Whole-genome characterization of avian picornaviruses from diarrheic broiler chickens co-infected with multiple picornaviruses in Iran

Zamani, Niusha Haji; Hosseini, Hossein; Kafi, Zahra Ziafati; Sadri, Naser; Rajeoni, Ali Hojabr; Dizaji, Reza Esmaeelzadeh; Molouki, Aidin; FallahMehrabadi, Mohammad Hossein; Abdoshah, Mohammad; Ghalyanchilangeroudi, Arash

doi:10.1007/s11262-022-01938-0

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…Members of picornaviruses contains diverse non-enveloped, positive ssRNA viruses with a genome of 7–9 kb in length,which may cause various diseases in different vertebrate hosts, including enteric diseases [ 20 , 21 ]. Of particular note is the discovery of picornaviruses both in the tissues and feces samples in this study, and a nearly complete genome of picornavirus was identified in the tissues.…”

Section: Discussionmentioning

confidence: 99%

Virome characterization of diarrheic red-crowned crane (G. japonensis)

Cui,

Yang,

Sui

et al. 2024

anim microbiome

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Background The red-crowned crane is one of the vulnerable bird species. Although the captive population has markedly increased over the last decade, infectious diseases can lead to the death of young red-crowned cranes while few virological studies have been conducted. Methods Using a viral metagenomics approach, we analyzed the virome of tissues of the dead captive red-crowned crane with diarrhea symptoms in Dongying Biosphere Reserve, Shandong Province, China and feces of individual birds breeding at the corresponding captive breeding center, which were pooled separately. Results There is much more DNA and RNA viruses in the feces than that of the tissues. RNA virus belonging to the families Picornaviridae, and DNA viruses belonging to the families Parvoviridae, associated with enteric diseases were detected in the tissues and feces. Genomes of the picornavirus, genomovirus, and parvovirus identified in the study were fully characterized, which further suggested that infectious viruses of these families were possibly presented in the diseased red-crowned crane. Conclusion RNA virus belonging to the families Picornaviridae, and DNA viruses belonging to the families Genomoviridae and Parvoviridae were possibly the causative agent for diarrhea of red-crowned crane. This study has expanded our understanding of the virome of red-crowned crane and provides a baseline for elucidating the etiology for diarrhea of the birds.

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Section: Discussionmentioning

confidence: 99%

Virome characterization of diarrheic red-crowned crane (G. japonensis)

Cui,

Yang,

Sui

et al. 2024

anim microbiome

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“…The genus Megrivirus, recognized to contain one of the longest picornaviral genomes currently described, comprises five species, named A to E. The type IV IRES is present in the 5' UTR region of all species, with the sole exception of species D (Honkavuori et al, 2011;Phan et al, 2013;Lau et al, 2014;Liao et al, 2014;Boros et al, 2014a;Kim et al, 2015;Wang et al, 2017;Zell, 2018;Yinda et al, 2019;Haji Zamani et al, 2023). This type of virus is additionally found in migrant bird (genus Kunsagivirus) (Boros et al, 2013), pigeon (genus Colbovirus) (Kofstad and Jonassen, 2011), quail (genus Phacovirus) (Pankovics et al, 2012), goose (genus Ludopivirus) (Boros et al, 2018), duck (Pinkeared duck picornavirus), red-crowned crane (genus Grusopivirus) (Wang Y. et al, 2019;Arhab et al, 2020), lorikeet (genus Grusopivirus) (Wang et al, 2019a), as well as other species, such as amphibians, reptiles (Ng et al, 2015;Arhab et al, 2020) and fishes (Table 1) (Barbknecht et al, 2014;Lange et al, 2014;Phelps et al, 2014;Asnani et al, 2015).…”

Section: Identification Of Type IV Ires In Picornavirusesmentioning

confidence: 99%

Structure and function of type IV IRES in picornaviruses: a systematic review

Li,

Zhang,

Wang

et al. 2024

Front. Microbiol.

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The Picornaviridae is a family of icosahedral viruses with single-stranded, highly diverse positive-sense RNA genomes. Virions consist of a capsid, without envelope, surrounding a core of RNA genome. A typical genome of picornavirus harbors a well-conserved and highly structured RNA element known as the internal ribosome entry site (IRES), functionally essential for viral replication and protein translation. Based on differences in their structures and mechanisms of action, picornaviral IRESs have been categorized into five types: type I, II, III, IV, and V. Compared with the type IV IRES, the others not only are structurally complicated, but also involve multiple initiation factors for triggering protein translation. The type IV IRES, often referred to as hepatitis C virus (HCV)-like IRES due to its structural resemblance to the HCV IRES, exhibits a simpler and more compact structure than those of the other four. The increasing identification of picornaviruses with the type IV IRES suggests that this IRES type seems to reveal strong retention and adaptation in terms of viral evolution. Here, we systematically reviewed structural features and biological functions of the type IV IRES in picornaviruses. A comprehensive understanding of the roles of type IV IRESs will contribute to elucidating the replication mechanism and pathogenesis of picornaviruses.

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Identification and characterization of multiple novel picornaviruses in fecal samples of bar-headed goose

Sun,

Wang,

et al. 2024

Front. Microbiol.

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IntroductionThe bar-headed goose (Anser indicus), one of the most well-known high-altitude birds, is renowned for its adaptation to high-altitude environments. Previous studies have shown that they can be infected with highly pathogenic avian influenza; however, there is currently limited research on other viruses in bar-headed geese.MethodsIn this study, 10 fecal samples of healthy bar-headed geese were collected, and viral metagenomics method was conducted to identify novel picornaviruses.ResultsSeven novel picornaviruses were identified in the fecal samples of bar-headed geese. Most of these picornaviruses were genetically different from other currently known viruses in the NCBI dataset. Among them, PICV4 was determined to be a new species belonging to the Anativirus genus, PICV5 and PICV13 were classified as novel species belonging to the Hepatovirus genus, and the remaining four picornaviruses (PICV1, PICV19, PICV21, and PICV22) were identified as part of the Megrivirus A species of the Megrivirus genus. Recombinant analysis indicates that PICV21 was a potential recombinant, and the major and minor parents were PICV1 and PICV22, respectively.ConclusionThe findings of this study increase our understanding of the diversity of picornaviruses in bar-headed geese and provide practical viral genome information for the prevention and treatment of potential viral diseases affecting this species.

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Whole-genome characterization of avian picornaviruses from diarrheic broiler chickens co-infected with multiple picornaviruses in Iran

Cited by 3 publications

References 34 publications

Virome characterization of diarrheic red-crowned crane (G. japonensis)

Virome characterization of diarrheic red-crowned crane (G. japonensis)

Structure and function of type IV IRES in picornaviruses: a systematic review

Identification and characterization of multiple novel picornaviruses in fecal samples of bar-headed goose

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