Whole Left Ventricular Coverage Versus Conventional 3-Slice Myocardial Perfusion Magnetic Resonance Imaging for the Detection of Suspected Coronary Artery Disease

Ma, Heng; Zhang, Yue; Chen, Jingjing; Jun, Yang

doi:10.1016/j.acra.2018.05.008

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…3,4 Enabling full left ventricular (LV) coverage for CMR perfusion is desirable to improve the assessment of myocardial ischemic burden, 5,6 which has demonstrated important prognostic value. 7 Previous studies have shown that increased spatial coverage may also improve detection of coronary artery disease 8 and in particular, detection of apical perfusion defects. 9 Finally, full LV coverage could improve simultaneous assessment of ischemia and infarction when combined with late gadolinium enhancement imaging.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous multislice steady‐state free precession myocardial perfusion with full left ventricular coverage and high resolution at 1.5 T

McElroy

Ferrazzi

Nazir

et al. 2022

Magnetic Resonance in Med

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To implement and evaluate a simultaneous multi-slice balanced SSFP (SMS-bSSFP) perfusion sequence and compressed sensing reconstruction for cardiac MR perfusion imaging with full left ventricular (LV) coverage (nine slices/heartbeat) and high spatial resolution (1.4 × 1.4 mm 2 ) at 1.5T. Methods:A preliminary study was performed to evaluate the performance of blipped controlled aliasing in parallel imaging (CAIPI) and RF-CAIPI with gradient-controlled local Larmor adjustment (GC-LOLA) in the presence of fat. A nine-slice SMS-bSSFP sequence using RF-CAIPI with GC-LOLA with high spatial resolution (1.4 × 1.4 mm 2 ) and a conventional three-slice sequence with conventional spatial resolution (1.9 × 1.9 mm 2 ) were then acquired in 10 patients under rest conditions. Qualitative assessment was performed to assess image quality and perceived signal-to-noise ratio (SNR) on a 4-point scale (0: poor image quality/low SNR; 3: excellent image quality/high SNR), and the number of myocardial segments with diagnostic image quality was recorded. Quantitative measurements of myocardial sharpness and upslope index were performed.Results: Fat signal leakage was significantly higher for blipped CAIPI than for RF-CAIPI with GC-LOLA (7.9% vs. 1.2%, p = 0.010). All 10 SMS-bSSFP perfusion datasets resulted in 16/16 diagnostic myocardial segments. There were no significant differences between the SMS and conventional acquisitions in terms of image quality (2.6 ± 0.6 vs. 2.7 ± 0.2, p = 0.8) or perceived SNR (2.8 ± 0.3 vs. 2.7 ± 0.3, p = 0.3). Inter-reader variability was good for both image quality (ICC = 0.84) and perceived SNR (ICC = 0.70). Myocardial sharpness was improved using the SMS sequence compared to the conventional Sarah McElroy and Giulio Ferrazzi contributed equally to this work.

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Section: Introductionmentioning

confidence: 99%

Simultaneous multislice steady‐state free precession myocardial perfusion with full left ventricular coverage and high resolution at 1.5 T

McElroy

Ferrazzi

Nazir

et al. 2022

Magnetic Resonance in Med

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“…CPT was performed in combination with different imaging modalities such as positron emission tomography (PET) [ 1 , 10 – 13 ], single photon emission computed tomography (SPECT) [ 14 ] or magnetic resonance imaging (MRI) [ 10 , 15 – 19 ]. Magnetic resonance imaging has been widely used to investigate myocardial perfusion in the past with both a technical [ 20 – 25 ] and also a clinical focus [ 26 – 29 ]. Additionally, endothelium-dependent and endothelium-independent MBF reserve has been investigated via CPT and adenosine stress test in an MRI setting [ 30 – 32 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of short-term smoking & L-arginine on coronary endothelial function assessed by cardiac magnetic resonance cold pressor testing: a pilot study

Weng

Köstler

Bley

et al. 2021

BMC Cardiovasc Disord

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Background The effect of smoking on coronary vasomotion has been investigated in the past with various imaging techniques in both short- and long-term smokers. Additionally, coronary vasomotion has been shown to be normalized in long-term smokers by L-Arginine acting as a substrate for NO synthase, revealing the coronary endothelium as the major site of abnormal vasomotor response. Aim of the prospective cohort study was to investigate coronary vasomotion of young healthy short-term smokers via magnetic resonance cold pressor test with and without the administration of L-Arginine and compare obtained results with the ones from nonsmokers. Methods Myocardial blood flow (MBF) was quantified with first-pass perfusion MRI on a 1.5 T scanner in healthy short-term smokers (N = 10, age: 25.0 ± 2.8 years, 5.0 ± 2.9 pack years) and nonsmokers (N = 10, age: 34.3 ± 13.6) both at rest and during cold pressor test (CPT). Smokers underwent an additional examination after administration of L-Arginine within a median of 7 days of the naïve examination. Results MBF at rest turned out to be 0.77 ± 0.30 (smokers with no L-Arginine; mean ± standard deviation), 0.66 ± 0.21 (smokers L-Arginine) and 0.84 ± 0.08 (nonsmokers). Values under CPT were 1.21 ± 0.42 (smokers no L-Arginine), 1.09 ± 0.35 (smokers L-Arginine) and 1.63 ± 0.33 (nonsmokers). In all groups, MBF was significantly increased under CPT compared to the corresponding rest examination (p < 0.05 in all cases). Additionally, MBF under CPT was significantly different between the smokers and the nonsmokers (p = 0.002). MBF at rest was significantly different between the smokers when L-Arginine was given and the nonsmokers (p = 0.035). Conclusion Short-term smokers showed a reduced response to cold both with and without the administration of L-Arginine. However, absolute MBF values under CPT were lower compared to nonsmokers independently of L-Arginine administration.

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“…Seeing a perfusion deficit in two different views could increase confidence in reading the scan. Also a recent retrospective study using SPECT perfusion images pointed out that a conventional three slice acquisition is likely to fail to detect ischemia in the apical myocardium [7], and another study concluded that whole left ventricle coverage (6 SA slices) improves the accuracy in detection of coronary artery disease compared with acquiring 3 SA slices [8]. Acquiring full left ventricle coverage by SA slices and LA slices is of great interest; LA slices can probe part or all of the apical myocardium and full coverage of the 17 myocardial segments suggested by the American Heart Association [9] can be achieved.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of multiple-view myocardial perfusion MRI using radial simultaneous multi-slice acquisitions

et al. 2019

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PurposeDynamic contrast enhanced MRI of the heart typically acquires 2–4 short-axis (SA) slices to detect and characterize coronary artery disease. This acquisition scheme is limited by incomplete coverage of the left ventricle. We studied the feasibility of using radial simultaneous multi-slice (SMS) technique to achieve SA, 2-chamber and/or 4-chamber long-axis (2CH LA and/or 4CH LA) coverage with and without electrocardiography (ECG) gating using a motion-robust reconstruction framework.Methods12 subjects were scanned at rest and/or stress, free breathing, with or without ECG gating. Multiple sets of radial SMS k-space were acquired within each cardiac cycle, and each SMS set sampled 3 parallel slices that were either SA, 2CH LA, or 4CH LA slices. The radial data was interpolated onto Cartesian space using an SMS GRAPPA operator gridding method. Self-gating and respiratory states binning of the data were done. The binning information as well as a pixel tracking spatiotemporal constrained reconstruction method were applied to obtain motion-robust image reconstructions. Reconstructions with and without the pixel tracking method were compared for signal-to-noise ratio and contrast-to-noise ratio.ResultsFull coverage of the heart (at least 3 SA and 3 LA slices) during the first pass of contrast at every heartbeat was achieved by using the radial SMS acquisition. The proposed pixel tracking reconstruction improves the average SNR and CNR by 21% and 30% respectively, and reduces temporal blurring for both gated and ungated acquisitions.ConclusionAcquiring simultaneous multi-slice SA, 2CH LA and/or 4CH LA myocardial perfusion images in every heartbeat is feasible in both gated and ungated acquisitions. This can add confidence when detecting and characterizing coronary artery disease by revealing ischemia in different views, and by providing apical coverage that is improved relative to SA slices alone. The proposed pixel tracking framework improves the reconstruction while adding little computational cost.

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Whole Left Ventricular Coverage Versus Conventional 3-Slice Myocardial Perfusion Magnetic Resonance Imaging for the Detection of Suspected Coronary Artery Disease

Cited by 4 publications

References 27 publications

Simultaneous multislice steady‐state free precession myocardial perfusion with full left ventricular coverage and high resolution at 1.5 T

Simultaneous multislice steady‐state free precession myocardial perfusion with full left ventricular coverage and high resolution at 1.5 T

Effect of short-term smoking & L-arginine on coronary endothelial function assessed by cardiac magnetic resonance cold pressor testing: a pilot study

Feasibility of multiple-view myocardial perfusion MRI using radial simultaneous multi-slice acquisitions

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