transforming growth factor beta-1 (TGF- β1), act by suppressing the production and activities of pro-inflammatory cytokines alongside their signaling pathways [ 55 ]. Moreover, studies have shown that anti-inflammatory cytokines have capacity to directly inhibit the peripheral nociceptors sensitization and pain signals transmission [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Tannic acid inhibits pain mediators, inflammation and oxidative stress in mice exposed to glyphosate-based herbicide

Abolarin,

Owoyele

2024

Environ Anal Health Toxicol

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Chronic exposure to glyphosate-based herbicide (Gly) has been associated with neurological disorders. Tannic acid (TA) is an antioxidant with attenuating action against neuroinflammation-associated conditions. This study evaluated the effect of Gly on pain perception alongside antinociceptive and anti-inflammatory actions of TA in Gly-exposed mice. Male Swiss mice were randomly divided into six groups (n=8): control (distilled water 0.2 ml/kg), Gly (Gly 500 mg/kg), Pre-TA + Gly (TA 50 mg/kg pre-treatment, afterwards Gly-administered), TA + Gly (TA 50 mg/kg and Gly co-administered), Pre-AA + Gly (ascorbic acid (AA) 10 mg/kg pre-treatment, afterwards Gly-administered), and AA + Gly (AA 10 mg/kg and Gly co-administered). Mechanical, thermal, and chemical pain were evaluated six weeks post vehicle/drugs administrations orally, followed by brain biochemical measurements. TA treatment alleviated Gly-induced hyperalgesia in similar version to the values of control and AA groups by increasing significantly (p < 0.05) nociceptive thresholds. Moreover, TA-treatment significantly decreased malondialdehyde (MDA) and pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) levels, significantly increased anti-inflammatory cytokines (IL-10, IL-4, and TGF-1β) levels, and antioxidant enzymes, catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) activities compared to Gly-treated mice (p < 0.05). Conclusively, TA treatment exerted antinociceptive and anti-inflammatory actions, possibly through its antioxidant and anti-inflammatory actions in Gly-exposed mice. Notably, TA pre-treatment showed a better response than TA and Gly co-administration. We propose the potential neuroprotective and ameliorative functions of TA in Gly-induced hyperalgesia. This merits further clinical research into protective roles of TA against pesticide-related conditions.

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Section: Discussionmentioning

confidence: 99%

Tannic acid inhibits pain mediators, inflammation and oxidative stress in mice exposed to glyphosate-based herbicide

Abolarin,

Owoyele

2024

Environ Anal Health Toxicol

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“…It was observed that during memory acquisition these anti-inflammatory cytokines optimize information flow. 9 Cytokines are responsible for the onset and progression of different kinds of malignancies. One such example is represented by oral cancer, a medical condition that is accompanied by the increase of IL-8 levels, a proinflammatory cytokine secreted by leukocytes under the action of external factors, including stress.…”

Section: Type Of Cytokinementioning

confidence: 99%

“…In the long term, this state of inflammation can cause damage to the central nervous system, and therefore the body also begins to produce anti‐inflammatory cytokines. It was observed that during memory acquisition these anti‐inflammatory cytokines optimize information flow 9 …”

Section: Introductionmentioning

confidence: 99%

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Unrevealing the connection between real sample analysis and analytical method. The case of cytokines

Irimes

Tertiş

Oprean

et al. 2023

Medicinal Research Reviews

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Cytokines are compounds that belong to a special class of signaling biomolecules that are responsible for several functions in the human body, being involved in cell growth, inflammatory, and neoplastic processes. Thus, they represent valuable biomarkers for diagnosing and drug therapy monitoring certain medical conditions. Because cytokines are secreted in the human body, they can be detected in both conventional samples, such as blood or urine, but also in samples less used in medical practice such as sweat or saliva. As the importance of cytokines was identified, various analytical methods for their determination in biological fluids were reported. The gold standard in cytokine detection is considered the enzyme‐linked immunosorbent assay method and the most recent ones have been considered and compared in this study. It is known that the conventional methods are accompanied by a few disadvantages that new methods of analysis, especially electrochemical sensors, are trying to overcome. Electrochemical sensors proved to be suited for the elaboration of integrated, portable, and wearable sensing devices, which could also facilitate cytokines determination in medical practice.

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Roles of prokineticin 2 in electroconvulsive shock-induced memory impairment via regulation of phenotype polarization in astrocytes

Chen

Min

et al. 2023

Behavioural Brain Research

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Why Do Levels Of Anti-inflammatory Cytokines Increase During Memory Acquisition?

Cited by 11 publications

References 104 publications

Tannic acid inhibits pain mediators, inflammation and oxidative stress in mice exposed to glyphosate-based herbicide

Tannic acid inhibits pain mediators, inflammation and oxidative stress in mice exposed to glyphosate-based herbicide

Unrevealing the connection between real sample analysis and analytical method. The case of cytokines

Roles of prokineticin 2 in electroconvulsive shock-induced memory impairment via regulation of phenotype polarization in astrocytes

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