Whole body turbo STIR MRI in unknown primary tumor detection

Eustace, Stephen; Tello, Richard; Decarvalho, Victor L.; Carey, John J.; Melhem, Elias R.; Yucel, E K

doi:10.1002/jmri.1880080336

Cited by 46 publications

(30 citation statements)

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“…Some investigators have discussed the utility of short inversion time inversion recovery (STIR) MR imaging for detection of lymph nodes with metastasis in various malignant cancers (16)(17)(18)(19)(20). In addition, it was reported that quantitative and qualitative analyses of STIR turbo-spin-echo(TSE) MR imaging enable differentiation of lymph nodes with metastasis from those without with sensitivity values that are greater than or equal to those of FDG-PET (20).…”

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confidence: 99%

Metastases in Mediastinal and Hilar Lymph Nodes in Patients With Non-Small Cell Lung Cancer

Nakayama¹,

Miyasaka²,

Omatsu³

et al. 2010

Journal of Computer Assisted Tomography

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Abstract:Objective: To evaluate DW MR imaging for detection of metastases in lymph nodes by using quantitative analysis.Methods: Seventy patients with NSCLC were examined with DW and STIR TSE MR imaging. ADC of each lung cancer and lymph node was calculated from DW MR imeges. Difference of the ADC in a lung cancer and a lymph node was calculated (D1). From STIR TSE MR images, ratios of signal intensity in a lymph node to that in a 0.9% saline phantom was calculated Results: Mean D1 in the lymph node group with metastases was lower than that in the group without metastases (P<.001). When an D1 of 0.24×10 -3 mm 2 /sec. was used as the positive-test threshold, sensitivity, specificity, and accuracy were 69.2%, 100%, and 94.0%, respectively on a per-patient basis. There was no significant difference (P>.05) between quantitative analyses of DW MR images and STIR MR images.Conclusion: Quantitative analysis of DW MR images enables differentiation 2 of lymph nodes with metastasis from those without.

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confidence: 99%

Metastases in Mediastinal and Hilar Lymph Nodes in Patients With Non-Small Cell Lung Cancer

Nakayama¹,

Miyasaka²,

Omatsu³

et al. 2010

Journal of Computer Assisted Tomography

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“…Results of several studies in adults have shown the usefulness of wholebody MR imaging in oncologic evaluation (8)(9)(10)(11)(12)(13)(14)(15). Results of several studies in children with a variety of tumors showed that whole-body MR imaging was superior to bone scintigraphy for allowing detection of skeletal metastases (16)(17)(18)(19)(20)(21)(22).…”

Section: Discussionmentioning

confidence: 99%

Whole-Body MR Imaging for Staging of Malignant Tumors in Pediatric Patients: Results of the American College of Radiology Imaging Network 6660 Trial

et al. 2013

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Purpose:To compare whole-body magnetic resonance (MR) imaging with conventional imaging for detection of distant metastases in pediatric patients with common malignant tumors. Materials and Methods:This institutional review board-approved, HIPAA-compliant, multicenter prospective cohort study included 188 patients (109 male, 79 female; mean age, 10.2 years; range, , 1 to 21 years) with newly diagnosed lymphoma, neuroblastoma, or soft-tissue sarcoma. Informed consent was obtained and all patients underwent noncontrast material-enhanced whole-body MR imaging and standardpractice conventional imaging. All images were reviewed centrally by 10 pairs of readers. An independent panel verified the presence or absence of distant metastases. Detection of metastasis with whole-body MR and conventional imaging was quantified by using the area under the receiver operating characteristic curve (AUC). The effects of tumor subtype, patient age, and distant skeletal and pulmonary disease on diagnostic accuracy were also analyzed. Results:Of the 134 eligible patients, 66 (33 positive and 33 negative for metastasis) were selected for image review and analysis. Whole-body MR imaging did not meet the noninferiority criterion for accuracy when compared with conventional imaging for detection of metastasis (difference between average AUCs was 20.03 [95% confidence interval: 20.10, 0.04]); however, the average AUC for solid tumors was significantly higher than that for lymphomas (P = .006). More skeletal metastases were detected by using whole-body MR imaging than by using conventional imaging (P = .03), but fewer lung metastases were detected (P , .001). Patient age did not affect accuracy. Conclusion:The noninferior accuracy for diagnosis of distant metastasis in patients with common pediatric tumors was not established for the use of whole-body MR imaging compared with conventional methods. However, improved accuracy was seen with whole-body MR imaging in patients with nonlymphomatous tumors.q RSNA, 2012 Supplemental material: http://radiology.rsna.org/lookup /suppl

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“…Recently, cardiac-and/or respiratory-triggered conventional or black-blood STIR turbo SE imaging has been recommended for detection of metastatic tumors and metastatic lymph nodes (Fujimoto et al 1995;Eustace et al 1998;Takenaka et al 2002;Ohno et al 2004dOhno et al , 2007cKawai et al 2006). These novel sequences may make to quantitatively assess the signal intensity of lymph nodes by means of comparison with a 0.9% normal saline phantom Ohno et al 2004dOhno et al , 2007c.…”

Section: Mr Assessment Of N Classificationmentioning

confidence: 99%

“…However, recent advances in MR techniques such as fast imaging and moving table techniques make it possible to perform wholebody MR imaging. Its usefulness has been investigated in the staging of breast cancer and the search for primary lesions in patients with metastatic carcinoma from an unknown primary lesion (Eustace et al 1998;Walker et al 2000;Antoch et al 2003;Lauenstein et al 2004;Takahara et al 2004;Goehde et al 2005;Schmidt et al 2006). It was concluded that whole-body MR imaging may constitute a single, cost-effective imaging test for patients with metastatic carcinoma from an unknown primary (Eustace et al 1998;Walker et al 2000;Antoch et al 2003;Lauenstein et al 2004;Takahara et al 2004;Goehde et al 2005;Schmidt et al 2006).…”

Section: Whole-body Mr Imaging For Assessment Of M Classification In mentioning

confidence: 99%

Lung Cancer

Ohno¹,

Koyama²,

Dinkel³

2016

MRI of the Lung

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Since the publication of the Radiologic Diagnostic Oncology Group Report (RDOG) in 1991, the clinical application of pulmonary magnetic resonance (MR) imaging to patients with lung cancer has been limited. MDCT has been much more widely available for staging of lung cancer in clinical situations. Traditionally, FDG-PET or PET/CT is the only modality that reveals biological glucose metabolism of lung cancer, and ventilation and/or perfusion scintigraphy is the only modality that demonstrates pulmonary function. However, recent advances of MR systems and utilization of contrast media make it possible to overcome the limitation of chest MR imaging. Therefore, in the last years, several investigators have demonstrated the significant comprehensive potential of MR imaging to substitute for MDCT and nuclear medicine examinations in lung cancer staging. Currently, MR imaging in lung cancer patients can be applied for (1) detection of pulmonary nodules, (2) characterization of solitary pulmonary nodules, and (3) assessment of TNM classification in routine clinical practice. We believe that further basic studies, as well as clinical applications of newer MR techniques, will play an important role in the future management of patients with lung cancer including MRI.

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Whole body turbo STIR MRI in unknown primary tumor detection

Cited by 46 publications

References 11 publications

Metastases in Mediastinal and Hilar Lymph Nodes in Patients With Non-Small Cell Lung Cancer

Metastases in Mediastinal and Hilar Lymph Nodes in Patients With Non-Small Cell Lung Cancer

Whole-Body MR Imaging for Staging of Malignant Tumors in Pediatric Patients: Results of the American College of Radiology Imaging Network 6660 Trial

Lung Cancer

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