Whooping cough due to Bordetella parapertussis: an unresolved problem

Watanabe, Mineo; Nagai, Masaaki

doi:10.1586/14787210.2.3.447

Cited by 58 publications

(56 citation statements)

References 18 publications

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“…Disease due to B. parapertussis infection is often regarded as milder than that due to B. pertussis, although it is clear that many symptoms appear similar. 41 Several tests are used in diagnostic laboratories to confirm B. pertussis infection: direct fluorescent antibody staining of organisms in respiratory tract fluids, culture of the organism and polymerase chain reaction (PCR). Direct antibody staining is thought to be of low sensitivity and is not widely used.…”

Section: B Parapertussismentioning

confidence: 99%

“…41 Furthermore, by several different analyses, it appears that B. pertussis vaccines offer little, if any, protection against B. parapertussis even though this bacterium expresses filamentous hemagglutinin, pertactin and fimbriae. 41 Differences between epitopes (the specific region of a molecule to which antibodies bind) of these factors in the 2 species likely account for this lack of protection, and genome sequence analysis identification of several differences between the B. pertussis and B. parapertussis components supports this argument. 27 At present, both B. pertussis and B. parapertussis appear to occupy the same niche in humans.…”

Section: B Parapertussismentioning

confidence: 99%

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Bordetella pertussis: the intersection of genomics and pathobiology

Preston¹

2005

Canadian Medical Association Journal

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THERE HAS BEEN MUCH RECENT CONCERN over an increasing incidence of pertussis despite high levels of vaccine coverage of infants. Many reports have documented that much of the increased incidence is due to infection in adolescents and adults. This renewal of interest in pertussis comes at a time when the findings of the Bordetella genome project have led to a quantum leap forward in our understanding of the biology, evolution and pathogenesis of the bacterium responsible for the disease. The impact of this basic research on current clinical problems posed by B. pertussis infection is discussed.

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Section: B Parapertussismentioning

confidence: 99%

Section: B Parapertussismentioning

confidence: 99%

Bordetella pertussis: the intersection of genomics and pathobiology

Preston¹

2005

Canadian Medical Association Journal

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“…Some data suggest that an increase in respiratory illness caused by B. parapertussis is occurring (28). B. parapertussis causes a less severe infection than B. pertussis.…”

mentioning

confidence: 99%

Novel Multitarget Real-Time PCR Assay for Rapid Detection of Bordetella Species in Clinical Specimens

et al. 2011

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A novel multitarget real-time PCR (RT-PCR) assay for the rapid identification of Bordetella pertussis, B. parapertussis, and B. holmesii was developed using multicopy insertion sequences (ISs) in combination with the pertussis toxin subunit S1 (ptxS1) singleplex assay. The RT-PCR targets for the multiplex assay include IS481, commonly found in B. pertussis and B. holmesii; IS1001 of B. parapertussis; and the IS1001-like sequence of B. holmesii. Overall, 402 Bordetella species and 66 non-Bordetella species isolates were tested in the multitarget assay. Cross-reactivity was found only with 5 B. bronchiseptica isolates, which were positive with IS1001 of B. parapertussis. The lower limit of detection (LLOD) of the multiplex assay was similar to the LLOD of each target in an individual assay format, which was approximately 1 genomic equivalent per reaction for all targets. A total of 197 human clinical specimens obtained during cough-illness outbreak investigations were used to evaluate the multitarget RT-PCR assay. The multiplex assay results from 87 clinical specimens were compared to the individual RT-PCR assay and culture results. The multitarget assay is useful as a diagnostic tool to confirm B. pertussis infections and to rapidly identify other Bordetella species. In conclusion, the use of this multitarget RT-PCR approach increases specificity, while it decreases the amount of time, reagents, and specimen necessary for RT-PCRs used for accurate diagnosis of pertussis-like illness.

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“…Since the diferential diagnosis would not afect clinical procedures, the vast majority of pertussis studies are not directed to the identiication of B. parapertussis, which probably has led to unreported cases. However, studies aimed at the diferential diagnosis showed that B. parapertussis comprise from 2 to 36% of the cases [94].…”

Section: Pertussis Resurgence: a Multifactorial Problemmentioning

confidence: 99%

Immunization against Pertussis: An Almost Solved Problem or a Headache in Public Health

Dias¹,

Prestes²,

Cunegundes³

et al. 2017

Vaccines

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Whooping cough or pertussis is a serious infectious disease of the human respiratory tract, caused by Gram-negative bacteria Bordetella pertussis and Bordetella parapertussis HU . The current pertussis vaccines may consist of dead cells of B. pertussis (whole cell pertussis vaccines-wPs) or purified antigens from the bacterium (acellular pertussis vaccines-aPs). The aPs are less reactogenic and have been widely used in developed countries for more than two decades, but their high cost of production makes them prohibitive for developing countries, and the accelerated rate of epidemic outbreaks has led to the hypothesis that aPs are less effective than the wP ones. Considering cost-effectiveness, some authors have pointed out questions about the possibility of reintroduction of wP vaccines into the primary doses of pertussis vaccination. The Butantan Institute in São Paulo, Brazil, developed a wP vaccine with low endotoxicity (Plow) obtained by chemical extraction of the lipooligosaccharide (LOS) fraction from the outer membrane of the bacterial cell, showing to be less reactogenic and equally immunogenic and protective as the traditional wP vaccine. The Plow may possibly be introduced into the vaccination schedule for immunization of adolescents and young adults in Brazil, an important epidemiological contribution to reducing the circulation of B. pertussis.

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Whooping cough due to Bordetella parapertussis: an unresolved problem

Cited by 58 publications

References 18 publications

Bordetella pertussis: the intersection of genomics and pathobiology

Bordetella pertussis: the intersection of genomics and pathobiology

Novel Multitarget Real-Time PCR Assay for Rapid Detection of Bordetella Species in Clinical Specimens

Immunization against Pertussis: An Almost Solved Problem or a Headache in Public Health

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