Why a Special Issue on Acoustic Liquid Handling?

Molecular Biosensors for Electrochemical Detection of Infectious Pathogens in Liquid Biopsies: Current Trends and Challenges

“…Electrochemical biosensors described to date for bacterial infections [ 28 , 32 , 33 , 34 , 35 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ] comprise a rather limited number of immunosensors using antibodies able to detect the whole bacteria ( Streptococcus pseudopneumoniae , Escherichia coli and Vibrio cholerae ) [ 36 , 37 , 38 ] or specific surface bacterial proteins (PspA peptide) [ 28 ], and a wide variety of nucleic acid sensors targeting specific bacterial genes used along with different nucleic acid and signal amplification strategies [ 32 , 33 , 34 , 35 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ].…”

“…The applicability of the electrokinetic-enhanced biosensing platform was checked through the rapid determination of the antibiotic resistance profiles of Escherichia coli clinical isolates in blood cultures. The same authors developed a multiplexed electrochemical biosensor for bloodstream infection diagnosis by detecting the species-specific sequences of the 16S rRNA of bacteria including Staphylococcus aureus , Escherichia coli , Pseudomonas aeruginosa and Proteus mirabilis in physiological samples without pre-amplification [ 41 ]. In this case, the DNA sensing platform was prepared using a ternary layer composed of thiolated capture probe, hexanedithiol (HDT) and MCH.…”

The evolution of drug discovery: from phenotypes to targets, and back

“…This difficulty is ameliorated by advances in automation and miniaturization, including technologies such as acoustic liquid handling. 126 Furthermore, a variety of approaches employing mathematical modeling, pathway/network analyses, or cell-signatures have been developed to predict potentially useful drug combinations. 127 Target deconvolution strategies may provide additional rationales for testing particular compound combinations.…”

Centrifugal Microfluidic Control Mechanisms for Biosensors

“…E. Acoustic drive: Acoustic droplet ejection is also common in this area. (20) A localized acoustic vibration transmitted on a solid surface is called a surface acoustic wave (SAW). The SAW damps the emission of a longitudinal wave in a liquid under the condition that a liquid exists on the propagation face.…”