Whole-Body Scintigraphy With Radioiodine-131 A Comprehensive List of False-Positives With Some Examples

Ir, McDougall

doi:10.1097/00003072-199510000-00002

Cited by 112 publications

(50 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Interestingly, by using real-time quantitative RT-PCR, we showed that NIS transcription level in these tissues is about tenfold lower than that in normal thyroid tissue. This significant NIS expression is in accordance with the active efflux of iodide towards external secretion as observed on total body scanning with radioactive iodine (3,9). In contrast to a recent immunohistochemical report (17), NIS mRNAs were found to be more abundant in submandibular than in parotid glands.…”

Section: Discussionsupporting

confidence: 86%

“…Iodide also accumulates in various tissues including the salivary glands, lacrymal glands, gastric mucosa, mammary gland, ovaries, placenta, choroid plexus and thymus (9). Using immunohistochemical methods, we and others have demonstrated that NIS protein is detectable in several extra-thyroidal tissues that are known to accumulate iodide, mainly salivary glands and gastric mucosa (10±14).…”

Section: Introductionmentioning

confidence: 94%

See 1 more Smart Citation

Na(+)/I(-) symporter and Pendred syndrome gene and protein expressions in human extra-thyroidal tissues

Lacroix¹,

Mian²,

Caillou

et al. 2001

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: The expression of two recently identified iodide transporters, namely the sodium/iodide symporter (NIS) and pendrin, the product of the gene responsible for the Pendred syndrome (PDS), was studied in a series of various extra-thyroidal human tissues, and especially in those known to concentrate iodide. Methods: To this end, we used real-time kinetic quantitative PCR to detect NIS and PDS transcripts and immunohistochemistry for the analysis of their protein products. Results: NIS gene and protein expression was detected in most tissues known to concentrate iodine, and particularly in salivary glands and stomach. In contrast, PDS gene expression was restricted to a few tissues, such as kidney and Sertoli cells. Interestingly, in kidney, pendrin immunostaining was detected at the apical pole of epithelial cells of the thick ascending limb of the Henle's loop and of the distal convoluted tubule. Conclusion: This study provides new insights on the localization and expression of two genes involved in iodide transport and emphasizes the interest of combining real-time quantitative PCR and immunohistochemistry for the comparison of gene and protein expression in tissues.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 94%

Na(+)/I(-) symporter and Pendred syndrome gene and protein expressions in human extra-thyroidal tissues

Lacroix¹,

Mian²,

Caillou

et al. 2001

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Planar 131 I scintigraphy is known to be associated with a substantial number of equivocal results, or even false positives (8). In recent years, it has been shown that the analysis of SPECT-CT images helps to precisely localize focal iodine uptake and to characterize it as either normal or abnormal.…”

Section: Discussionmentioning

confidence: 99%

Postablation 131I scintigraphy with neck and thorax SPECT–CT and stimulated serum thyroglobulin level predict the outcome of patients with differentiated thyroid cancer

Ciappuccini

Heutte

Trzepla

et al. 2011

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Neck and thorax single photon emission computed tomography with computed tomography (SPECT-CT) improves the reliability of postablation 131 I whole-body scan (WBS) for differentiated thyroid cancer (DTC). The aim of this study was to assess the prognostic value for persistent or recurrent disease of postablation 131 I scintigraphy combining WBS and neck and thorax SPECT-CT with that of the previously known predictive factors. Methods: This is a single referral center prospective study with a median follow-up of 29 months. Postablation 131 I WBS and neck and thorax SPECT-CT were performed in 170 consecutive patients treated between 2006 and 2008. Stimulated serum thyroglobulin (Tg) and anti-thyroglobulin antibodies (TgAb) levels were measured. The impact on disease-free survival of age; gender; postablation 131 I scintigraphy; stimulated serum Tg level; T, N, and M status; and macroscopic lymph node involvement was assessed by univariate and multivariate analyses. Results: Persistent or recurrent disease was observed in 32 (19%) patients. In the whole group of patients, only positive WBS with SPECT-CT was related to an increased risk of persistent or recurrent disease (hazards ratio (HR)Z65.21, 95% confidence interval (CI)Z26.03-163.39, P!0.0001). In patients without TgAb (nZ146), both positive WBS with SPECT-CT (HRZ18.86, 95% CIZ5.02-70.85, P!0.0001) and serum Tg level R58 ng/ml (HRZ4.42, 95% CIZ1.18-16.53, PZ0.0271) were associated with an increased risk. Conclusion: In patients with DTC, the cross analysis of postablation 131 I scintigraphy with neck and thorax SPECT-CT and stimulated serum Tg level enables early assessment of the risk of persistent or recurrent disease.European Journal of Endocrinology 164 961-969

show abstract

“…However, DTC renal metastasis presenting as a primary renal tumor has been reported by Graham & Roe (1995) and Ruggiero et al (2005). Therefore, intense 131 I uptake in the abdomen by 131 I-WBS should not be assumed to simply be physiological gastrointestinal tract uptake or a false-positive finding (Langsteger et al 1993, McDougall 1995, Brucker-Davis et al 1996; the suspicion of a renal metastasis should be raised and effectively excluded.…”

Section: Renal Metastasismentioning

confidence: 97%

Rare metastases of differentiated thyroid carcinoma: pictorial review

Song

Xue²,

Xu³

et al. 2011

Endocrine-Related Cancer

127

148

View full text Add to dashboard Cite

Differentiated thyroid cancer (DTC) is usually indolent with good prognosis and long-term survival. However, DTC distant metastasis is often a grave event and accounts for most of its diseasespecific mortality. The major sites of distant metastases are the lung and bone. Metastases to the brain, breast, liver, kidney, muscle, and skin are rare or relatively rare. Nevertheless, recognizing rare metastases from DTC has a significant impact on the clinical decision making and prognosis of patients.131 I single photon emission computed tomography/computed tomography ( 131 I-SPECT/CT) can provide both metabolic and anatomic information about a lesion; therefore, it can better localize and define the 131 I-WBS findings in DTC patients. In this pictorial review, the imaging features of a range of rare metastases from DTC are demonstrated, with a particular emphasis on the 131 I-SPECT/CT diagnostic aspect.

show abstract

Whole-Body Scintigraphy With Radioiodine-131 A Comprehensive List of False-Positives With Some Examples

Cited by 112 publications

References 0 publications

Na(+)/I(-) symporter and Pendred syndrome gene and protein expressions in human extra-thyroidal tissues

Na(+)/I(-) symporter and Pendred syndrome gene and protein expressions in human extra-thyroidal tissues

Postablation 131I scintigraphy with neck and thorax SPECT–CT and stimulated serum thyroglobulin level predict the outcome of patients with differentiated thyroid cancer

Rare metastases of differentiated thyroid carcinoma: pictorial review

Contact Info

Product

Resources

About