Whole Tooth Regeneration: Can Animal Studies be Translated into Clinical Application?

Furquim, Camila Pinheiro; Kumagai, Rose Yakushijin; Bustillos-Torrez, Willy; Meza‐Mauricio, Jonathan; Tanaka, Caio Junji; Santana, Veronica B; Retamal‐Valdes, Belén; Shibli, Jamil Awad

doi:10.1089/ten.tec.2022.0022

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…For instance, a metal or ceramic implant could be used to join a bioengineered tissue structures like a tooth crown or the periodontal ligament, or a prosthetic crown could be joined with a biologically regenerated tooth root, or “bio-root.” In the next several years, creating a complete tooth (a “bio-tooth”) from scratch utilizing just cells and tissues is most likely the aim. This approach is still challenging inspite of the advancements in the basic and translational research [ 34 , 52 – 55 ].…”

Section: Discussionmentioning

confidence: 99%

Tissue Regeneration on Rise: Dental Hard Tissue Regeneration and Challenges—A Narrative Review

Alnasser,

Alshammari,

Siddiqui

et al. 2024

Scientifica

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Background. As people live longer, there is an increasing need for hard tissue regeneration and whole-tooth regeneration. Despite the advancements in the field of medicine, the field of regenerative dentistry is still challenging due to the complexity of dental hard tissues. Cross-disciplinary collaboration among material scientists, cellular biologists, and odontologists aimed at developing strategies and uncovering solutions related to dental tissue regeneration. Methodology. A search of the literature was done for pertinent research. Consistent with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 Statement, the electronic databases looked at were PubMed, Science Direct, Scopus, and Google Scholar, with the keyword search “hard dental tissue regeneration.” Results. Database analysis yielded a total of 476 articles. 222 duplicate articles have been removed in total. Articles that have no connection to the directed regeneration of hard dental tissue were disregarded. The review concluded with the inclusion of four studies that were relevant to our research objective. Conclusion. Current molecular signaling network investigations and novel viewpoints on cellular heterogeneity have made advancements in understanding of the kinetics of dental hard tissue regeneration possible. Here, we outline the fundamentals of stem hard dental tissue maintenance, regeneration, and repair, as well as recent advancements in the field of hard tissue regeneration. These intriguing findings help establish a framework that will eventually enable basic research findings to be utilized towards oral health-improving medicines.

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Section: Discussionmentioning

confidence: 99%

Tissue Regeneration on Rise: Dental Hard Tissue Regeneration and Challenges—A Narrative Review

Alnasser,

Alshammari,

Siddiqui

et al. 2024

Scientifica

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“…The first strategy is a combination of mesenchymal and epithelial cells to construct a bioengineered tooth germ, which is then transplanted into the alveolar socket. Parts of animals showed whole-tooth eruption around 3.5 mo after tooth-germ implantation[ 70 ]. However, several barriers should be addressed in future studies of bioengineered teeth, such as indiscriminate shape and smaller size than natural teeth[ 4 , 70 - 73 ].…”

Section: Oral Diseases and Functional Unit Regeneration Via...mentioning

confidence: 99%

“…Parts of animals showed whole-tooth eruption around 3.5 mo after tooth-germ implantation[ 70 ]. However, several barriers should be addressed in future studies of bioengineered teeth, such as indiscriminate shape and smaller size than natural teeth[ 4 , 70 - 73 ]. The second strategy includes the direct reconstruction of the functional units, such as bio-tooth root with periodontal tissue-like structures and dentin-pulp-like tissues.…”

Section: Oral Diseases and Functional Unit Regeneration Via...mentioning

confidence: 99%

Clinical application prospects and transformation value of dental follicle stem cells in oral and neurological diseases

Yang¹,

Du²,

Luo³

2023

World J Stem Cells

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Since dental pulp stem cells (DPSCs) were first reported, six types of dental SCs (DSCs) have been isolated and identified. DSCs originating from the craniofacial neural crest exhibit dental-like tissue differentiation potential and neuro-ectodermal features. As a member of DSCs, dental follicle SCs (DFSCs) are the only cell type obtained at the early developing stage of the tooth prior to eruption. Dental follicle tissue has the distinct advantage of large tissue volume compared with other dental tissues, which is a prerequisite for obtaining a sufficient number of cells to meet the needs of clinical applications. Furthermore, DFSCs exhibit a significantly higher cell proliferation rate, higher colony-formation capacity, and more primitive and better anti-inflammatory effects than other DSCs. In this respect, DFSCs have the potential to be of great clinical significance and translational value in oral and neurological diseases, with natural advantages based on their origin. Lastly, cryopreservation preserves the biological properties of DFSCs and enables them to be used as off-shelf products for clinical applications. This review summarizes and comments on the properties, application potential, and clinical transformation value of DFSCs, thereby inspiring novel perspectives in the future treatment of oral and neurological diseases.

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DLP 3D printing of high-resolution root scaffold with bionic bioactivity and biomechanics for personalized bio-root regeneration

Chen

Gui

Qiu

et al. 2023

Biomaterials Advances

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Whole Tooth Regeneration: Can Animal Studies be Translated into Clinical Application?

Cited by 4 publications

References 36 publications

Tissue Regeneration on Rise: Dental Hard Tissue Regeneration and Challenges—A Narrative Review

Tissue Regeneration on Rise: Dental Hard Tissue Regeneration and Challenges—A Narrative Review

Clinical application prospects and transformation value of dental follicle stem cells in oral and neurological diseases

DLP 3D printing of high-resolution root scaffold with bionic bioactivity and biomechanics for personalized bio-root regeneration

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