Whole-body protein breakdown and 3-methylhistidine excretion during brief fasting, starvation, and intravenous repletion in man

Lowry, S F; Horowitz, Glenn D.; Jeevanandam, Malayappa

doi:10.1097/00005373-198604000-00019

Cited by 8 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, muscle protein was catabolized when the nutritional requirements were not met. Nutrition-dependent changes in muscle protein metabolism have been reported previously (Lowry et al, 1985;Yoshizawa et al, 1997;Garlick et al, 1998). The metabolic effects associated with the PN1 parenteral nutrition (isotonic glucose) were extremely severe.…”

Section: Discussionmentioning

confidence: 86%

Nutritional modulation of protein metabolism after gastrointestinal surgery

et al. 2007

View full text Add to dashboard Cite

Background: The metabolic response to surgery includes alterations in protein metabolism, resulting in a net loss of proteins. Protein hypercatabolism is considered an unavoidable consequence of injury, and an important source of morbidity and mortality. Our purpose was to determine the effect of nutrition on protein metabolism following gastrointestinal surgery, and to elucidate whether postoperative protein loss can be prevented with adequate nutritional support. Methods: Patients who had undergone gastrointestinal surgery were given four different parenteral nutritions with increasing glucose, lipid and amino acid content during the 7 days following surgery. Nitrogen balance, protein synthesis and protein breakdown were determined using in vivo stable isotope labelling. Other metabolites (3-methylhistidine, creatinine, urea, cortisol, glucose, insulin, amino acids and C-reactive protein) were measured. Results: A nutrition-dependent alteration of protein metabolism was found in response to surgical injury. Nutrition modified nitrogen balance, whole-body protein breakdown and, to a lesser extent, whole-body protein synthesis and muscle protein breakdown. The low-energy parenteral nutrition without amino acids produced a negative nitrogen balance (postoperative day 7 ¼ À0.381 g protein kg À1 day À1 ) and important alterations in postoperative protein metabolism that did not normalize during the study period (day 7 protein synthesis ¼ 239% and protein breakdown 217% vs preoperative). Patients receiving the two low energy parenteral nutritions containing amino acids had a less negative nitrogen balance (day 7 ¼ À0.011 and À0.133 g protein kg À1 day À1 ) and a transient increase in protein metabolism. The complete parenteral nutrition maintained, during all studied days, protein metabolism parameters within the preoperative reference range (synthesis day 2 ¼ 92%, day 4 ¼ 110% day 7 ¼ 79%; breakdown day 2 ¼ 85%, day 4 ¼ 80%, day 7 ¼ 76% vs preoperative) and a positive nitrogen balance (day 2 ¼ þ 0.0387, day 4 ¼ þ 0.578 and day 7 ¼ þ 0.227 g protein kg À1 day À1 ). Conclusion: Complete nutritional support can prevent protein loss after gastrointestinal surgery and maintain protein metabolism without alterations.

show abstract

Section: Discussionmentioning

confidence: 86%

Nutritional modulation of protein metabolism after gastrointestinal surgery

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Consequently, it was measured using blood samples in this study. Skeletal muscle is the main source of degraded protein after surgery, and the 3-MH level is considered to be a reliable indicator of the skeletal muscle protein breakdown rate [24,25]. However, according to recent reports, muscle protein breakdown begins after the first 24 h post-surgery, and the protein donor during the early response to surgery should mainly be of intestinal origin (smooth muscle) rather than skeletal muscle [26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Effect of intraoperative acetated Ringer’s solution with 1% glucose on glucose and protein metabolism

et al. 2010

View full text Add to dashboard Cite

show abstract

“…This might be one reason why no correlation was found between urinary excretion and extremity flux of 3-MH during the early postoperative pe riod in a recent study [28]. When no trauma was involved, but other factors known to influence protein metabolism were studied, e.g., starvation and intravenous feeding, changes in urinary 3-MH excretion corre lated to changes in extremity amino acid flux [21] and whole body protein breakdown [20]. The fact that no surgical trauma was in volved in the experimental model used to induce hyperthyroidism in rats supports the interpretation of the present results that in creased 3-MH excretion may reflect en hanced protein degradation in skeletal mus cle.…”

Section: Discussionmentioning

confidence: 99%

Effects of Beta-Blocking Agents on Urinary Excretion of 3-Methylhistidine during Experimental Hyperthyroidism in Rats

Angerås¹,

Jagenburg²,

Lindstedt³

et al. 1987

Eur Surg Res

View full text Add to dashboard Cite

Beta-blocking agents are increasingly used as preoperative treatment of hyper-thyroid patients. Relatively little is known about the effects of these drugs on metabolic alterations in hyperthyroidism. The aim of this investigation was to study the effects of two different beta-blocking agents on the urinary excretion of 3-methylhistidine (3-MH) during experimental hyperthyroidism in rats. Experimental hyperthyroidism was induced by daily intraperitoneal injections of triiodothyronine (T₃; 100 µg/l00 g body weight) for 3 days. Control animals were injected with corresponding volumes of solvent. Groups of rats received food enriched with metoprolol (8.8 mmol/kg of diet) or propranolol (3.3 mmol/kg of diet) or food without additions. Urinary 3-MH excretion was increased by about 40% during experimental hyperthyroidism. A similar increase of 3-MH excretion was found in animals receiving T₃ + metoprolol, whereas the excretion of 3-MH was reduced to control level in hyper-thyroid rats receiving propranolol. No effects of metoprolol or propranolol on 3-MH excretion were found in control animals. Although the source of 3-MH cannot be exactly defined, the present results indicate that increased proteolysis in skeletal muscle and/or other tissues during experimental hyperthyroidism was reduced by propranolol.

show abstract

Whole-body protein breakdown and 3-methylhistidine excretion during brief fasting, starvation, and intravenous repletion in man

Cited by 8 publications

References 0 publications

Nutritional modulation of protein metabolism after gastrointestinal surgery

Nutritional modulation of protein metabolism after gastrointestinal surgery

Effect of intraoperative acetated Ringer’s solution with 1% glucose on glucose and protein metabolism

Effects of Beta-Blocking Agents on Urinary Excretion of 3-Methylhistidine during Experimental Hyperthyroidism in Rats

Contact Info

Product

Resources

About