Why are women predisposed to autoimmune rheumatic diseases?

Oliver, Jason D.; Silman, Alan J.

doi:10.1186/ar2825

Cited by 164 publications

(153 citation statements)

References 78 publications

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“…Our study showed that women with SCD were 10 times more likely to have RA than men with SCD which is significantly greater than the reported gender differences in the general population where women were 3 times more likely to develop RA compared to men [15]. SCD could potentially have an increased risk of developing CTD similar to that speculated for patients with beta-thalassemia trait and its association with higher rates of RA [1,16].…”

Section: Prevalence Of Positive Serology and Connective Tissue Diseasesupporting

confidence: 47%

Increased Prevalence of Autoimmunity and Connective Tissue Diseases in Sickle Cell Disease

Igbineweka¹,

Darbari²,

Drašar³

et al. 2016

J Gen Pract

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Connective tissue disease (CTD) and sickle cell disease (SCD) are diverse group of disorders; however, both of these diseases are characterized by underlying chronic inflammation. CTD is perceived to have a higher incidence and to affect the disease severity in SCD. Objectives:We seek to describe prevalence of autoimmunity and CTD and itsimpact on SCD disease severity as this is not well described in the literature. Methods:We retrospectively reviewed the medical records of 722 patients with SCD, seen over an 11 year period followed at a tertiary care hospital in London, UK. During the last 2 years of the study, number of hospitalizations and length of hospital stay were compared in patients with SCD with and without CTD. Results:In the study cohort, hemoglobin SS was the most common genotype (n = 451; 62%) and 411 (57%) were female. Twenty-three patients (3.1% had documented evidence of CTD, with rheumatoid arthritis (n = 14; 2%) and systemic lupus erythematosus (n = 2; 0.3%) being the most common. Antinuclear antibody was present in 108 (15%) of the patients and anti-smooth muscle antibody was present in 60 (8%). The mean number of hospitalizations (1.9 ± 2.7 vs. 1.5 ± 2.7) and mean length of hospital stay (6 days ± 4.1 vs. 7 days ± 11.4) were not different between those with or without autoimmunity and/or CTD. Avascular necrosis was the most common non-CTD musculoskeletal complication, affecting 72 (10%) patients. Conclusion:Our study suggests that positive autoimmune serology and CTD were more common in SCD compared to non-SCD population of similar ethnic background; however, presence of CTD does not appear to affect the SCD severity. The high frequency of CTD and overlapping of clinical symptoms suggest a need for diagnostic vigilance in diagnosing CTD in patients with SCD.

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Section: Prevalence Of Positive Serology and Connective Tissue Diseasesupporting

confidence: 47%

Increased Prevalence of Autoimmunity and Connective Tissue Diseases in Sickle Cell Disease

Igbineweka¹,

Darbari²,

Drašar³

et al. 2016

J Gen Pract

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“…However, hormonal--sexual complications (such as menstrual disorders and early menopause) were not evaluated in the present study. Perhaps the relationship between early adverse effects and the patients' sex is associated with the higher prevalence of certain diseases among women, or with more severe disease than among men, rather than being directly related to the use of CP [27]. This issue surely requires further study.…”

Section: Discussionmentioning

confidence: 99%

The Safety of Intravenous Cyclophosphamide in the Treatment of Rheumatic Diseases

Woytala¹,

Morgiel²,

Łuczak³

et al. 2016

Adv Clin Exp Med

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“…[15][16][17] The reason for the female predominance in autoimmune diseases is not completely understood; nevertheless, the finding of a similar pattern of female dominance in ANA production suggests that hormonal or other factors in females play a role in this process. 18,19 Several authors reported prevalence of ANA in RA has been variable in several published series ranging from 10% to 70%. 20 The variability in prevalence is probably due to multiple factors including patient selection and technical factors such as type of substrate used in the test, characteristics of the fluorescent reagents, etc.…”

Section: Discussionmentioning

confidence: 99%

Association of ANA seropositivity with RF, CRP, Brucellosis test in patients with SLE, a compression between immunofluorescence technique and latex agglutination

Saeed

Al-Ameri

2017

IMJ

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Objectives The present study aims to inspect the connection between patients with SLE and RF, CRP, Brucellosis and compression between immunofluorescence technique and latex agglutination method to detect ANA. Methods A total of 90 serum sample collected from patients with symptoms and signs of SLE those send to the immunity lab in Al-Hussein hospital. The immunofloriscent ANA test, SLE latex agglutination test, RF, CRP and Rose Bengal tests were done to all these samples. Results The results show that there was significant difference between males (16%) and females (84%) patients with sign and symptom of SLE, while there was no significant difference in CRP, RF, in patients with SLE positive (50%,17%) and SLE negative patients (48.5%,17%), continuously Rose Bengal test is higher in SLE negative patients than in SLE positive patients (15.2%, 8.3%). Finally, there is significant difference in diagnosis of SLE disease between IF technique and latex agglutination test (41.6%, 100%). Conclusions Latex agglutination test for ANA detection is reliable, specific but less sensitive test when compared to SLE IF test. There are significance differences in Rose Bengal test in SLE negative and in SLE positive patient's, while there are non-significance difference in CRP, RF in SLE positive samples and in SLE negative samples.

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Why are women predisposed to autoimmune rheumatic diseases?

Cited by 164 publications

References 78 publications

Increased Prevalence of Autoimmunity and Connective Tissue Diseases in Sickle Cell Disease

Increased Prevalence of Autoimmunity and Connective Tissue Diseases in Sickle Cell Disease

The Safety of Intravenous Cyclophosphamide in the Treatment of Rheumatic Diseases

Association of ANA seropositivity with RF, CRP, Brucellosis test in patients with SLE, a compression between immunofluorescence technique and latex agglutination

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