Why and how we must analyze urinary calculi

Gràcia-Garcia, Sílvia; Millán-Rodríguez, F.; Rousaud-Barón, F.; Montañés-Bermúdez, Rosario; Angerri-Feu, O.; Sánchez-Martín, F.M.; Villavicencio-Mavrich, H.; Oliver-Samper, A.

doi:10.1016/j.acuroe.2011.01.005

Cited by 12 publications

(8 citation statements)

References 11 publications

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“…is classification is used by other laboratories [2][3][4]. Six different morphological types of renal stones are identified with several subtypes (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Improvement of Urinary Stones Analysis Combining Morphological Analysis and Infrared Spectroscopy

Gervasoni

Primiano

Ferraro

et al. 2018

Journal of Chemistry

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Daudon et al. have developed a complex morphoconstitutional classification of renal stone in six different morphological types and several subtypes. According to this classification, a precise correspondence exists between causes of renal stones and subtypes with a great clinical relevance and can be considering a sort of shortcut for the metabolic diagnosis in renal stone patients. Now the diagnosis of causes of renal stones generally requires repeated biochemical investigations on urine and blood samples and usually remains presumptive. We analyzed 150 urinary stones both by stereoscopic microscopy and Fourier transform infrared spectroscopy. e comparison of 150 stones did not reveal any disagreement. We have only 20 partial agreement, and clinicians agreed that the imprecise information obtained with morphological analysis alone would have missed an important clinical finding only in 3 cases. In conclusion, in our opinion, the analysis of urinary stone must combine two different analytical techniques: morphological analysis by stereomicroscope and biochemical analysis with the FT-IR.

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“…is classification is used by other laboratories [2][3][4]. Six different morphological types of renal stones are identified with several subtypes (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Improvement of Urinary Stones Analysis Combining Morphological Analysis and Infrared Spectroscopy

Gervasoni

Primiano

Ferraro

et al. 2018

Journal of Chemistry

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“…With these findings, we observed that stone-forming dogs living within ITMVB have a higher risk of developing SiU because the drinking water of this region contains a higher concentration of Si ( Figure 1 ). In humans, the frequency of SiU is unknown because conventional techniques, such as the metabolic profile of lithiasis performed in humans, do not allow the identification of this mineral [ 30 ] and for the identification of SiO in uroliths, it is necessary to use analysis techniques, such as infrared spectroscopy. The cases of SiU in the dogs studied herein can be a sentinel epidemiological model for the presentation of urolithiasis in humans in Mexico.…”

Section: Discussionmentioning

confidence: 99%

Canine Silica Urolithiasis in Mexico, Associated with the Concentration of Dissolved Silica in Tap Water

Mendoza-López

Del-Angel-Caraza

Aké-Chiñas

et al. 2021

Veterinary Medicine International

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Silica urolithiasis is infrequent in dogs, but in Mexico represents 12.9%. Our hypothesis is the consumption of high amounts of silicates in the diet, especially that dissolved in tap water. The objective of this study was to determine the concentrations of silica in the tap water in different geographical areas and their relationship with cases of silicate urolithiasis in dogs. From 179 cases of silicate urolithiasis, 98.9% were from dogs within a geographic area called the Trans-Mexican Volcanic Belt, which represents a cross shaft to the center of the country. Silica concentrations in tap water ranged between 3 and 76 mg/L, with a range of 27 to 76 mg/L, a mean of 49.9 ± 12 mg/L within the Trans-Mexican Volcanic Belt, and a concentration from 3 to 30 mg/L, with a mean of 16.4 ± 7 mg/L outside this area; these were significantly different ( p < 0.001 ). These findings demonstrate that there is a geographic risk factor for silicate urolithiasis in urolith-forming dogs, related to the consumption of tap water with a high concentration of silica. Further studies are necessary to identify this same pathophysiological association in other species.

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“…L'introduction des nouveaux concepts de chimie douce, des sciences de surface et de la nanochimie couplée à des techniques de physicochimie avancées, au sein même des services hospitaliers est désormais une réalité incontournable. Le succès rencontré pour la lithiase qui est désormais un examen de routine [136][137][138][139] s'affirme de plus en plus comme une réalité pour les pathologies microcristallines rénales. Plus de quatre cents patients ont bénéficié de cette approche et les programmes de recherche en cours où l'on croise notamment la physicochimie à des échelles subcellulaires et les données cliniques des patients greffés devraient sans aucun doute aboutir à des avancées significatives dans l'épidémiologie et la compréhension des processus biochimiques associés aux calcifications pathologiques.…”

Section: Conclusion Et Perspectivesunclassified

Some advances in the field of physico-chemical characterization of pathological microcrystals

Bazin¹,

Daudon²

2015

Annales De Biologie Clinique

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Cette mise au point a pour objet de dépeindre les avancées récentes effectuées pour les pathologies microcristallines grâce à la mise en oeuvre de techniques de physicochimie. Pour le clinicien, cette nouvelle opportunité permet pour certaines pathologies sévères la pose d'un diagnostic précoce. En ce qui concerne les pathologies microcristallines rénales, plus de quatre cents biopsies ont déjà bénéficié d'une telle approche. L'ensemble des données permet une description précise de la physicochimie associée, étape incontournable si l'on désire comprendre en détail les processus biochimiques responsables de leur formation. Parmi ces quatre cents patients, soulignons que pour 7 d'entre eux, la pose d'un diagnostic précoce à partir notamment des mesures réalisées sur le synchrotron Soleil leur a permis d'éviter la dialyse et la greffe.Désormais, nous nous intéressons à des pathologies microcristallines touchant d'autres organes et cette recherche s'effectue sur le plan international en étroite collaboration avec différents services d'anatomopathologie et plusieurs équipes médicales françaises et étrangères. Après avoir esquissé le formalisme de deux techniques, la microscopie électronique à balayage et la microspectroscopie infrarouge à transformée de Fourier qui jouent un rôle-clé dans cette recherche, quelques exemples sont donnés. Pour la spectroscopie infrarouge, l'utilisation du rayonnement synchrotron comme sonde sera abordée.

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Why and how we must analyze urinary calculi

Cited by 12 publications

References 11 publications

Improvement of Urinary Stones Analysis Combining Morphological Analysis and Infrared Spectroscopy

Improvement of Urinary Stones Analysis Combining Morphological Analysis and Infrared Spectroscopy

Canine Silica Urolithiasis in Mexico, Associated with the Concentration of Dissolved Silica in Tap Water

Some advances in the field of physico-chemical characterization of pathological microcrystals

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