Whole-body short-chain fatty acid (SCFA) production rates and plasma concentrations are not associated with health characteristics in human adults

Kirschner, Sarah; Deutz, N.E.P.; Simbo, S; Park, J.K.; Engelen, M.P.

doi:10.1016/j.clnesp.2020.09.280

Cited by 1 publication

(2 citation statements)

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“…SCFA production was based on plasma concentrations, which is influenced by intestinal absorption and first‐pass metabolism. Stable‐isotope approaches are able to measure whole‐body SCFA production rate more precisely and thus better estimate bacterial SCFA production 46 …”

Section: Discussionmentioning

confidence: 99%

“…SCFA production was based on plasma concentrations, which is influenced by intestinal absorption and first-pass metabolism. Stable-isotope approaches are able to measure whole-body SCFA production rate more precisely and thus better estimate bacterial SCFA production 46. CONCLUSIONSIntestinal dysfunction is present in predominantly obese, clinically stable CHF patients and associated with reduced muscle quality, emotional distress, and impaired cognitive function.…”

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confidence: 99%

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Impaired intestinal function is associated with lower muscle and cognitive health and well‐being in patients with congestive heart failure

Kirschner¹,

Deutz²,

Rijnaarts³

et al. 2021

J Parenter Enteral Nutr

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Background Small‐ and large‐intestinal perturbations have been described as prevalent extracardiac systemic manifestations in congestive heart failure (CHF), but alterations in protein digestion and absorption and plasma short‐chain fatty acid (SCFA) concentrations and the potential link with other systemic effects (muscle and cognitive health) have not been investigated in CHF. Methods We analyzed protein digestion and absorption with dual stable tracer method in 14 clinically stable, noncachectic CHF outpatients (mean left ventricular ejection fraction: 35.5% [95% CI, 30.9%–40.1%]) and 15 controls. Small‐intestinal non–carrier‐mediated permeability and active carrier‐mediated glucose transport were quantified by sugar permeability test. Plasma SCFA (acetate, propionate, butyrate, isovalerate, valerate) concentrations were measured as intestinal microbial metabolites. Muscle function was assessed by isokinetic dynamometry, cognition by a battery of tests, and well‐being by questionnaire. Results Protein digestion and absorption were impaired by 29.2% (P = .001) and active glucose transport by 38.4% (P = .010) in CHF. Non–carrier‐mediated permeability was not altered. Whereas plasma propionate, butyrate, and isovalerate concentrations were lower in CHF (P < .05), acetate and valerate concentrations did not differ. Overall, intestinal dysfunction was associated with impaired leg muscle quality, emotional distress, and cognitive dysfunction (P < .05). Conclusions We identified impaired protein digestion and absorption and altered SCFA concentrations as additional intestinal dysfunctions in CHF that are linked to reduced muscle and cognitive health and well‐being. More research is needed to implement strategies to improve intestinal function in CHF and to investigate the mechanisms underlying its link with other systemic manifestations.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%