Whole body vibration accelerates the functional recovery of motor nerve components in sciatic nerve-crush injury model rats

Abstract

This study aimed to investigate the effect of whole body vibration (WBV) on the sensory and motor nerve components with sciatic nerve injury model rats. Surgery was performed on 21 female Wister rats (6–8 weeks) under intraperitoneal anesthesia. The nerve-crush injuries for the left sciatic nerve were inflicted using a Sugita aneurysm clip. The sciatic nerve model rats were randomly divided into two groups (n= 9; control group, n= 12; WBV group). The rats in the WBV group walked in the cage with a vibratory stimulus (frequency 50 Hz, 20 min/day, 5 times/wk), while those in the control group walked in the cage without any vibratory stimulus. We used heat stimulation-induced sensory threshold and lumbar magnetic stimulation-induced motor-evoked potentials (MEPs) to measure the sensory and motor nerve components, respectively. Further, morphological measurements, bilateral hind-limb dimension, bilateral gastrocnemius dimension, and weight were evaluated. Consequently, there were no significant differences in the sensory threshold at the injury side between the control and WBV groups. However, at 4 and 6 weeks postoperatively, MEPs latencies in the WBV group were significantly shorter than those in the control group. Furthermore, both sides of the hind-limb dimension at 6 weeks postoperatively, the left side of the gastrocnemius dimension, and both sides of the gastrocnemius weight significantly increased. In conclusion, WBV especially accelerates the functional recovery of motor nerve components in sciatic nerve-crush injury model rats.

Adenosine A2A Receptor Agonist, Polydeoxyribonucleotide Treatment Improves Locomotor Function and Thermal Hyperalgesia Following Neuropathic Pain in Rats

“…Surgical procedure was applied to cause crush injury in the SNI inducing groups [ 5 , 13 ]. Incising on the gluteal muscle was made following anesthesia by intraperitoneal application of Zoletil 50 (10 mg/kg; Vibac Laboratories, Carros, France), and then exposed right sciatic nerve.…”

“…Among various peripheral nerve injuries, SNI is one of the neuropathies that causes painful symptoms. The affected limbs exhibit abnormal gait, hyperalgesia, and edema, and these symptoms worsen due to acceleration of inflammatory activity [ 4 , 5 ]. Damage to peripheral nerves releases various substances involved in nociceptive signaling, such as proinflammatory cytokines, in the early stages [ 6 ].…”