Whole brain perfusion measurements using arterial spin labeling with multiband acquisition

Kim, Tae Il; Shin, Wanyong; Zhao, Tiejun; Beall, Erik B.; Lowe, Mark J.; Bae, Kyongtae T.

doi:10.1002/mrm.24880

Cited by 38 publications

(45 citation statements)

References 28 publications

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“…Although MB-EPI has been recently demonstrated (Kim et al, 2013) and compared to single-shot 3D GRASE for brain perfusion imaging using FAIR (Feinberg et al, 2013), we explored the potential benefit of MB-EPI in high-resolution whole brain pCASL imaging for the first time. We have demonstrated the impact of MB on ASL imaging both theoretically and experimentally, taking into account both the beneficial characteristics (improved imaging efficiency) and confounding effects (amplified thermal noise and leakage contamination).…”

Section: Discussionmentioning

confidence: 99%

“…MB-EPI has been recently demonstrated (Kim et al, 2013) and later compared to single-shot 3D GRASE (Feinberg et al, 2013) for PASL perfusion imaging in the brain using flow-sensitive alternating inversion recovery (FAIR) (Kim and Tsekos, 1997). By using a standard low imaging resolution, these studies found that perfusion signal differences between single-band (SB) and MB-EPI are minimal.…”

Section: Introductionmentioning

confidence: 99%

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Theoretical and experimental evaluation of multi-band EPI for high-resolution whole brain pCASL Imaging

Wang

Auerbach

et al. 2015

NeuroImage

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Multi-Band Echo Planar Imaging (MB-EPI), a new approach to increase data acquisition efficiency and/or temporal resolution, has the potential to overcome critical limitations of standard acquisition strategies for obtaining high-resolution whole brain perfusion imaging using arterial spin labeling (ASL). However, the use of MB also introduces confounding effects, such as spatially varying amplified thermal noise and leakage contamination, which have not been evaluated to date as to their effect on cerebral blood flow (CBF) estimation. In this study, both the potential benefits and confounding effects of MB-EPI were systematically evaluated through both simulation and experimentally using a pseudo-continuous arterial spin labeling (pCASL) strategy. These studies revealed that the amplified noise, given by the geometry factor (g-factor), and the leakage contamination, assessed by the total leakage factor (TLF), have minimal impact on CBF estimation. Furthermore, it is demonstrated that MB-EPI greatly benefits high-resolution whole brain pCASL studies in terms of improved spatial and temporal signal-to-noise ratio efficiency, and increases compliance with the assumptions of the commonly used single blood compartment model, resulting in improved CBF estimates.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Theoretical and experimental evaluation of multi-band EPI for high-resolution whole brain pCASL Imaging

Wang

Auerbach

et al. 2015

NeuroImage

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show abstract

“…High temporal resolution is particular important for rs-fMRI applications of ASL, and recently, simultaneous multi-slice or multiband (MB) imaging has been attempted in ASL perfusion MRI, showing promise. MB techniques can be used to simultaneously acquire multiple slices using composite RF pulses (Feinberg et al, 2011;Kim et al, 2013;Li et al, 2014). Compared to standard 2D EPI-based ASL, MB-EPI ASL can reduce T1 relaxation of the arterial label, improving spatial coverage and resolution with little SNR penalty.…”

Section: Multiband Aslmentioning

confidence: 99%

Characterizing Resting-State Brain Function Using Arterial Spin Labeling

2015

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Arterial spin labeling (ASL) is an increasingly established magnetic resonance imaging (MRI) technique that is finding broader applications in studying the healthy and diseased brain. This review addresses the use of ASL to assess brain function in the resting state. Following a brief technical description, we discuss the use of ASL in the following main categories: (1) resting-state functional connectivity (FC) measurement: the use of ASL-based cerebral blood flow (CBF) measurements as an alternative to the blood oxygen level-dependent (BOLD) technique to assess resting-state FC; (2) the link between network CBF and FC measurements: the use of network CBF as a surrogate of the metabolic activity within corresponding networks; and (3) the study of resting-state dynamic CBF-BOLD coupling and cerebral metabolism: the use of dynamic CBF information obtained using ASL to assess dynamic CBF-BOLD coupling and oxidative metabolism in the resting state. In addition, we summarize some future challenges and interesting research directions for ASL, including slice-accelerated (multiband) imaging as well as the effects of motion and other physiological confounds on perfusion-based FC measurement. In summary, this work reviews the state-of-the-art of ASL and establishes it as an increasingly viable MRI technique with high translational value in studying resting-state brain function.

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“…This is a parallel imaging technique that simultaneously excites multiple slices with a multiband excitation pulse and reads out these images in an echo train. This technique was incorporated in ASL with the aim of increasing spatial coverage without lengthening the time window of image readout within the capillary phase of blood circulation (124, 125). The application of this technique can be extended to any ASL variant, such as PASL, CASL, and PCASL.…”

Section: Introductionmentioning

confidence: 99%

Perfusion Magnetic Resonance Imaging: A Comprehensive Update on Principles and Techniques

et al. 2014

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Perfusion is a fundamental biological function that refers to the delivery of oxygen and nutrients to tissue by means of blood flow. Perfusion MRI is sensitive to microvasculature and has been applied in a wide variety of clinical applications, including the classification of tumors, identification of stroke regions, and characterization of other diseases. Perfusion MRI techniques are classified with or without using an exogenous contrast agent. Bolus methods, with injections of a contrast agent, provide better sensitivity with higher spatial resolution, and are therefore more widely used in clinical applications. However, arterial spin-labeling methods provide a unique opportunity to measure cerebral blood flow without requiring an exogenous contrast agent and have better accuracy for quantification. Importantly, MRI-based perfusion measurements are minimally invasive overall, and do not use any radiation and radioisotopes. In this review, we describe the principles and techniques of perfusion MRI. This review summarizes comprehensive updated knowledge on the physical principles and techniques of perfusion MRI.

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Whole brain perfusion measurements using arterial spin labeling with multiband acquisition

Abstract: The MB ASL technique is an effective method to evaluate whole brain perfusion because it minimizes the temporal spread of labeled spins across slices, resulting in more accurate perfusion measurements.

Cited by 38 publications

References 28 publications

Theoretical and experimental evaluation of multi-band EPI for high-resolution whole brain pCASL Imaging

Theoretical and experimental evaluation of multi-band EPI for high-resolution whole brain pCASL Imaging

Characterizing Resting-State Brain Function Using Arterial Spin Labeling

Perfusion Magnetic Resonance Imaging: A Comprehensive Update on Principles and Techniques

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