Whole-genome sequences reveal zygotic composition in chimeric twins
Christopher J. Yoon,
Chang Hyun Nam,
Taewoo Kim
et al.
Abstract:SummaryThe monochorionic placenta in dizygotic twins allowsin uteroexchange of embryonic cells, resulting in chimerism in the twins. In practice, this chimerism is incidentally identified on mixed ABO blood types or in the presence of cells with a discordant sex chromosome. Here, we applied whole-genome sequencing to one triplet and one twin families to precisely understand their zygotic compositions, using millions of genomic variants as barcodes of zygotic origins. Peripheral blood showed asymmetrical contri… Show more
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