Whole body vibration exercise combined with an extract of Coriandrum sativum modify some biochemical/physiological parameters in rats

Abstract

The aim of the present study was to evaluate the effect of the association of whole body vibration (WBV) exercise with an aqueous extract of coriander on the biodistribution of the radiopharmaceutical sodium pertechnetate, on the concentration of some plasma biomarker, on the feed intake, on the body mass, and on the stool consistency in rats. Rats were divided in four groups and submitted to different treatments for 40 days. The control group (CON) received deionized water. The group treated with coriander (COR) received the extract of coriander. The rats that were exposed to WBV exercises (WBV-E) also received deionized water. A group of animals received coriander and was exposed to WBV (COR + WBV-E). We found in testis a decrease (0.13 ± 0.01 to 0.06 ± 0.03) of the percentages of injected radioactivity per gram (%ATI/g) in the WBV-E in comparison with the COR. There is no significant alteration on the concentrations of the plasma biomarkers. The feed intake showed a statistically significant increase in WBV-E. No significant difference on the body mass was found. The stool analysis showed a statistical difference on the consistency between COR (hard and dry, darker) and all the other groups (normal). In conclusion, it was verified that possible modifications in some biochemical/physiological parameters of the rats submitted to WBV exercise would be capable to increase the feed intake without changing the body mass, and normalizing the stool consistency altered by the coriander supplementation. Further studies are needed to try to understand better the biological effects involving the association of WBV exercise and coriander.

Effects of Coriandrum sativum L. in Association with Physical Exercise in Alloxan-Induced Type 1 Diabetes Mellitus in Rats

“…We did not find altered uptake (%ATI/g) of Na 99m TcO 4 in the studied organs, indicating that WBV and/or coriander were not capable of promoting changes in biochemical/physiological variables in organs of rats with T1DM. In a previous study using healthy rats [25], the results were similar to those observed here. Our data are also similar to those of Ogawa et al [31], who did not observe significant differences in the radiopharmaceutical 18 F-sodium fluoride uptake ratio in bone surrounding implants between rats subjected to WBV exercise and controls.…”

“…Experimental procedures were applied for 5 days/week for 4 weeks. The experimental variables used in this current study were similar to our previous study [25].…”

“…Rats were killed by CO 2 asphyxiation following the Conselho Nacional de Controle de Experimentação Animal (CONCEA) guideline and the organs (thyroid, stomach, bowel, kidney, liver, pancreas, bone, lung, heart, spleen, muscle and bladder) were harvested and radioactivity was determined in a well counter. Percentages of the injected radioactivity per gram (%ATI/g) in the organs were calculated as reported elsewhere [25].…”

“…Three different and independent evaluators daily analyzed the consistency of the stool and chose a value according to the scale. Values ranged from 1 to 4 as described [25] with Type 1 being hard, dry, and dark stool, Type 2 being normal with cracks in the surface, Type 3 being smooth and soft, and Type 4 being fluffy pieces with ragged edges (mushy stool). The median of these three analyses was considered.…”

“…The radiopharmaceutical sodium pertechnetate (Na99mTcO4) is widely used in experimental investigations [24]. In addition, physiological parameters as body mass, food intake and stool consistency help to understand which changes the concomitant intervention can provide in the long term [25]. The current study aimed to evaluate the effect of concomitant treatment of an aqueous extract of coriander and WBV exercise on physiological parameters, such as biodistribution of the radiopharmaceutical sodium pertechnetate (Na 99m TcO 4 ), concentration of specific plasma biomarkers, body mass, food intake, and stool consistency in Wistar rats with T1DM.…”