Whole-Exome sequencing analysis identified TMSB10/TRABD2A locus to be associated with carfilzomib-related cardiotoxicity among patients with multiple myeloma
Marwa Tantawy,
Guang Yang,
Raghunandan Reddy Algubelli
et al.
Abstract:BackgroundProteasome inhibitor Carfilzomib (CFZ) is effective in treating patients with refractory or relapsed multiple myeloma (MM) but has been associated with cardiovascular adverse events (CVAE) such as hypertension, cardiomyopathy, and heart failure. This study aimed to investigate the contribution of germline genetic variants in protein-coding genes in CFZ-CVAE among MM patients using whole-exome sequencing (WES) analysis.MethodsExome-wide single-variant association analysis, gene-based analysis, and rar… Show more
“…TMSB10 is a ubiquitous protein and member of the β-thymosin family and has been previously reported to be dysregulated in dilated cardiomyopathy. TRABD2A was previously associated with troponin elevation and heart failure (poster #11) [ 5 ].…”
Section: Summary Of Topics Presented In the Poster Sessionmentioning
“…TMSB10 is a ubiquitous protein and member of the β-thymosin family and has been previously reported to be dysregulated in dilated cardiomyopathy. TRABD2A was previously associated with troponin elevation and heart failure (poster #11) [ 5 ].…”
Section: Summary Of Topics Presented In the Poster Sessionmentioning
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