Whole-cell one-pot biosynthesis of dodecanedioic acid from renewable linoleic acid
Yi-Ke Qi,
Jiang Pan,
Zhi-Jun Zhang
et al.
Abstract:Background
Dodecanedioic acid (DDA), a typical medium-chain dicarboxylic fatty acid with widespread applications, has a great synthetic value and a huge industrial market demand. Currently, a sustainable, eco-friendly and efficient process is desired for dodecanedioic acid production.
Results
Herein, a multi-enzymatic cascade was designed and constructed for the production of DDA from linoleic acid based on the lipoxygenase pathway in plants. The c… Show more
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