Why Didn’t You Text Me? Poststudy Trends From the DepoText Trial

Buchanan, Cara; Tomaszewski, Kathy; Chung, Shang En; Upadhya, Krishna K.; Ramsey, Alexandra; Trent, Maria

doi:10.1177/0009922816689674

Cited by 9 publications

(4 citation statements)

References 40 publications

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“…weekly text message reminders. 40 However, the acute need for PID medication reminder support occurs daily over the 14-days after diagnosis rather than family planning injection behaviors occur every 3-months. Future research investigating patient responsiveness to adherence monitoring messages delivered at shorter vs .…”

Section: Discussionmentioning

confidence: 99%

Can Automated Text Messaging Successfully Monitor Antibiotic Adherence for Urban Adolescents and Young Women Managed for Pelvic Inflammatory Disease in the Outpatient Setting

Rice¹,

Perin²,

Huettner³

et al. 2022

Pediatr Neonatal Nurs Open J

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Objective This study evaluates patient responsiveness to an automated text messaging system for pelvic inflammatory disease (PID) self-care support, and measures the reliability of text-reported adherence. Design Patients aged 13-25-years with mild to moderate PID were recruited from urban, academic outpatient settings. Enrolled patients received antibiotics and were randomized into a standard of care or intervention group. During a 14-day treatment period, participants in the intervention arm received a community-based nursing visit and daily text message medication reminders with evening prompts to report the number of doses taken. Result Of the 97 participants randomized into the intervention arm, 91 (94%) were eligible for analysis. Most were African American and low income, with a mean age of 18.3 (SD=2.2) years. Participants responded to ~53% (SD=34%) of all dosage inquiry messages. Responsiveness attenuated at approximately 2.2% per day over the treatment period. Ninety-three percent (n=85) of the analyzed intervention arm returned for the two-week follow-up. Despite overall adherence and general responsiveness, text-reported and self-reported medication adherence were not well correlated (r=0.37, p<0.001). Conclusion Our findings show that text messaging is a feasible strategy for reaching urban adolescents being managed for complicated sexually transmitted infections in outpatient settings. However, patient responsiveness to self-care text messages do vary, limiting the adherence monitoring capacity of this technology. Given the number of unanswered text messages and incomplete text-reported adherence data, additional measures to assess adolescents’ adherence to PID medications are needed in clinical trials.

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Section: Discussionmentioning

confidence: 99%

Can Automated Text Messaging Successfully Monitor Antibiotic Adherence for Urban Adolescents and Young Women Managed for Pelvic Inflammatory Disease in the Outpatient Setting

Rice¹,

Perin²,

Huettner³

et al. 2022

Pediatr Neonatal Nurs Open J

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“…At least one additional article meeting the inclusion criteria for this systematic review has been published since the systematic search of the literature. This article 37 describes longer-term, post-trial data among a subset of adolescents from a study already included in this systematic review in which text reminders for an upcoming visit had no effect on timely DMPA injections. 22 In the article, 37 among 87 of the original 100 enrolled adolescents who completed three maintenance DMPA injection cycles, intervention participants had 3.65 increased odds of continuing to use DMPA or a contraceptive implant at the 20-month follow-up compared with control group participants (95% CI=1.26, 10.08).…”

Section: Discussionmentioning

confidence: 99%

“…This article 37 describes longer-term, post-trial data among a subset of adolescents from a study already included in this systematic review in which text reminders for an upcoming visit had no effect on timely DMPA injections. 22 In the article, 37 among 87 of the original 100 enrolled adolescents who completed three maintenance DMPA injection cycles, intervention participants had 3.65 increased odds of continuing to use DMPA or a contraceptive implant at the 20-month follow-up compared with control group participants (95% CI=1.26, 10.08). These findings are difficult to interpret given that youth who have already completed three maintenance DMPA injection cycles may be more motivated to continue using the method compared with youth who discontinued the method before the third maintenance injection.…”

Section: Discussionmentioning

confidence: 99%

Family Planning Reminder Systems: An Updated Systematic Review

Zapata

Pazol

Rollison

et al. 2018

American Journal of Preventive Medicine

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Context: The objective of this systematic review was to update a prior review and summarize the evidence on the impact of family planning reminder systems (e.g., daily text messages reminding oral contraception users to take a pill). Evidence acquisition: Multiple databases, including PubMed, were searched during 2016–2017 for articles published from March 1, 2011, to November 30, 2016, describing studies of reminder systems. Evidence synthesis: The search strategy identified 24,953 articles, of which two studies met the inclusion criteria. In total with the initial review, four studies (including two RCTs) examined reminder systems among oral contraception users, with two of three that examined correct use finding a statistically significant positive impact, and one RCT finding a positive impact on knowledge and continuation. Of three studies (including two RCTs) that examined reminder systems among depot medroxyprogesterone acetate users, one of three that examined correct use found a statistically significant positive impact on timely injections at 3 months, and one study found no effect on continued use at 12 months. Conclusions: Although this review found mixed support for the effectiveness of reminder systems on family planning behaviors, the highest quality evidence yielded null findings related to correct use of oral contraception and timely depot medroxyprogesterone acetate injections beyond 3 months, and found positive findings related to oral contraception continuation and knowledge. Future studies would be strengthened by objectively measuring outcomes and examining additional contraceptive methods and outcomes at least 12 months post-intervention. Theme information: This article is part of a theme issue entitled Updating the Systematic Reviews Used to Develop the U.S. Recommendations for Providing Quality Family Planning Services, which is sponsored by the Office of Population Affairs, U.S. Department of Health and Human Services.

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“…75 Evidence suggest rates of continuation can be improved through self versus provider administration (73% versus 45%; incidence rate ratio of 0.40 (95% CI 0.31–0.51; p < 0.0001), improving local community access, adherence counselling and text reminders. 76–78 The recently published ECHO study of the impact of long-acting contraceptives and HIV acquisitions, highlights the very real need for closer integration of reproductive health and HIV services, both for prevention and treatment. 79 Implementation studies focusing on reducing subsequent discontinuation of LA- ART as treatment for HIV-1 should run in parallel with their introduction outside of clinical trials.…”

Section: La Injectable Formulations For the Treatment Of Hiv-1mentioning

confidence: 99%

Antiretroviral adherence for adolescents growing up with HIV: understanding real life, drug delivery and forgiveness

Foster

Ayers

Fidler

2020

Therapeutic Advances in Infection

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Poorer adherence to medication is normal in adolescence and is one of a range of risk-taking behaviours common during a developmental stage that encompasses enormous cognitive, physical, sexual, social and emotional change. For adolescents living with human immunodeficiency virus (HIV) infection, poor adherence to antiretroviral therapy (ART) confers two significant challenges: poor health, but also the specific additional burden of onward transmission to partners. Late adolescence (15–19 years) is the only age group where HIV-associated mortality is rising, driven by poor adherence to ART and lack of access to second-line therapy, particularly amongst surviving perinatally infected young people. A previous lack of well-powered randomised multimodal behavioural ART adherence interventions specifically targeting adolescents is now being addressed and ongoing studies registered to ClinicalTrials.gov are described in the context of previous data. Accepting that despite enhanced support, some adolescents will continue to struggle with adherence, we must address how best to use existing ART agents to reduce mortality and allow adolescents the time to mature into adult life. Single-tablet regimens with a high genetic barrier to resistance based on integrase inhibitors and boosted protease inhibitors exist, but global access, in resource limited settings of young people living with HIV reside, is limited. Pragmatically, such regimens tolerate the intermittent adherence so characteristic of adolescence, preserving immune function, without the rapid evolution of resistance. The potential role of long-acting injectable ART, specifically cabotegravir and rilpivirine, is discussed and future strategies including ultra-long-acting drug-delivery systems and broadly neutralising monoclonal antibodies explored.

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Why Didn’t You Text Me? Poststudy Trends From the DepoText Trial

Abstract: Participation in the DepoText trial was associated with continued use of DMPA or a more effective contraceptive method almost 20 months after the intervention exposure ended.

Cited by 9 publications

References 40 publications

Can Automated Text Messaging Successfully Monitor Antibiotic Adherence for Urban Adolescents and Young Women Managed for Pelvic Inflammatory Disease in the Outpatient Setting

Can Automated Text Messaging Successfully Monitor Antibiotic Adherence for Urban Adolescents and Young Women Managed for Pelvic Inflammatory Disease in the Outpatient Setting

Family Planning Reminder Systems: An Updated Systematic Review

Antiretroviral adherence for adolescents growing up with HIV: understanding real life, drug delivery and forgiveness

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