Why are women more likely than men to develop heart failure with preserved ejection fraction?

Scantlebury, Dawn C.; Borlaug, Barry A.

doi:10.1097/hco.0b013e32834b7faf

Cited by 197 publications

(165 citation statements)

References 70 publications

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“…92, 93 In addition, the ability to tolerate volume loading without excessive increase in LVFP decreases in older women. 94 Given these observations, together with the foregoing findings, therapies targeting age-related LV diastolic stiffening would appear to hold promise to help improve exercise capacity and outcomes in HFpEF.…”

Section: Exercise Reserve Hfpef and Normal Agingmentioning

confidence: 99%

Mechanisms of Exercise Intolerance in Heart Failure With Preserved Ejection Fraction

Borlaug

2014

Circ J

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Approximately half of patients with heart failure (HF) have a preserved ejection fraction (HFpEF), and with the changing age and comorbidity characteristics in the adult population, this number is growing rapidly. The defining symptom of HFpEF is exercise intolerance, but the specific mechanisms causing this common symptom remain debated and inadequately understood. Although diastolic dysfunction was previously considered to be the sole contributor to exercise limitation, recent studies have identified the importance of ventricular systolic, chronotropic, vascular, endothelial and peripheral factors that all contribute in a complex and highly integrated fashion to produce the signs and symptoms of HF. This review will explore the mechanisms underlying objective and subjective exercise intolerance in patients with HFpEF. (Circ J 2014; 78: 20 -32)

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Section: Exercise Reserve Hfpef and Normal Agingmentioning

confidence: 99%

Mechanisms of Exercise Intolerance in Heart Failure With Preserved Ejection Fraction

Borlaug

2014

Circ J

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“…Levy et al [18] observed that risk for HF in hypertensive when compared to normotensive, was twice as high in men and three times higher in women [10,12]. Framingham Heart Study also reported that diabetic women, even at ages 35 to 64, were twice as likely to develop HF as diabetic men of the same age.…”

Section: Risk Factors and Aetiologymentioning

confidence: 87%

“…The Euro Heart Survey of Stable Angina observed that inadequate and casual management of IHD in women in the past may be the cause for a higher incidence and early prevalence of HF in elderly women after MI [18]. Valvular heart disease particularly obstructive pathology (aortic stenosis/mitral stenosis) is another important cause of HF in women, than in men.…”

Section: Risk Factors and Aetiologymentioning

confidence: 99%

Heart Failure in Women

Kadiyala

2017

Ind J Car Dis Wom

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“…They have more pronounced concentric ventricular remodelling and less dilation in response to hypertension. 15 Therefore they are more likely to develop cardiac failure. 15 Whether this translates to greater perioperative risk among women needs to be studied.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and distribution of hypertension among the patients presenting for surgery under anaesthesia in a tertiary care hospital in South India

Paulose

Raajesh

Puthupattan

2016

Int J Community Med Public Health

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INTRODUCTIONDuring perioperative period there are important events which cause escalation in blood pressure like tracheal intubation, surgical incision, emergence from anaesthesia and post-operative pain.1 This rise in blood pressure is exaggerated in patients who have preoperative untreated hypertension.2 In a study on the contribution of hypertension to death due to cardiovascular complications within 30 days of anaesthesia and surgery, preoperative hypertension was found to be four times likely than matched controls.3 So detecting and treating these patients is of paramount importance due to the high degree of morbidity and mortality these patients carry. ABSTRACTBackground: Untreated perioperative hypertension can have deleterious effect on patient outcome following surgery. Therefore, many anaesthesiologists prefer to have elective surgeries deferred till the blood pressure is under control. This results in delay and inconvenience to the patient. We designed this study to determine the magnitude of this problem. Methods:The pre-anaesthesia records of 400 consecutive patients who underwent surgery under general or regional anaesthesia were reviewed. They were grouped into known hypertensive, newly detected hypertensive in the present visit or normal. Results: 6.4% of patients in the above 40 year age group, who are the population at risk for developing hypertension, had newly detected hypertension. Higher percentage of women than men in this age group were hypertensive though not statistically significant. The prevalence of hypertension (the sum of known hypertensive and newly detected hypertensive patients) was 9.25% in our study. In the above 40 age group this figure was 18.8%. Significantly higher numbers of women were hypertensive as compared to men (23.4% vs 11.6%) in this age group. Conclusions: Our findings show that the number of newly detected hypertensive patients in the surgical population is low and hence this does not pose a significant problem. The percentage of newly detected hypertension and the prevalence of hypertension in the present study are lower than that reported in the general population from other parts of India. This warrants further studies in our geographical area to determine if similar trend exists in the general population too.

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Why are women more likely than men to develop heart failure with preserved ejection fraction?

Cited by 197 publications

References 70 publications

Mechanisms of Exercise Intolerance in Heart Failure With Preserved Ejection Fraction

Mechanisms of Exercise Intolerance in Heart Failure With Preserved Ejection Fraction

Heart Failure in Women

Prevalence and distribution of hypertension among the patients presenting for surgery under anaesthesia in a tertiary care hospital in South India

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