Whole genome sequencing reveals two genetically distinct <scp>MRSA</scp> outbreaks among people who inject drugs and homeless people in Copenhagen

Bartels, Mette Damkjær; Holm, Mona Katrine Alberthe; Worning, Peder; Stavad, Bodil; Schneider, Uffe Vest; Meiniche, Heidi; Thiesen, Henrik; Westh, Henrik

doi:10.1111/apm.13318

Cited by 2 publications

(1 citation statement)

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“…Amongst people who inject drugs, changes in clones of bacteria and the prevalence of resistant organisms such as methicillin‐resistant Staphylococcus aureus (MRSA) are of increasing concern. Clonal expansion of S. aureus and Streptococcus pyogenes have contributed to outbreaks of acute infections in people who inject drugs in the United Kingdom and Europe [ 65 , 66 , 67 ]. Furthermore, acute infections due to MRSA have been increasingly reported in people who inject drugs in North America and Europe, with concerns around shifts in population structures of MRSA clones [ 66 , 68 , 69 ].…”

Section: Factors Contributing To the Increase In Acute Infections In ...mentioning

confidence: 99%

Epidemiology of acute infections in people who inject drugs in Australia

Attwood,

O'Keefe,

Higgs

et al. 2023

Drug and Alcohol Review

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IssuesPeople who inject drugs are at risk of acute infections, such as skin and soft tissue infections, infective endocarditis, bone and joint infections and bloodstream infections. There has been an increase in these infections in people who inject drugs internationally over the past 10 years. However, the local data regarding acute infections in Australia has not been well described.ApproachWe review the epidemiology of acute infections and associated morbidity and mortality amongst people who inject drugs in Australia. We summarise risk factors for these infections, including the concurrent social and psychological determinants of health.Key FindingsThe proportion of people who report having injected drugs in the prior 12 months in Australia has decreased over the past 18 years. However, there has been an increase in the burden of acute infections in this population. This increase is driven largely by skin and soft tissue infections. People who inject drugs often have multiple conflicting priorities that can delay engagement in care.ImplicationsAcute infections in people who inject drugs are associated with significant morbidity and mortality. Acute infections contribute to significant bed days, surgical requirements and health‐care costs in Australia. The increase in these infections is likely due to a complex interplay of microbiological, individual, social and environmental factors.ConclusionAcute infections in people who inject drugs in Australia represent a significant burden to both patients and health‐care systems. Flexible health‐care models, such as low‐threshold wound clinics, would help directly target, and address early interventions, for these infections.

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