Whole genome sequence of an edible and potential medicinal fungus, <i>Cordyceps guangdongensis</i>

Zhang, Chenghua; Deng, Wang-Qiu; Yan, Wenjuan; Li, Tai–Hui

doi:10.1101/254243

Cited by 2 publications

(2 citation statements)

References 43 publications

(44 reference statements)

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“…The cordycipitoid genus Tolypocladium (Ophiocordycipitaceae, Hypocreales) was erected by the type species T. inflatium. Several species of Tolypocladium are medicinally and economically important due to the production of Cyclosporin A with antifungal activity and as immunosuppressant drug (Samson and Soares 1984;Li 1988;Bushley et al 2013;Quandt et al 2015, Rocha et al 2015Yang et al 2018;Zhang et al 2018). Due to the importance of Tolypocladium for mycology, medicine and ecology, more research is necessary to obtain genomic information of this lineage.…”

Section: Mitochondrial Genome; Phylogenetic Analysis; Tolypocladiummentioning

confidence: 99%

Complete mitochondrial genome ofTolypocladiumsp. YFCC 1805002 isolated fromOphiocordyceps sinensisin Baima Snow Mountain, Southwestern China

Liu

Tang

Zhang

et al. 2019

Mitochondrial DNA Part B

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Tolypocladium sp. YFCC 1805002, an undescribed species isolated from natural Ophiocordyces sinensis in Baima Snow Mountain, Deqin County of Yunnan in Southwestern China, was sequenced on the Illumina sequencing platform. The complete mitochondrial genome of this fungus is a circular molecule of 46,466 bp in length, and this value is higher than its two relatives T. inflatum and T. ophioglossoides . The circular mitogenome contains 15 protein-coding genes (PCGs), a set of 25 transfer RNA (tRNA) genes, and 2 ribosomal RNA (rns and rnl) genes. The 15 protein-coding genes are atp6 , 8–9 , cob , cox1–3 , nad1–6 , nad4L and rps3 . The lengths of 25 transfer RNA (tRNA) genes are ranging from 71 to 87 bp, and the sizes of rns and rnl are 1554 bp and 5931 bp, respectively. The overall base composition is 38.3% A, 35.6% T, 11.6% C, 14.5% G, with a low GC content of 26.1%. Phylogenetic analysis inferred from concatenated protein-coding genes of 51 taxa shows that the new species Tolypocladium sp. YFCC 1805002 is closely related to T. inflatum in the family Ophiocordycipitaceae with high credible support by Bayesian inference posterior probabilities (BI-PP = 100%). This study would facilitate the future research of genetics, evolution and medicine of cordycipitoid fungi.

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Section: Mitochondrial Genome; Phylogenetic Analysis; Tolypocladiummentioning

confidence: 99%

Complete mitochondrial genome ofTolypocladiumsp. YFCC 1805002 isolated fromOphiocordyceps sinensisin Baima Snow Mountain, Southwestern China

Liu

Tang

Zhang

et al. 2019

Mitochondrial DNA Part B

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“…With the development of next-generation sequencing technology ( Ansorge, 2009 ), omics technology provides a valid and comprehensive method for us to widely study the genetic basis in several sclerotium-producing mushrooms, such as Wolfiporia cocos ( Zhang et al, 2016 ), Lignosus rhinocerotis ( Yap et al, 2014 ), Ophiocordyceps sinensis ( Li et al, 2016 ), and Cordyceps guangdongensis ( Zhang C. et al, 2018 ). Genome and transcriptome dissection offer powerful and effective approaches that result in the identification and characterization of diverse genes in mushrooms related to metabolites, growth and development, and response to environments ( Yap et al, 2014 ; Kramer and Nodwell, 2017 ; Gupta et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Genome and Comparative Transcriptome Dissection Provide Insights Into Molecular Mechanisms of Sclerotium Formation in Culinary-Medicinal Mushroom Pleurotus tuber-regium

Sun

Zhang

et al. 2022

Front. Microbiol.

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Pleurotus tuber-regium is an edible and medicinal sclerotium-producing mushroom. The sclerotia of this mushroom also serve as food and folk medicine. Based on the description of its monokaryon genome, sequenced with Illumina and PacBio sequencing technologies, comparative transcriptomic analysis using RNA sequencing (RNA-seq) was employed to study its mechanism of sclerotium formation. The de novo assembled genome is 35.82 Mb in size with a N50 scaffold size of 4.29 Mb and encodes 12,173 putative proteins. Expression analysis demonstrated that 1,146 and 1,249 genes were upregulated and downregulated with the formation of sclerotia, respectively. The differentially expressed genes were associated with substrate decomposition, the oxidation-reduction process, cell wall synthesis, and other biological processes in P. tuber-regium. These genomic and transcriptomic resources provide useful information for the mechanism underlying sclerotium formation in P. tuber-regium.

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Whole genome sequence of an edible and potential medicinal fungus, Cordyceps guangdongensis

Abstract: 37Cordyceps guangdongensis is an edible fungus which has been approved as a

Cited by 2 publications

References 43 publications

Complete mitochondrial genome ofTolypocladiumsp. YFCC 1805002 isolated fromOphiocordyceps sinensisin Baima Snow Mountain, Southwestern China

Complete mitochondrial genome ofTolypocladiumsp. YFCC 1805002 isolated fromOphiocordyceps sinensisin Baima Snow Mountain, Southwestern China

Genome and Comparative Transcriptome Dissection Provide Insights Into Molecular Mechanisms of Sclerotium Formation in Culinary-Medicinal Mushroom Pleurotus tuber-regium

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