Whole-Body Vibration Mimics the Metabolic Effects of Exercise in Male Leptin Receptor–Deficient Mice

McGee‐Lawrence, Meghan E.; Wenger, Karl; Misra, Sudipta; Davis, Catherine L.; Pollock, Norman K.; Elsalanty, Mohammed; Ding, Kai; Isales, Carlos M.; Hamrick, Mark W.; Wosiski‐Kuhn, Marlena; Arounleut, Phonepasong; Mattson, Mark P.; Cutler, Roy G.; Yu, Jack C.; Stranahan, Alexis M.

doi:10.1210/en.2016-1250

Cited by 36 publications

(23 citation statements)

References 69 publications

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“…Alternatively, RHFv showed mitigated hyperinsulinemia and increased expression of IRS1 in gonadal fat as compared to HF, indicating reduced insulin resistance. The effectiveness of 2×15 LIV, but not of 1×30 LIV, in improving glucose metabolism is in contrast to the previous study where one bout of 20-minute vibration/day shows improved glucose metabolism [ 39 ]. However, this previous study utilized young mice, reaffirming that the mechanosensitivity might indeed be age-dependent and that the inclusion of a refractory period in LMMS can boost the declined mechanosensitivity.…”

Section: Discussioncontrasting

confidence: 81%

Incorporating Refractory Period in Mechanical Stimulation Mitigates Obesity‐Induced Adipose Tissue Dysfunction in Adult Mice

Patel

Chan

Pagnotti

et al. 2017

Obesity

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ObjectiveTo determine whether inclusion of a refractory period between bouts of low magnitude mechanical stimulation (LMMS) can curb obesity-induced adipose tissue dysfunction and sequelae in adult mice.MethodsA diet-induced obesity model with 45kcal% fat diet was employed with intention-to-treat. C57BL/6J mice were weight-matched into four groups: low fat diet (LFD, n=8), high fat diet (HF, n=8), high fat diet with one bout of 30min LMMS (HFv, n=9), and high fat diet with two bouts of 15min LMMS with 5-hour separation (refractory period, RHFv, n=9). 2-week of diet was followed by 6-week of diet+LMMS.ResultsHF and HFv continued gaining body weight and visceral adiposity throughout the experiment, which was mitigated in RHFv. HF and HFv had increased adipocyte hypertrophy, immune cell infiltration (B-cells, T cells, and macrophages) into adipose tissue, adipose tissue inflammation (TNF-α gene expression), and decreased proportion of mesenchymal stem cells in adipose tissue, as compared to LFD, all of which was rescued in RHFv. Glucose intolerance, sequelae of adipose tissue dysfunction, were elevated in HF and HFv, but not in RHFv, as compared to LFD.ConclusionIncorporating a 5-hour refractory period between bouts of LMMS attenuates obesity-induced adipose tissue dysfunction and mitigates glucose intolerance.

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Section: Discussioncontrasting

confidence: 81%

Incorporating Refractory Period in Mechanical Stimulation Mitigates Obesity‐Induced Adipose Tissue Dysfunction in Adult Mice

Patel

Chan

Pagnotti

et al. 2017

Obesity

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“…Prolonged increased physical activity in DAT −/− and in less extent in DAT +/− rats can provoke different changes in metabolism by analogy with the way it was observed on the model of leptin‐deficient animals (McGee‐Lawrence et al. ).…”

Section: Discussionmentioning

confidence: 73%

Comparative analysis of the influence of a high-fat/high-carbohydrate diet on the level of anxiety and neuromotor and cognitive functions in Wistar and DAT-KO rats

et al. 2019

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We compared anxiety, neuromotor, and cognitive functions in mutant rats with different allelic variants of dopamine transporter DAT knockout receiving balanced or excess in fat and fructose diet. The experiments were performed in DAT −/− homozygotes, DAT +/− heterozygotes, and DAT +/+ wild type rats. The genotype of DAT ‐ KO rats was confirmed by restriction analysis of DAT gene compared to behavioral responses in the open field test ( OF ). Animals in the first groups of each strain were fed a balanced AIN 93M diet; and those in the second groups with a high‐fat/high‐fructose diet. Neuromotor function was studied as grip strength, and behavioral responses were assessed in the elevated plus maze and conditioned passive avoidance response tests. The mass of the internal organs and white and brown fat, as well as selected lipid and nitrogen metabolism parameters in blood plasma were determined at the end of the experiment. DAT −/− had the highest specific grip strength, and showed an increase in initial exploratory activity in comparison with DAT +/− and DAT +/+. The exploratory activity was significantly reduced in the second test compared to the first one in DAT −/− and DAT +/− of first but not second group. Anxiety decreased with age in the second groups of DAT +/− and DAT +/+ (but not in DAT −/−) and was higher in DAT +/+ than in DAT +/− and DAT −/−. Excess fat and fructose resulted in the deterioration of short‐term memory in DAT +/+. Lipidomic indices of blood plasma were less responsive to diet in DAT −/− and DAT −/+ in comparison to DAT +/+. The increased As AT /Al AT activity ratio in DAT −/− compared with those in DAT +/+ suggests the activation of catabolism activity in the mutants. The consumption of excess fat and fructose significantly modified the effects produced by DAT gene allelic variants presumably due to the influence on the processes of dopamine metabolism.

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“…Furthermore, extreme obesity is associated with impaired leptin signaling, which induced alterations in the subchondral bone without changing systemic inflammatory cytokine levels or OA incidence . Accordingly, leptin‐deficient (ob/ob) mice had reduced bone mass as well as altered bone microarchitecture (of note, axial and appendicular bones may be differentially affected) and consequently, modified bone biomechanical properties, with potential effect in bone fracture healing . Exogenous leptin administration can act through central nervous system or peripherally, inhibiting or enhancing bone formation, respectively.…”

Section: Leptinmentioning

confidence: 99%

Biomechanics, obesity, and osteoarthritis. The role of adipokines: When the levee breaks

Francisco

Pérez

Pino

et al. 2017

Journal Orthopaedic Research

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Osteoarthritis is a high-incidence painful and debilitating disease characterized by progressive degeneration of articular joints, which indicates a breakdown in joint homeostasis favoring catabolic processes. Biomechanical loading, associated with inflammatory and metabolic imbalances of joint, strongly contributes to the initiation and progression of the disease. Obesity is a primary risk factor for disease onset, and mechanical factors increased the risk for disease progression. Moreover, inflammatory mediators, in particular, adipose tissue-derived cytokines (better known as adipokines) play a critical role linking obesity and osteoarthritis. The present article summarizes the knowledge about the role of adipokines in cartilage and bone function, highlighting their contribution to the imbalance of joint homeostasis and, consequently, pathogenesis of osteoarthritis. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:594-604, 2018.

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Whole-Body Vibration Mimics the Metabolic Effects of Exercise in Male Leptin Receptor–Deficient Mice

Cited by 36 publications

References 69 publications

Incorporating Refractory Period in Mechanical Stimulation Mitigates Obesity‐Induced Adipose Tissue Dysfunction in Adult Mice

Incorporating Refractory Period in Mechanical Stimulation Mitigates Obesity‐Induced Adipose Tissue Dysfunction in Adult Mice

Comparative analysis of the influence of a high-fat/high-carbohydrate diet on the level of anxiety and neuromotor and cognitive functions in Wistar and DAT-KO rats

Biomechanics, obesity, and osteoarthritis. The role of adipokines: When the levee breaks

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