Whole-Genome Sequencing of Lysobacter capsici VKM B-2533
            <sup>T</sup>
            and Lysobacter gummosus 10.1.1, Promising Producers of Lytic Agents

Tarlachkov, Sergey V.; Kudryakova, Irina V.; Afoshin, Alexey S.; Leontyevskaya, Elena A.; Vasilyeva, Natalia V.

doi:10.1128/mra.00484-22

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2023

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“…The strain has been shown to possess antibacterial and antifungal activities [19]. We have recently sequenced the DNA of L. gummosus 10.1.1 and have assembled its genome in the form of a ring chromosome [21]. The present work continues the characterization of this strain, a potential producer of valuable antimicrobial agents.…”

Section: Introductionmentioning

confidence: 73%

Lysobacter gummosus 10.1.1, a Producer of Antimicrobial Agents

Kudryakova,

Afoshin,

Tarlachkov

et al. 2023

Microorganisms

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This work investigated the antimicrobial potential of Lysobacter gummosus 10.1.1. The culture fluid of the strain was found to contain antimicrobial agents active against Staphylococcus aureus, Micrococcus luteus, and Bacillus cereus. L. gummosus was first shown to be capable of forming outer membrane vesicles, which have a bacteriolytic effect against not only Gram-positive bacteria but also against the Gram-negative pathogen Pseudomonas aeruginosa. Transcriptomic analysis revealed the genes of almost all known bacteriolytic enzymes of Lysobacter, as well as the genes of enzymes with putative bacteriolytic activity. Also identified were genes involved in the biosynthesis of a number of secondary metabolites for which antimicrobial activities are known. This research is indicative of the relevance of isolating and studying L. gummosus antimicrobial agents.

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Section: Introductionmentioning

confidence: 73%