Why Are Women with Obesity More Likely to Develop Breast Cancer

Chen, Sheng I.; Hsieh, Chia Chien

doi:10.2217/fon-2018-0125

Cited by 9 publications

(11 citation statements)

References 27 publications

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“…Accumulating research and epidemiological studies concluded that obesity increases the risk of breast cancer and therapeutic challenges, while reducing overall prognosis [5,7,16]. In this study, aspirin's effects on the inflammation and metabolomics of adipocytes and the growth of breast cancer cells were investigated.…”

Section: Discussionmentioning

confidence: 99%

“…Corroborating evidence exists showing that obesity is associated with cancer development and progression due to chronic inflammation, hormonal imbalances, and metabolic abnormalities [4]. Obesity is recognized as a significant risk for breast cancer development, with obese breast cancer patients shown to have overall lower survival rates and higher risk of recurrence regardless of whether therapeutic interventions are sought [5,6]. Carcinogenesis progression involves the participation of endothelial cells, stromal fibroblasts, tumor cells, and infiltrating immune cells.…”

Section: Introductionmentioning

confidence: 99%

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Aspirin Modifies Inflammatory Mediators and Metabolomic Profiles and Contributes to the Suppression of Obesity-Associated Breast Cancer Cell Growth

Hsieh

Chiu

Wang

et al. 2020

IJMS

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Breast cancer is the most common cancer among women. Adiposity generally accompanies immune cell infiltration and cytokine secretion, which is ideal for tumor development. Aspirin is a chemopreventive agent against several types of cancer. The aim of this study was to investigate whether aspirin inhibits the growth of 4T1 breast cancer cells by inhibiting the inflammatory response and regulating the metabolomic profile of 3T3-L1 adipocytes. 3T3-L1 adipocyte-conditioned medium (Ad-CM) was used to mimic the obese adipose tissue microenvironment in 4T1 cells. The results revealed that aspirin inhibited macrophage chemoattractant protein (MCP-1), interleukin (IL-6), IL-1β, and plasminogen activator inhibitor (PAI-1) production in 3T3-L1 adipocytes stimulated by tumor necrosis factor-alpha (TNF-α) and lipopolysaccharide (LPS). In the obesity-associated model, Ad-CM significantly promoted 4T1 cell growth and migration, which were attenuated after aspirin treatment. The results of metabolic analyses using Ad-CM showed that amino acid metabolites and oxidative stress were increased in mature 3T3-L1 adipocytes compared to those in fibroblasts. Aspirin treatment modified metabolites involved in suppressing lipogenesis, oxidative stress, and neoplastic formation. In the relative fatty acid quantitation analysis of Ad-CM, aspirin diminished fatty acid contents of C16:1, C18:1, C18:2, C20:4, and C24:1. This study is the first to show that aspirin modifies the metabolomics and fatty acid composition of 3T3-L1 adipocytes and inhibits obesity-associated inflammation that contributes to obesity-related breast cancer cell growth and migration.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aspirin Modifies Inflammatory Mediators and Metabolomic Profiles and Contributes to the Suppression of Obesity-Associated Breast Cancer Cell Growth

Hsieh

Chiu

Wang

et al. 2020

IJMS

Self Cite

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“…Increased incidence of breast cancer in obese women has been noted in several epidemiological studies [32]. The type 1 cytokines and leptin have shown to induce aromatase expression, encoded by the CYP19 gene, in un- Fig.…”

Section: Adiposity and Risk Of Cancer -Molecular Cross-talkmentioning

confidence: 95%

“…differentiated adipocytes stimulating estrogen synthesis, which manifests as increased expression in estrogen receptors' target genes. Consequently, this increased biosynthesis of estrogen has been linked to the incidence of estrogen receptor-positive breast cancer in obese women [32,33]. An increased efflux of fatty acids has been observed in obese individuals.…”

Section: Adiposity and Risk Of Cancer -Molecular Cross-talkmentioning

confidence: 99%

Biological Support to Obesity Paradox in Renal Cell Carcinoma: A Review

2020

Urol Int

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Obesity is a proven risk factor and a debated prognostic factor in renal cell carcinoma (RCC). Termed as an "obesity paradox," the topic has churned controversies, with a few arguing of no true biological association. Suggesting otherwise, a few studies revealed adiposity-induced altered molecular and transcriptomic signatures, at both the systemic and local (tumor and peritumoral adipose tissue) levels, in RCC patients, favoring the paradox. Summarizing such studies suggests of a considerable biological support to adiposity as a promising prognostic factor in RCC patients, although much needs to be clarified before adopting it as a valuable addition to the existing prognostic model.

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“…O crescimento desordenado das células com capacidade para diferenciação e invasão de tecidos e órgãos, vizinhos ou distantes, é a definição científica de câncer. Constituída como uma enfermidade multicausal crônica, o câncer de mama é também uma doença genética e de maior incidência na população feminina (Chen & Hsieh, 2018).…”

Section: Câncer De Mamaunclassified

Obesidade e Câncer de mama: Algumas evidências científicas e vias de interação

Nogueira

Araújo

Caldas

et al. 2020

RSD

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1 Obesidade e Câncer de mama: Algumas evidências científicas e vias de interação Obesity and Breast cancer: Some scientific evidence and ways of interaction Obesidad y Cáncer de mama: Algunas pruebas científicas y formas de interacción Resumo O presente estudo objetivou investigar na literatura o conhecimento atual sobre a relação entre obesidade e neoplasia mamária. Trata-se de uma revisão integrativa realizada por meio da Research, Society and Development, v. 9, n. 4, e84942675, 2020 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v9i4.2675 2 busca de artigos originais que relacionavam obesidade e câncer de mama, publicados nos últimos cinco anos e indexados às bases de dados PubMed, Scopus e Web of Science. Do total recuperado, foram incluídos 5 artigos para leitura integral por corresponderem aos critérios de elegibilidade. Observou-se que 40% (n=2) dos estudos apontaram para a influência dos aspectos metabólicos característicos do obeso, sobre a etiologia do câncer de mama, como também, 20% (n=1) dos estudos demonstrou que níveis alterados de adiponectina e leptina estão associados a patogênese da neoplasia em questão. Apesar disso, uma citação não observou efeito da obesidade sobre o quadro de pacientes quimioterápicos.Concluiu-se que a literatura aponta para a relação entre obesidade e câncer de mama, embora os estudos sejam considerados ainda pouco elucidativos. Palavras-chave: Adiposidade; Neoplasia Mamária; Estado Menopausal. AbstractThe present study aimed to investigate in the literature the current knowledge about the relationship between obesity and breast cancer. This is an integrative review carried out by searching for original articles that related obesity and breast cancer, published in the last five years and indexed to the PubMed, Scopus and Web of Science databases. Of the total recovered, 5 articles were included for full reading because they correspond to the eligibility criteria. It was observed that 40% (n=2) of the studies pointed to the influence of the metabolic aspects characteristic of the obese, on the etiology of breast cancer, as well as, 20% (n=1) of the studies demonstrated that altered levels of adiponectin and leptin are associated with the pathogenesis of the neoplasia in question. Despite this, a quote did not observe the effect of obesity on the status of chemotherapy patients. It was concluded that the literature points to the relationship between obesity and breast cancer, although the studies are still considered to be poorly understood. ResumenEl presente estudio tuvo como objetivo investigar en la literatura el conocimiento actual sobre la relación entre la obesidad y el cáncer de mama. Esta es una revisión integradora realizada mediante la búsqueda de artículos originales relacionados con la obesidad y el cáncer de seno, publicados en los últimos cinco años e indexados a las bases de datos PubMed, Scopus y Web

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Why Are Women with Obesity More Likely to Develop Breast Cancer

Cited by 9 publications

References 27 publications

Aspirin Modifies Inflammatory Mediators and Metabolomic Profiles and Contributes to the Suppression of Obesity-Associated Breast Cancer Cell Growth

Aspirin Modifies Inflammatory Mediators and Metabolomic Profiles and Contributes to the Suppression of Obesity-Associated Breast Cancer Cell Growth

Biological Support to Obesity Paradox in Renal Cell Carcinoma: A Review

Obesidade e Câncer de mama: Algumas evidências científicas e vias de interação

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