2011
DOI: 10.2527/jas.2010-3236
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Whole-genome association analyses for lifetime reproductive traits in the pig

Abstract: Profits for commercial pork producers vary in part because of sow productivity or sow productive life (SPL) and replacement costs. During the last decade, culling rates of sows have increased to more than 50% in the United States. Both SPL and culling rates are influenced by genetic and nongenetic factors. A whole-genome association study was conducted for pig lifetime reproductive traits, including lifetime total number born (LTNB), lifetime number born alive (LNBA), removal parity, and the ratio between life… Show more

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Cited by 81 publications
(72 citation statements)
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References 23 publications
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“…Contrary to what has been reported by Onteru et al (2011), where the implementation of survival models in GS is not yet possible, this study showed that for the method where the pedigree-based relationship matrix is replaced by a marker-based relationship matrix (GBLUP and GBLUP-D in linear models), fitting the Cox model can be conducted relatively simply, without the need for a large computational demand. Furthermore, the fit has allowed for the estimation of non-additive effects, such as the dominance effect.…”
Section: Discussionmentioning
confidence: 46%
“…Contrary to what has been reported by Onteru et al (2011), where the implementation of survival models in GS is not yet possible, this study showed that for the method where the pedigree-based relationship matrix is replaced by a marker-based relationship matrix (GBLUP and GBLUP-D in linear models), fitting the Cox model can be conducted relatively simply, without the need for a large computational demand. Furthermore, the fit has allowed for the estimation of non-additive effects, such as the dominance effect.…”
Section: Discussionmentioning
confidence: 46%
“…This may hinder the identification of true QTL Onteru et al, 2011). To accurately identify the presence of QTL, a sliding genomic window of five consecutive SNPs based on genomic location was used to predict the genomic breeding value of the region.…”
Section: Genotypic Datamentioning
confidence: 99%
“…This was achieved by summing the contribution of the SNPs to the genetic variance per window. This approach also helps control against false-positives arising from single putative SNPs Onteru et al, 2011).…”
Section: Genotypic Datamentioning
confidence: 99%
“…Solely on the basis of these fi ndings, selection for lower backfat thickness would not be expected to have great detrimental effects on longevity or lifetime reproductive performance. However, Onteru et al (2011) conducted a whole-genome association study on a subpopulation of the current data and the fi ndings reinforced the associations of fat regulation with longevity and lifetime reproductive traits. Stalder et al (2005) reported that BF10 was unfavorably associated with RP and LBA and proposed that some minimum level of backfat thickness may be essential for good lifetime reproduction.…”
Section: Genetic Correlationsmentioning
confidence: 99%