Whole-Brain Haemodynamic After-Effects of 1-Hz Magnetic Stimulation of the Posterior Superior Temporal Cortex During Action Observation

Arfeller, Carola; Schwarzbach, Jens; Ubaldi, Silvia; Ferrari, P.; Barchiesi, Guido; Cattaneo, Luigi

doi:10.1007/s10548-012-0239-9

Cited by 24 publications

(25 citation statements)

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“…This is clearly observed when coupling 1-Hz rTMS with a wholebrain measure such as fMRI. As reviewed in Arfeller et al (2013), the hemodynamic effects of 1-Hz rTMS on regions distant from the stimulated one are strictly task-dependent and can be, unpredictably, inhibitory or excitatory. Also in the specific field of brain responses to action observation, remote effects of 1-Hz rTMS on the mirror neuron circuit can be facilitatory after rTMS of the posterior superior temporal sulcus (Arfeller et al 2013;Avenanti et al 2013) or inhibitory after stimulation of the premotor cortex (Avenanti et al 2007).…”

Section: Discussionmentioning

confidence: 99%

“…As reviewed in Arfeller et al (2013), the hemodynamic effects of 1-Hz rTMS on regions distant from the stimulated one are strictly task-dependent and can be, unpredictably, inhibitory or excitatory. Also in the specific field of brain responses to action observation, remote effects of 1-Hz rTMS on the mirror neuron circuit can be facilitatory after rTMS of the posterior superior temporal sulcus (Arfeller et al 2013;Avenanti et al 2013) or inhibitory after stimulation of the premotor cortex (Avenanti et al 2007). The occurrence of facilitatory remote effects of 1-Hz rTMS is generally attributed to compensatory increase of the activity within a network in face of reduced functioning of the stimulated target (Avenanti et al 2013).…”

Section: Discussionmentioning

confidence: 99%

“…The low-intensity rTMS condition represents robust baseline measure because it accounts for all TMS effects that are not related to cortical stimulation, such as noise, cutaneous sensations, pain, weight, and position of the TMS coil. According to data obtained on the motor cortex, (Fitzgerald et al 2006), and on the temporal cortex (Arfeller et al 2013), intensities lower than 80% of RMTh should be ineffective. However, there are no available data in literature on how low should TMS intensity be, in order not to produce efficient stimulation of the parietal or prefrontal cortices with 1-Hz frequency.…”

Section: Methodsmentioning

confidence: 99%

“…In a second experiment, we explored with repetitive TMS (rTMS) the role of the putative human anterior intraparietal area ( phAIP) and of the dorsolateral prefrontal cortex (dlPFC) in generating automatic and rule-based responses. The reason for choosing the phAIP is that, in models of the action observation network, related to hand movements, this is the node that receives visual information from the occipito-temporal cortex and relays it to the premotor cortex (Cattaneo et al 2010;Arfeller et al 2013). For a review, see Cattaneo and Rizzolatti (2009).…”

Section: Introductionmentioning

confidence: 99%

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Bottom-Up and Top-Down Visuomotor Responses to Action Observation

2013

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Action observation produces automatic "mirror" responses in the observers' motor system. However, in daily life, nonimitative actions are often required to be produced in response to others' acts, generating a conflict between automatic and voluntary responses. First, we used single-pulse transcranial magnetic stimulation (TMS) to assess the temporal dynamics of motor output in healthy volunteers preparing rule-based counter-imitative motor responses cued by different observed hand movements. Second, we applied the same paradigm after 1-Hz repetitive TMS (rTMS) of the left posterior parietal cortex (PPC) and of the left dorsolateral prefrontal cortex (dlPFC). The results showed an early (150 ms from onset of visual stimuli) stimulus-driven mirror response that was followed by a later (300 ms) rule-based nonmirror response. rTMS applied to the PPC modulated only the early mirror response. Conversely, rTMS to the dlPFC modulated specifically the late rule-based motor response. The data indicate that a fast bottom-up process mediated by the dorsal visual stream produces automatic imitative responses. Arbitrary rule-based visuomotor associations are on the contrary mediated by a slower system, relying on the prefrontal cortex. The 2 systems are mutually independent and compete for motor output in socially relevant situations only at a distal level.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bottom-Up and Top-Down Visuomotor Responses to Action Observation

2013

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“…The crucial role played by each node of the AON in action representation, however, cannot be fully clarified by brain stimulation studies alone since the interference induced by single dose TMS of a given area might determine transient functional fluctuations of networks’ activity (Siebner et al, 2009; Avenanti et al, 2012a,b; Arfeller et al, 2013). It is likely that such transient instabilities trigger fast compensatory functional reorganization of the network (Arfeller et al, 2013; Avenanti et al, 2013a), as documented for other domains such as action selection (O’Shea et al, 2007), thus allowing task performance to recover (Sack and Linden, 2003; Siebner et al, 2009; Reithler et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Neuroanatomical substrates of action perception and understanding: an anatomic likelihood estimation meta-analysis of lesion-symptom mapping studies in brain injured patients

Urgesi

Candidi

Avenanti

2014

Front. Hum. Neurosci.

130

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Several neurophysiologic and neuroimaging studies suggested that motor and perceptual systems are tightly linked along a continuum rather than providing segregated mechanisms supporting different functions. Using correlational approaches, these studies demonstrated that action observation activates not only visual but also motor brain regions. On the other hand, brain stimulation and brain lesion evidence allows tackling the critical question of whether our action representations are necessary to perceive and understand others’ actions. In particular, recent neuropsychological studies have shown that patients with temporal, parietal, and frontal lesions exhibit a number of possible deficits in the visual perception and the understanding of others’ actions. The specific anatomical substrates of such neuropsychological deficits however, are still a matter of debate. Here we review the existing literature on this issue and perform an anatomic likelihood estimation meta-analysis of studies using lesion-symptom mapping methods on the causal relation between brain lesions and non-linguistic action perception and understanding deficits. The meta-analysis encompassed data from 361 patients tested in 11 studies and identified regions in the inferior frontal cortex, the inferior parietal cortex and the middle/superior temporal cortex, whose damage is consistently associated with poor performance in action perception and understanding tasks across studies. Interestingly, these areas correspond to the three nodes of the action observation network that are strongly activated in response to visual action perception in neuroimaging research and that have been targeted in previous brain stimulation studies. Thus, brain lesion mapping research provides converging causal evidence that premotor, parietal and temporal regions play a crucial role in action recognition and understanding.

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Pregenual or subgenual anterior cingulate cortex as potential effective region for brain stimulation of depression

et al. 2020

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Background:The dorsolateral prefrontal cortex (DLPFC) is the standard stimulation target for the repetitive transcranial magnetic stimulation (rTMS) treatment of major depression disorder (MDD). A retrospective study by Fox and colleagues found that a more negative resting-state functional magnetic resonance imaging (RS-fMRI) functional connectivity (FC) between left DLPFC and the subgenual anterior cingulate cortex (sgACC) in a large group of healthy participants is associated with a better curative effects of rTMS in MDD, suggesting that the sgACC may be an effective region.However, a recent meta-analysis on RS-fMRI studies found that the pregenual ACC (pgACC), rather than the sgACC, of MDD patients showed increased local activity. Methods: We used the stimulation coordinates in the left DLPFC analyzed by Fox et al. to perform RS-fMRI FC between the stimulation targets obtained from previous rTMS MDD studies and the potential effective regions (sgACC and pgACC, respectively) on the RS-fMRI data from 88 heathy participants. Results: (a) Both the pgACC and the sgACC were negatively connected to the left DLPFC; (b) both FCs of sgACC-DLPFC and pgACC-DLPFC were more negative in responders than in nonresponders; and (c) the associations between DLPFC-sgACC functional connectivity and clinical efficacy were clustered around the midline sgACC. Conclusions: Both the pgACC and the sgACC may be potential effective regions for rTMS on the left DLPFC for treatment of MDD. However, individualized ACC-DLPFC FC-based rTMS on depression should be performed in the future to test the pgACC or the sgACC as effective regions. K E Y W O R D S depression, functional connectivity, pregenual anterior cingulate cortex, repetitive transcranial magnetic stimulation, subgenual anterior cingulate cortex S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section. How to cite this article: Jing Y, Zhao N, Deng X-P, et al.Pregenual or subgenual anterior cingulate cortex as potential effective region for brain stimulation of depression. Brain

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Whole-Brain Haemodynamic After-Effects of 1-Hz Magnetic Stimulation of the Posterior Superior Temporal Cortex During Action Observation

Cited by 24 publications

References 60 publications

Bottom-Up and Top-Down Visuomotor Responses to Action Observation

Bottom-Up and Top-Down Visuomotor Responses to Action Observation

Neuroanatomical substrates of action perception and understanding: an anatomic likelihood estimation meta-analysis of lesion-symptom mapping studies in brain injured patients

Pregenual or subgenual anterior cingulate cortex as potential effective region for brain stimulation of depression

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