Whole-brain functional connectivity during script-driven aggression in borderline personality disorder

Ueltzhöffer, Kai; Herpertz, Sabine C.; Krauch, Marlene; Schmahl, Christian; Bertsch, Katja

doi:10.1016/j.pnpbp.2019.03.004

Cited by 23 publications

(12 citation statements)

References 40 publications

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“…Here, participants were instructed to vividly image brief stories describing neutral situations, anger-inducing interpersonal rejections, and subsequent acts of physical aggression against the provocateur. In the same study, female patients with BPD compared to healthy controls showed stronger increase in connectivity within a large brain network that suggested increased interaction of prefrontal cognitive control processes with thalamo-cortico-striatal action-selection processes while processing aggressive actions [66]. A stronger increase in connectivity between regions of the cognitive control network and regions of the motor system might be interpreted as the patients' attempts to control aggressive action impulses.…”

Section: Cognitive Controlmentioning

confidence: 82%

“…A stronger increase in connectivity between regions of the cognitive control network and regions of the motor system might be interpreted as the patients' attempts to control aggressive action impulses. These results may thus reflect a tendency to try and compensate ineffective emotion regulation strategies by directly suppressing aggressive action impulses [66].…”

Section: Cognitive Controlmentioning

confidence: 95%

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Understanding Brain Mechanisms of Reactive Aggression

Bertsch

Florange

Herpertz

2020

Curr Psychiatry Rep

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Purpose of Review To review the current literature on biobehavioral mechanisms involved in reactive aggression in a transdiagnostic approach. Recent Findings Aggressive reactions are closely related to activations in the brain’s threat circuitry. They occur in response to social threat that is experienced as inescapable, which, in turn, facilitates angry approach rather than fearful avoidance. Provocation-induced aggression is strongly associated with anger and deficits in cognitive control including emotion regulation and inhibitory control. Furthermore, the brain’s reward system plays a particular role in anger-related, tit-for-tat-like retaliatory aggression in response to frustration. More research is needed to further disentangle specific brain responses to social threat, provocation, and frustration. Summary A better understanding of the psychological and neurobiological mechanisms involved in reactive aggression may pave the way for specific mechanism-based treatments, involving biological or psychotherapeutic approaches or a combination of the two.

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Section: Cognitive Controlmentioning

confidence: 82%

Section: Cognitive Controlmentioning

confidence: 95%

Understanding Brain Mechanisms of Reactive Aggression

Bertsch

Florange

Herpertz

2020

Curr Psychiatry Rep

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“…Those findings demonstrated that the fusiform gyrus plays an important part in varying degrees of violence. The fusiform gyrus is part of the visual system, and has been proved to be involved in brain activity during anger-induced imagery tasks ( 39 ). Together with amygdala and other brain regions, the fusiform gyrus participates in processing affective visual stimuli in humans, contributing to the evaluation of which stimuli should be approached and which should be avoided ( 15 , 40 ).…”

Section: Discussionmentioning

confidence: 99%

Volumetric Abnormalities in Violent Schizophrenia Patients on the General Psychiatric Ward

Liu

Shao

et al. 2020

Front. Psychiatry

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Background: In recent years, neuroimaging has been used increasingly to explore the biological underpinnings of violence carried out by schizophrenia patients (SPs). Studies have focused mostly on patients with a history of carrying out severe physical assaults, or comorbid with substance abuse/personality disorder (SA/PD). As a result, participants were unrepresentative and the interpretation of brain-structure changes was confusing. Here, we concentrated on SPs on a general psychiatric ward with a history of relatively lower violence, and individuals comorbid with SA or PD were excluded. We expected to identify the characteristics of brain morphometry in this population, and to explore whether the morphometric changes were universal. Methods: Forty-eight violent schizophrenia patients (VSPs), twenty-seven non-VSPs (nVSPs) and 28 nonviolent healthy controls (HCs) were investigated. Voxel-based morphometry was used to evaluate the gray matter volume (GMV) of all study participants. Whole-brain analyses were used to reveal group effects and differences between any two groups. Correlation analyses were undertaken between significant brain regions and behavioral measurements in the VSP group.

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“…However, although many studies have investigated the brain structural and functional alterations in patients with BPD, these studies also report important findings regarding the pathological features of BPD. For example, some studies found that perturbed activity in the salience network and reward-related circuits also contribute to BPD [4,5]. Additionally, orbitofrontal overactivation in reward processing was found to be related to various symptoms (suicide, selfinjury, and cognitive and emotional distress) of BPD [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…For example, some studies found that perturbed activity in the salience network and reward-related circuits also contribute to BPD [4,5]. Additionally, orbitofrontal overactivation in reward processing was found to be related to various symptoms (suicide, selfinjury, and cognitive and emotional distress) of BPD [4][5][6]. Some studies also reported that the right caudate and left thalamus are key hubs of the abnormal functional network in the BPD patients compared to the healthy controls [7].…”

Section: Introductionmentioning

confidence: 99%

Common and distinct brain functional alterations in pharmacotherapy treatment-naïve female borderline personality disorder patients with and without auditory verbal hallucinations: a pilot study

Zhuo

Feng

Lin³

et al. 2020

Eur Arch Psychiatry Clin Neurosci

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Auditory verbal hallucinations (AVHs) are experienced by approximately 25% of patients with borderline personality disorder (BPD). Despite the high incidence, the pathological features of AVH in BPD remain unclear. This study aimed to investigate whole-brain functional connectivity (FC), as measured by functional connectivity density (FCD), and its relationship with AVH in BPD. 65 pharmacotherapy treatment-naïve female BPD patients (30 with AVH and 35 without AVH), and 35 female healthy controls were investigated. Functional magnetic resonance imaging (fMRI) data were collected to assess whole-brain FC and functional connectivity density mapping (FCDM) was applied to the fMRI data to compute FCD features. Compared to the healthy controls, both BPD groups (BPD-AVH and BPD without AVH) exhibited significantly higher gFCD values in the bilateral prefrontal lobe, bilateral orbital lobule, and bilateral insula, and significantly lower gFCD values in the SMA, right anterior temporal lobule, and the ACC. These altered regions were significantly associated with AVH in the BPD subjects. Moreover, higher gFCD values were observed in the left posterior temporal lobule and posterior frontal lobule. Aberrant alterations also emerged in the left posterior temporal lobule and posterior frontal lobule, mainly in Broca and Wernicke regions. Nevertheless, there was no significant correlation between gFCD values and the severity of AVH as measured by the AVH scores. In summary, we have identified aberrations in the FC and brain metabolism of the aforementioned neural circuits/networks, which may provide new insights into BPD-AVH and facilitate the development of therapeutic approaches for treating AVH in BPD patients.

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Whole-brain functional connectivity during script-driven aggression in borderline personality disorder

Cited by 23 publications

References 40 publications

Understanding Brain Mechanisms of Reactive Aggression

Understanding Brain Mechanisms of Reactive Aggression

Volumetric Abnormalities in Violent Schizophrenia Patients on the General Psychiatric Ward

Common and distinct brain functional alterations in pharmacotherapy treatment-naïve female borderline personality disorder patients with and without auditory verbal hallucinations: a pilot study

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