Whole Body Retention in Rats of Different 191 Pt Compounds Following Inhalation Exposure

Abstract

The whole body retention, excretion, lung clearance, distribution, and concentration of l9lPt in other tissues was determined in rats following a single inhalation exposure to different chemical forms of 19iPt. The chemical forms of 19iPt used in study were 191PtCI4, 191Pt(SO4)2, '9iPtO, and 19iPt metal. Immediately after exposure most of the 191Pt was found in the gastrointestinal and respiratory tract. Movement of the i9iPt through the gastrointestinal tract was rapid, most of the i9iPt being eliminated within 24 hr after exposure. Lung clearance was much slower, with a clearance half-time of about 8 days. In addition to the lungs, kidney and bone contained the highest concentrations of i9iPt.

Platinum‐Group Metals

“…However, Pt 2+ was described to bind approximately 30 and 10 7 times more firmly than Cd and Zn, respectively (Zhang et al 1997). Inhalational application of different Pt species [PtCl 4 , Pt(SO 4 ) 2 , PtO, metallic Pt] revealed no differences with regard to Pt retention in different rat tissues (Moore et al 1975). Thus, provided that Pt is taken up by an organism, its accumulation is independent of the Pt species offered.…”

“…However, solitary Pd reactions occurred with a low frequency, whereas Tab. 20.9: Selected data on the toxicity of PGM compounds (data from Moore et al 1975;IPCS 1991;Marquardt and Schäfer 1994 mostly combined reactions with other metals, primarily nickel, have been observed. There are also indications for a potential allergenicity of Rh (Bedello et al 1987; de la Cuadra and Grau Massanes 1991), but to date only a few case studies have been reported (Gebel 2000).…”

Platinum group elements in the environment and their health risk

“…Platinum and its compounds were mainly retained in the respiratory tract (lungs, Trachea); moreover, significant concentrations were also determined in the kidneys and femur. The whole body retention after 24 hours depended on the applied Pt species, and decreased according to the queue (PtCl 4 > Pt(SO 4 ) 2 > PtO 2 > Pt) (Moore et al, 1975b; see also Artelt et al, 1999b).…”

Environmental Fate of Traffic-Derived Platinum Group Metals

“…The ability to assimilate PGE [salts (Pt (IV) and Rh (III)] by fish was assessed with the application of European eel (Anguilla anguilla). Elevated platinum and rhodium concentration in tissues where normally heavy metals accumulate was observed; these tissues are liver, intestines, kidneys, and gills (120,133,134). Furthermore, it was stated that European eels are able to accumulate palladium present in road dust.…”

“…After several months of exposure, platinum and palladium were detected in many organs, mainly kidneys, livers, spleen, suprarenal glands, lungs and bones. After oral application of PtCl 4 and PdCl 2 , the bioavailable fraction of these metals constituted approximately 1% of the total applied dose (120,133,134). The accumulation of car catalysts' derived platinum was also studied in tissues of female rats of Lewis-type by applying model solutions with molecules similar to those emitted by car catalysts.…”