Whole-Body Vibration Promotes Skeletal Muscle Restructuring and Reduced Obesogenic Effect of MSG in Wistar Rats

Maciel, Jhyslayne Ignácia Hoff Nunes; Zazula, Matheus Felipe; Rodrigues, Diego Francis Saraiva; Boaro, Caroline De Toni; Boaretto, Mariana Laís; Andrade, Bárbara Zanardini de; Schneider, Sara Cristina Sagae; Naliwaiko, Katya; Torrejais, Márcia Miranda; Brancalhão, Rose Meire Costa; Ribeiro, Lucinéia de Fátima Chasko; Bertolini, Gladson Ricardo Flor

doi:10.1007/s12010-022-03923-7

Cited by 5 publications

(4 citation statements)

References 41 publications

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“…The MSG-obesity induction causes cytotoxic injury in hypothalamic nuclei that induces significant changes in the development of animals, mainly due to cell loss in the GH-secreting hypothalamic nuclei [28], as well described in the literature [7] and previously identified in works by our research group [9,21,29,30]. The relationship between reduced body growth and reduced muscle growth has also been extensively explored [1,22,28], with a consensus in the literature that MSG cytotoxicity still results in a model of short stature due to hormonal insufficiency that leads to low growth [22,31].…”

Section: Discussionmentioning

confidence: 63%

“…Similarly, in a swimming model, adiposity reduction and insulin secretion did not return to physiological patterns and changes in intestinal structure were still persistent [58]. In our research group, whole-body vibration training, despite promoting anti-obesogenic effects, was not able to completely repair the soleus muscles [29,59], extensor digitorum longus [30], tibialis anterior [21] and diaphragm [60] muscles. Furthermore, it did not restore the biochemical and structural parameters of the liver, adipose tissue and plasma to physiological levels [9].…”

Section: Discussionmentioning

confidence: 64%

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Early and Sustained Inflammatory State Induces Muscle Changes and Establishes Obesogenic Characteristics in Wistar Rats Exposed to MSG-Induced Obesity Model

Zazula¹,

Saraiva²,

Theodoro³

et al. 2022

Preprint

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The model of obesity induced by monosodium glutamate cytotoxicity on the hypothalamic nuclei is widely used in the literature. However, MSG promotes persistent muscle changes and there is a significant lack of studies that seek to elucidate the mechanisms by which damage refractory to reversal is established. This study aimed to investigate the early and chronic effects of MSG in-duction of obesity upon systemic and muscular parameters of Wistar rats. Animals were exposed to MSG subcutaneously (4 mg.g-1 b.w.) or saline (1.25 mg.g-1 b.w.) daily from PND01 to PND05 (n = 24). After, in PND15, 12 animals were euthanized to determine the plasma and inflammatory profile and to assess muscle damage. In PND142, the remaining animals were euthanized, and samples for histological and biochemical analyses were obtained. Our results suggest that early exposure to MSG reduced growth, and increased adiposity, induction hyperinsulinemia, and a pro-inflammatory scenario. In adulthood were found, peripheral insulin resistance, reduced muscle mass, oxidative capacity, neuromuscular junctions, increased fibrosis, and oxidative distress. Thus, we can conclude that the condition found in adult life and the difficulty in restoring the muscle profile are related to the metabolic damages established early.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 64%

Early and Sustained Inflammatory State Induces Muscle Changes and Establishes Obesogenic Characteristics in Wistar Rats Exposed to MSG-Induced Obesity Model

Zazula¹,

Saraiva²,

Theodoro³

et al. 2022

Preprint

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“…In addition to clinical studies, animal models have been used for basic research on chronic obesity [3][4][5]. For instance, the administration of monosodium glutamate (MSG) immediately after birth can be used to develop animal models of chronic obesity [6][7][8]. Since the hypothalamus is still immature immediately after birth, administered MSG crosses the blood-brain barrier (BBB) and flows into the hypothalamus, destroying nerve cells associated with satiety and the bioenergetic control center [9,10].…”

Section: Introductionmentioning

confidence: 99%

Combined Ingestion of Tea Catechin and Citrus β-Cryptoxanthin Improves Liver Function via Adipokines in Chronic Obesity

2023

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Recently, there has been an increase in the number of obese individuals, which has elevated the risk of related diseases. Although several studies have been performed to develop a definitive treatment for obesity, no solution has yet been achieved. Recent evidence suggests that tea catechins possess antiobesity effects; however, an impractical amount of catechin may be required to achieve antiobesity effects in humans. Moreover, studies are yet to elucidate the effects of the combined treatment of tea catechins with other substances. Here, we investigated the synergistic effects of catechins and β-cryptoxanthin in high-calorie diet-induced mice. Combined treatment with catechins and β-cryptoxanthin significantly suppressed obesity-induced weight gain and adipocyte size and area, restoring serum parameters to normal. Additionally, combined treatment with catechins and β-cryptoxanthin suppressed inflammatory responses in adipocytes, restored adiponectin levels to normal, protected the liver against obesity-induced damage, and restored normal liver function. Moreover, activin E level was restored to normal, possibly affecting the energy metabolism of brown adipocytes. Overall, these results suggest that the combined ingestion of tea catechins and β-cryptoxanthin was not only effective against obesity but may also help to prevent obesity-related diseases, such as diabetes and cardiovascular diseases.

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“…Studies suggest that whole-body vibration (WBV) can increase strength and power by activating muscle spindles through the tonic vibration reflex and promoting the synchronized recruitment of high-threshold motor units (9)(10)(11). However, the neuromuscular effects and practical applications of WBV in strength and power training are still under investigation, with controversial effects and potential risks of injury (12)(13)(14)(15)(16). The present study aims to investigate the effect of two WBV frequencies (30 and 45 Hz) on maximum isometric and resistance torques of the knee extensors, and power in two jumping modalities, Squat Jump (SJ) and Counter-Movement Jump (CMJ).…”

Section: Introductionmentioning

confidence: 99%

Long-Term Whole-Body Vibration on Knee Extensor Function: A Randomized Clinical Trial

Khun Schimanko,

Rossato,

Hidalgo

et al. 2023

Muscle Ligaments and Tendons J

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Introduction. The whole-body vibration platform (WBV) has shown positive effects on muscle aspects of strength and power due to the tonic vibration reflex. However, there is still disagreement about the parameters to be used. Objective. To investigate the effect of two WBV frequencies (30 and 45 Hz) on maximum isometric and resistance torques of the knee extensors, and power in two jumping modalities, Squat Jump (SJ) and Counter-Movement Jump (CMJ). Methods. Randomized clinical trial, composed of 40 healthy young adults of both sexes, aged between 18 and 30 years, not practicing systematic physical activities and randomized into three interventions according to the frequency of WBV: 30 Hz (F30), 45 Hz (F45) and sham (SG). The outcomes evaluated were the maximum isometric torque and quadriceps resistance measured by a traction dynamometer, and the quadriceps power obtained in two jumping modalities: squat and countermovement jump. The WBV intervention lasted 12 weeks, 2x weekly. After a familiarization session the outcomes were measured before and after the interventions. For statistical analysis the percentage of change between pre and post measures was used (Delta percentage). Results. No statistical differences were observed in the percentage deltas for any of the outcomes evaluated. Conclusions. WBV, regardless of the frequency adopted, did not influence the aspects of muscle function. Study registration. Registro Brasileiro de Ensaios Clínicos (ReBEC) with the number RBR-4rrn7cf.

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Whole-Body Vibration Promotes Skeletal Muscle Restructuring and Reduced Obesogenic Effect of MSG in Wistar Rats

Cited by 5 publications

References 41 publications

Early and Sustained Inflammatory State Induces Muscle Changes and Establishes Obesogenic Characteristics in Wistar Rats Exposed to MSG-Induced Obesity Model

Early and Sustained Inflammatory State Induces Muscle Changes and Establishes Obesogenic Characteristics in Wistar Rats Exposed to MSG-Induced Obesity Model

Combined Ingestion of Tea Catechin and Citrus β-Cryptoxanthin Improves Liver Function via Adipokines in Chronic Obesity

Long-Term Whole-Body Vibration on Knee Extensor Function: A Randomized Clinical Trial

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