Whole-transcriptome response to wastewater treatment plant and stormwater effluents in the Asian clam, Corbicula fluminea

Bertucci, Anthony; Pierron, Fabien; Gourvès, Pierre-Yves; Klopp, Christophe; Lagarde, Gauthier; Pereto, Clément; Dufour, Vincent; Gonzalez, Patrice; Coynel, Alexandra; Budzinski, Hélène; Baudrimont, Magalie

doi:10.1016/j.ecoenv.2018.08.090

Cited by 23 publications

(12 citation statements)

References 91 publications

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“…One important piece of knowledge to be gained from using transcriptomics is that an integrated mechanistic response to urban stressors is automatically obtained, where pathway analyses can provide a central step in our understanding of how different genes and their expression are interconnected or decoupled (e.g. Watson et al, 2017;Bertucci et al, 2018). These changes could then be followed up with targeted physiological measurements to estimate the actual effect, the physiological robustness, plasticity and its potential effect on fitness and species resilience.…”

Section: Discussionmentioning

confidence: 99%

Urban ecophysiology: beyond costs, stress and biomarkers

Isaksson

2020

Journal of Experimental Biology

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Natural habitats are rapidly declining due to urbanisation, with a concomitant decline in biodiversity in highly urbanised areas. Yet thousands of different species have colonised urban environments. These organisms are exposed to novel urban conditions, which are sometimes beneficial, but most often challenging, such as increased ambient temperature, chemicals, noise and light pollution, dietary alterations and disturbance by humans. Given the fundamental role of physiological responses in coping with such conditions, certain physiological systems such as the redox system, metabolism and hormones are thought to specifically influence organisms’ ability to persist and cope with urbanisation. However, these physiological systems often show mixed responses to urbanisation. Does this mean that some individuals, populations or species are resilient to the urban environmental challenges? Or is something missing from our analyses, leading us to erroneous conclusions regarding the impact of urbanisation? To understand the impact of urbanisation, I argue that a more integrated mechanistic and ecological approach is needed, along with experiments, in order to fully understand the physiological responses; without knowledge of their ecological and evolutionary context, physiological measures alone can be misinterpreted. Furthermore, we need to further investigate the causes of and capacity for individual plasticity in order to understand not only the impact of urbanisation, but also species resilience. I argue that abiotic and biotic urban factors can interact (e.g. pollution with micro- and macronutrients) to either constrain or relax individual physiological responses – and, thereby, plasticity – on a temporal and/or spatial scale, which can lead to erroneous conclusions regarding the impact of urbanisation.

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Section: Discussionmentioning

confidence: 99%

Urban ecophysiology: beyond costs, stress and biomarkers

Isaksson

2020

Journal of Experimental Biology

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“…The concentrations of COD and TSS and ISS during the initial rainwater were higher while the concentrations of TP and TN were relatively low [22]. Therefore, when the surface runoff entered WWTP, the concentrations of COD, TSS, and ISS first reflected the scouring effect of initial rainwater and then reflected the dilution effect of surface runoff [23]. The effects on TN and TP were primarily dilution [24].…”

Section: Discussionmentioning

confidence: 99%

The Shock Effect of Inorganic Suspended Solids in Surface Runoff on Wastewater Treatment Plant Performance

Tan²,

Zhi-xi

et al. 2019

IJERPH

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Previous studies on the water quality of surface runoff often focused on the chemical oxygen demand (COD), nitrogen, phosphorus, and total suspended solid (TSS), but little is known in terms of the inorganic suspended solids (ISS). This research investigated the effects of ISS carried by surface runoff on the treatment efficiency of the pretreatment facilities and the ratio of mixed liquor volatile suspended solid to mixed liquor suspended solid (MLVSS/MLSS) of the activated sludge in a wastewater treatment plant (WWTP) with the anaerobic-anoxic-oxic (AAO) process in Chongqing city, China. The results showed that the surface runoff had a long-lasting impact on the grit removal capacity of the grit chamber, affecting the normal operation after the rainfall. In contrast, the primary sedimentation tank showed strong impact resistance with higher removal rates of COD, TSS, and ISS. Nonetheless, the primary settling tank aggravates the removal of organic carbon in sewage during rainfall, having a negative impact on subsequent biological treatment. The ISS in the surface runoff could increase the sludge concentration and decrease the MLVSS/MLSS ratio. After repeated surface runoff impact, the MLVSS/MLSS ratio in the activated sludge would drop below even 0.3, interrupting the normal operation of WWTP.

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“…The largest differences in transcriptomic profiles were observed between clams from the reference clean site and those exposed to wastewater treatment plant effluents. Most of the differentially expressed transcripts were involved in signaling pathways involved in energy metabolism suggesting an energy/nutrient deficit and hypoxic conditions in response to the pollutants in the effluents [ 175 ].…”

Section: Genomics and Bioinformatics Approaches In Endocrine Disruptor Researchmentioning

confidence: 99%

Integrated Genomic and Bioinformatics Approaches to Identify Molecular Links between Endocrine Disruptors and Adverse Outcomes

Verga

Huff

Owens

et al. 2022

IJERPH

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Exposure to Endocrine Disrupting Chemicals (EDC) has been linked with several adverse outcomes. In this review, we examine EDCs that are pervasive in the environment and are of concern in the context of human, animal, and environmental health. We explore the consequences of EDC exposure on aquatic life, terrestrial animals, and humans. We focus on the exploitation of genomics technologies and in particular whole transcriptome sequencing. Genome-wide analyses using RNAseq provides snap shots of cellular, tissue and whole organism transcriptomes under normal physiological and EDC perturbed conditions. A global view of gene expression provides highly valuable information as it uncovers gene families or more specifically, pathways that are affected by EDC exposures, but also reveals those that are unaffected. Hypotheses about genes with unknown functions can also be formed by comparison of their expression levels with genes of known function. Risk assessment strategies leveraging genomic technologies and the development of toxicology databases are explored. Finally, we review how the Adverse Outcome Pathway (AOP) has exploited this high throughput data to provide a framework for toxicology studies.

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Whole-transcriptome response to wastewater treatment plant and stormwater effluents in the Asian clam, Corbicula fluminea

Cited by 23 publications

References 91 publications

Urban ecophysiology: beyond costs, stress and biomarkers

Urban ecophysiology: beyond costs, stress and biomarkers

The Shock Effect of Inorganic Suspended Solids in Surface Runoff on Wastewater Treatment Plant Performance

Integrated Genomic and Bioinformatics Approaches to Identify Molecular Links between Endocrine Disruptors and Adverse Outcomes

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