Whole-body positron emission tomography: normal variations, pitfalls, and technical considerations.

Gordon, B A; Flanagan, Fidelma; Dehdashti, Farrokh

doi:10.2214/ajr.169.6.9393189

Cited by 135 publications

(60 citation statements)

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“…It is known that individual differences can also be present within study subjects (Engel et al 1996;Gordon et al, 1997;Ramos et al 2001;Tan and Ong 2004).…”

Section: Discussionmentioning

confidence: 99%

Standardised uptake values of 2-deoxy-2-[<sup>18</sup>F]fluoro-d-glucose using PET/CT in normal cats

Cho¹,

Lee²

2013

Vet. Med. - Czech

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ABSTRACT:In this study we assessed the normal physiological and dynamic thoracoabdominal distribution of 18 F fluorodeoxyglucose ( 18 F-FDG) uptake and the standardized uptake values (SUVs) of the major parenchymal organs in five normal young adult domestic short haired cats. Dynamic PET data were acquired with a transaxial field-of-view (FOV) PET/CT scanner, Regions of interests (ROIs) were manually drawn over the left ventricular free wall, left ventricular blood pool, liver, spleen, and left and right renal cortices. The SUVs of these organs were calculated for 5-min frames over the 90 min acquisition. The uptake of 18 F-FDG within the major organs, showed a tendency to gradually decline, except for the left ventricle and blood pool. The decrease in SUV was rapid after injection with a plateau occurring after 30 minutes. The uptake of 18 F -FDG within the hepatic parenchyma was low compared to that in the kidney at the beginning of study. A steady decline in the hepatic parenchyma SUV was quite similar to that observed for the kidneys .The SUV of 18 F-FDG within the spleen was low. Uptake of 18 F-FDG within the myocardium was minimal. These SUV data from the parenchymal organs of normal cats compares favourably with those of normal humans and dogs and can be used in feline studies using PET/CT for the evaluation of various diseases. Furthermore, PET/CT can provide higher quality images over shorter examination times than conventional PET.

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“…It is known that individual differences can also be present within study subjects (Engel et al 1996;Gordon et al, 1997;Ramos et al 2001;Tan and Ong 2004).…”

Section: Discussionmentioning

confidence: 99%

Standardised uptake values of 2-deoxy-2-[<sup>18</sup>F]fluoro-d-glucose using PET/CT in normal cats

Cho¹,

Lee²

2013

Vet. Med. - Czech

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“…PET findings were assessed according to the criteria, which we defined, due to lack of established criteria. The main difficulty in FDG-PET diagnosis of stomach cancer is physiological uptake in the stomach (Cook et al, 1996;Gordon et al, 1997;Shreve et al, 1999;Koga et al, 2003), but there was no cancer subject in whom we had difficulty in differentiating physiological uptake from cancer lesions. Nevertheless, it is possible that there were tiny cancers overlooked due to significant FDG background uptake.…”

Section: Discussionmentioning

confidence: 99%

“…Because there are no established criteria for assessing FDG-PET findings, we determined the following criteria based on previous reports (Cook et al, 1996;Gordon et al, 1997;Shreve et al, 1999;Koga et al, 2003): (1) positive pattern 1 -spotty or focal accumulation that was stronger than the uptake in the liver ( Figure 1A); positive pattern 2 -any accumulation in the area of the lower stomach ( Figure 1B). This category was based on a report by Koga et al (2003), suggesting that physiological gastric FDG uptake is significantly higher at the oral end than the anal end, and that a stronger gastric FDG uptake at the anal end might therefore be suggestive of a pathological uptake.…”

Section: Assessment Of Fdg-pet Findingsmentioning

confidence: 99%

Evaluation of 18F-2-deoxy-2-fluoro-glucose positron emission tomography for gastric cancer screening in asymptomatic individuals undergoing endoscopy

Shoda¹,

Kakugawa²,

Saito

et al. 2007

Br J Cancer

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18 F-2-deoxy-2-fluoro-glucose Positron Emission Tomography (FDG-PET) has been recently proposed as a promising cancerscreening test. However, the validity of FDG-PET in cancer screening has not been evaluated. We investigated the sensitivity of FDG-PET compared with upper gastric endoscopy in gastric cancer screening for asymptomatic individuals. A total of 2861 consecutive subjects (1600 men and 1261 women) who were asymptomatic and who underwent both FDG-PET and upper gastrointestinal endoscopy between 1 February 2004 and 31 January 2005 were included in this study. Both endoscopists and a radiologist were unaware of the results of the other diagnostic tests. The FDG-PET images were examined using criteria determined by the pattern of FDG accumulation. Sensitivity and specificity of FDG-PET were calculated compared with endoscopic diagnosis as the gold standard. Among 2861 subjects enrolled in the study, there were 20 subjects with gastric cancer, of whom 18 were T1 in depth of cancer invasion. Positive FDG-PET results were obtained only in 2 of the 20 cancer subjects. The calculated sensitivity and specificity for overall gastric cancers were 10.0% (95% confidence interval (CI): 1.2 -31.7%) and 99.2% (95% CI: 98.8 -99.5%), respectively. 18 F-2-deoxy-2-fluoro-glucose Positron Emission Tomography was poorly sensitive for detection of gastric cancer in the early stages.

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“…검사 환자의 0.6-3.3% 정도로 보고되었으며 [8]- [11] 자가 면역 갑상선 질환(autoimmune thyroid disease)과 관련 있음을 보고하였다 [12]- [15] .…”

Section: F-fdg 갑상선 섭취 증가는 Pet/ctunclassified

Clinical Correlation between the Autoimmune Thyroid Disease for the Thyroid Autoimmune Antibodies and the Maximum Standardized Uptake Value: Base on the Hashimoto's Thyroiditis and the Graves' Disease

Woo¹,

Baek²,

Yoo³

et al. 2014

Journal of the Korean Society of Radiology

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The purpose of this study were to analyze the clinical correlation between the thyroid autoimmune antibodies (anti-TPO Ab, anti-TG Ab, and TSH) and the maximum standardized uptake value (SUV max ) base on the Hashimoto's thyroiditis and the Graves' disease in diffusely 18 F-FDG uptake of the thyroid gland to the PET/CT image. To achieve this, we was performed the PET/CT examination for the 1,097 subjects from May 2010 to April 2013 in the health screening, and was detected the diffused FDG thyroid uptake, and was additionally performed the thyroid function test (TFT) and the ultrasound (US). As a results, the autoimmune thyroid disease with the diffused FDG thyroid uptake were discovered 39 patients (3.9%), of this, the Hashimoto's thyroiditis was 43.6% and the Graves' disease was 23.1%. Hashimoto's thyroiditis was shown the positive reaction of high titer between the anti-TPO Ab and the anti-TG Ab level, and the correlation coefficient between the SUV max and the anti-TPO Ab was a statistically significant (r>04, p<0.05). Also, Graves' disease was shown the positive reaction of high titer most of the thyroid autoimmune antibodies, and the correlation coefficient between the SUV max and the anti-TPO Ab was a statistically significant (r>05, p<0.01). Therefor, when have a high standard of the SUV max due to the diffusely 18 F-FDG uptake of the thyroid gland, Hashimoto's thyroiditis and Graves' disease were proportionally increased the anti-TPO Ab and TSH level, respectively. The correlation coefficient between the SUV max and the thyroid autoimmune antibodies will be the most influential criterion that was a standard of judgment for the epihpenomenon of the autoimmune thyroid disease, and it will be available for the clinical application.

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Whole-body positron emission tomography: normal variations, pitfalls, and technical considerations.

Cited by 135 publications

References 1 publication

Standardised uptake values of 2-deoxy-2-[<sup>18</sup>F]fluoro-d-glucose using PET/CT in normal cats

Standardised uptake values of 2-deoxy-2-[<sup>18</sup>F]fluoro-d-glucose using PET/CT in normal cats

Evaluation of 18F-2-deoxy-2-fluoro-glucose positron emission tomography for gastric cancer screening in asymptomatic individuals undergoing endoscopy

Clinical Correlation between the Autoimmune Thyroid Disease for the Thyroid Autoimmune Antibodies and the Maximum Standardized Uptake Value: Base on the Hashimoto's Thyroiditis and the Graves' Disease

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