2019
DOI: 10.1099/mgen.0.000250
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Whole genome sequence analysis of Australian avian pathogenic Escherichia coli that carry the class 1 integrase gene

Abstract: Avian pathogenic Escherichia coli (APEC) cause widespread economic losses in poultry production and are potential zoonotic pathogens. Genome sequences of 95 APEC from commercial poultry operations in four Australian states that carried the class 1 integrase gene intI1, a proxy for multiple drug resistance (MDR), were characterized. Sequence types ST117 (22/95), ST350 (10/95), ST429 and ST57 (each 9/95), ST95 (8/95) and ST973 (7/95) dominated, while 24 STs were represented by one or two strains. FII and FIB rep… Show more

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Cited by 57 publications
(89 citation statements)
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References 104 publications
(75 reference statements)
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“…The sul3 gene was first described in pigs (Perreten and Boerlin, 2003) and has since been reported widely in association with Enterobacteriaceae in humans, farm animals and their wasteparticularly swine (Antunes et al, 2007;Phuong Hoa et al, 2008;Byrne-Bailey et al, 2009;Curiao et al, 2011;Moran et al, 2016). In Australia and elsewhere, sul3 is identified frequently in commensal E. coli from the feces of swine (Guerra et al, 2004;Bischoff et al, 2005;Reid et al, 2017) but less frequently in avian pathogenic E. coli (APEC) from diverse poultry production systems in Australia (Cummins et al, 2019). These observations suggest that swine production, and food animal production more broadly, plays a major role in the evolution of IncHI2 ST3 plasmids that carry sul3.…”
Section: Discussionmentioning
confidence: 99%
“…The sul3 gene was first described in pigs (Perreten and Boerlin, 2003) and has since been reported widely in association with Enterobacteriaceae in humans, farm animals and their wasteparticularly swine (Antunes et al, 2007;Phuong Hoa et al, 2008;Byrne-Bailey et al, 2009;Curiao et al, 2011;Moran et al, 2016). In Australia and elsewhere, sul3 is identified frequently in commensal E. coli from the feces of swine (Guerra et al, 2004;Bischoff et al, 2005;Reid et al, 2017) but less frequently in avian pathogenic E. coli (APEC) from diverse poultry production systems in Australia (Cummins et al, 2019). These observations suggest that swine production, and food animal production more broadly, plays a major role in the evolution of IncHI2 ST3 plasmids that carry sul3.…”
Section: Discussionmentioning
confidence: 99%
“…Two isolates were assigned to ST117 (phylogenetic group F). Recent studies indicate that this sequence type comprises important APEC lineages that are repeatedly reported from colibacillosis outbreaks in different countries (25,37,(40)(41)(42), but are also highlighted as potential zoonotic pathogens for containing ExPEC-related virulence genes and being isolated from both retail poultry meat and human clinical urinary tract infections (43). The remaining phylogroup F isolate was ST354, another potentially zoonotic ST, reported particularly from human and animal healthcare facilities and characterized by common resistance to antimicrobials including fluoroquinolones (44,45).…”
Section: Discussionmentioning
confidence: 99%
“…Two isolates were assigned to ST117 (phylogenetic group F). Recent studies indicate that this sequence type comprises an important APEC lineages that are repeatedly reported from colibacillosis outbreaks in different countries (25,37,(40)(41)(42), but are also highlighted as potential zoonotic pathogens for containing ExPEC-related virulence genes and being isolated from both retail poultry meat and human clinical urinary tract infections (43). The remaining phylogroup F isolate was ST354, another potentially zoonotic ST, reported particularly from human and animal healthcare facilities and characterized by common resistance to antimicrobials including fluoroquinolones (44,45).…”
Section: Discussionmentioning
confidence: 99%
“…Both ST429 and ST23 are considered as predominant APEC lineages that are frequently isolated from poultry with clinically manifested disease (35,37), but also poultry products (26). Although representing quite unrelated APEC clades, they both appear to be poultry-specific, with little pathogenic potential for humans (7,17).…”
Section: Discussionmentioning
confidence: 99%