Why “Biomonitoring”?

Moshammer, Hanns

doi:10.2478/bimo-2014-0005

Cited by 3 publications

(3 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chromatographic separation of KHPs, formed by oxidation of large hydrocarbons, and detection by UV absorption or mass spectrometry has been attempted in the past [20][21][22][23][24][25][26][27][28], but suffered from technical limitations. Nowadays, with more powerful analytical techniques such as synchrotron-based mass spectrometry [29,31,32], ultra-high pressure liquid chromatography (UHPLC), and high-resolution mass spectrometry (Orbitrap®), one can expect improving the characterization of cool flame products [33].…”

Section: Introductionmentioning

confidence: 99%

Experimental characterization of n-heptane low-temperature oxidation products including keto-hydroperoxides and highly oxygenated organic molecules (HOMs)

Belhadj

Benoit

Dagaut

et al. 2021

Combustion and Flame

View full text Add to dashboard Cite

The oxidation of n-heptane was performed in a jet-stirred reactor (JSR) at 10 atm, an equivalence ratio of 0.5, and an initial fuel concentration of 1000 ppm at a residence time of 1 s in the temperature range 580-790 K (from coolflame, negative temperature coefficient NTC, to intermediate temperature oxidation regime), and with 5000 ppm of fuel at 647 K and a residence time of 1.5 s. Low-temperature products formed in JSR were characterized using high-resolution mass spectrometry analyses (HRMS). Atmospheric pressure chemical ionizations (APCI) was used in positive and negative modes for MS analyses. Both flow injection analyses (FIA) or ultra-high-pressure liquid chromatography-Orbitrap® coupling were used to characterize hydroperoxides (C 7 H 16 O 2 ), keto-hydroperoxides (C 7 H 14 O 3 ), cyclic ethers (C 7 H 14 O), carboxylic acids (C 2 H 4 O 2 , C 3 H 6 O 2 , C 4 H 8 O 2 ), ketones (C 3-5 H 6-10 O), diones (C 7 H 12 O 2 ), and highly oxygenated molecules (C 7 H 14 O 5 , C 7 H 14 O 7 , C 7 H 14 O 9 , C 7 H 14 O 11 ) resulting from the addition of up to six O 2 molecules on fuel radicals. H/D exchange with D 2 O was used to confirm the presence of -OH or -OOH groups in the products. Several available kinetic reaction mechanisms were tested against the present measurements of keto-hydroperoxides showing significant discrepancies.

show abstract

Section: Introductionmentioning

confidence: 99%

Experimental characterization of n-heptane low-temperature oxidation products including keto-hydroperoxides and highly oxygenated organic molecules (HOMs)

Belhadj

Benoit

Dagaut

et al. 2021

Combustion and Flame

View full text Add to dashboard Cite

show abstract

“…Both DiNP and DiNCH are known to have been used in polyvinyl chloride (PVC) materials like food packaging, with DiNCH commonly used as a replacement for DiNP. 44,45 The declining concentrations of ∑DiNP and ∑DiNCH among these women may thus relate to diet changes during pregnancy. Unfortunately, we had limited information about diet in this cohort to examine potential changes.…”

Section: ■ Discussionmentioning

confidence: 99%

Variability and Longitudinal Trajectories of Phthalate and Replacement Biomarkers across Pregnancy in the Human Placenta and Phthalates Study

Rosen,

Stevens,

McNell

et al. 2023

Environ. Sci. Technol.

View full text Add to dashboard Cite

“…Di(2-ethylhexyl) phthalate (DEHP) is widely used as a plasticizer in polyvinyl chloride products including wall coverings, tablecloths, dolls, toys, shoes, packaging film, medical tubing, and blood storage bags [10]. Diisononyl phthalate (DiNP) has replaced DEHP in some plastics and now is widely used in toys, flooring, gloves, drinking straws, and in sealants used in food packaging [11]. Humans are exposed to these compounds on a daily basis, mainly by oral ingestion [12], and phthalates have been shown to adversely affect reproductive outcomes in several studies [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

The effects of short-term and long-term phthalate exposures on ovarian follicle growth dynamics and hormone levels in female mice

Santacruz-Márquez,

Safar,

Laws

et al. 2023

Biology of Reproduction

View full text Add to dashboard Cite

Di(2-ethylhexyl) phthalate (DEHP) and diisononyl phthalate (DiNP) are widely used as plasticizers in polyvinyl chloride products. Short-term exposures to DEHP or DiNP affect hormone levels, ovarian follicle populations, and ovarian gene expression. However, limited data exist regarding the effects of long-term exposure to phthalates on reproductive functions. Thus, this study tested hypothesis that short-term (1 month) and long-term (6 months) exposure to DEHP or DiNP disrupts follicle dynamics, ovarian and pituitary gene expression, and hormone levels in female mice. Adult CD-1 female mice were exposed to vehicle (corn oil), DEHP, or DiNP (0.15 ppm, 1.5 ppm, or 1500 ppm) via the chow for 1 or 6 months. Exposure to DEHP (0.15 ppm) and DiNP (1.5 ppm) for 1 month decreased serum follicle-stimulating hormone (FSH) levels compared to control. Long-term exposure to DEHP and DiNP (1500) ppm increased the percentage of primordial follicles and decreased the percentages of preantral and antral follicles compared to control. Both phthalates increased FSH levels (DEHP at 1500 ppm; DiNP at 1.5 ppm) and decreased LH levels (DEHP at 0.15 and 1.5 ppm; DiNP at 1.5 ppm and 1500 ppm) compared to control. Further, both phthalates altered the expression of pituitary gonadotropin subunit genes (Cga, Fshb, and Lhb) and a transcription factor (Nr5a1) that regulates FSH and LH synthesis. These data indicate that long-term exposure to DEHP and DiNP alters follicle growth dynamics in the ovary and the expression of gonadotropin subunit genes in the pituitary and consequently LH and FSH synthesis.

show abstract

Why “Biomonitoring”?

Cited by 3 publications

References 38 publications

Experimental characterization of n-heptane low-temperature oxidation products including keto-hydroperoxides and highly oxygenated organic molecules (HOMs)

Experimental characterization of n-heptane low-temperature oxidation products including keto-hydroperoxides and highly oxygenated organic molecules (HOMs)

Variability and Longitudinal Trajectories of Phthalate and Replacement Biomarkers across Pregnancy in the Human Placenta and Phthalates Study

The effects of short-term and long-term phthalate exposures on ovarian follicle growth dynamics and hormone levels in female mice

Contact Info

Product

Resources

About