Whole-body MRI for initial staging of paediatric lymphoma: prospective comparison to an FDG-PET/CT-based reference standard

Littooij, Annemieke S.; Kwee, Thomas C.; Barber, Ignasi; Granata, Claudio; Vermoolen, Malou A.; Enríquez, Goya; Zsíros, József; Soh, Shui Yen; Keizer, Bart de; Beek, F. J. A.; Hobbelink, Monique G.G.; Bierings, Marc; Stoker, Jaap; Nievelstein, Rutger A.J.

doi:10.1007/s00330-014-3114-0

Cited by 95 publications

(80 citation statements)

References 33 publications

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“…Diffusion-weighted MR imaging is sensitive for detecting lymph node involvement, represented by bright round-to-ovoid lesions larger than 10 mm in size with restricted diffusion (Fig 19c) (117). Whole-body diffusion-weighted imaging has been shown in preliminary studies to be feasible and comparable to FDG PET/CT for initial staging (117).…”

Section: Sporadic Burkitt Lymphomamentioning

confidence: 98%

Solid Tumors of the Peritoneum, Omentum, and Mesentery in Children: Radiologic-Pathologic Correlation:From the Radiologic Pathology Archives

Em¹,

Dm²,

Am³

et al. 2015

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Intraperitoneal solid tumors are far less common in children than in adults, and the histologic spectrum of neoplasms of the peritoneum and its specialized folds in young patients differs from that in older patients. Localized masses may be caused by inflammatory myofibroblastic tumor, Castleman disease, mesenteric fibromatosis, or other mesenchymal masses. Inflammatory myofibroblastic tumor is a mesenchymal tumor of borderline biologic potential that appears as a solitary circumscribed mass, possibly with central calcification. Castleman disease is an idiopathic lymphoproliferative disorder that appears as a circumscribed, intensely enhancing mass in the mesentery. Mesenteric fibromatosis, or intra-abdominal desmoid tumor, is a benign tumor of mesenchymal origin associated with familial adenomatous polyposis. Mesenteric fibromatosis appears as a mildly enhancing, circumscribed solitary mass without metastases. Diffuse peritoneal disease may be due to desmoplastic small round cell tumor (DSRCT), non-Hodgkin lymphoma, or rhabdomyosarcoma. DSRCT is a rare member of the small round blue cell tumor family that causes diffuse peritoneal masses without a visible primary tumor. A dominant mass is typically found in the retrovesical space. Burkitt lymphoma is a pediatric tumor that manifests with extensive disease because of its short doubling time. The bowel and adjacent mesentery are commonly involved. Rhabdomyosarcoma may arise as a primary tumor of the omentum or may spread from a primary tumor in the bladder, prostate, or scrotum. Knowledge of this spectrum of disease allows the radiologist to provide an appropriate differential diagnosis and suggest proper patient management.

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Section: Sporadic Burkitt Lymphomamentioning

confidence: 98%

Solid Tumors of the Peritoneum, Omentum, and Mesentery in Children: Radiologic-Pathologic Correlation:From the Radiologic Pathology Archives

Em¹,

Dm²,

Am³

et al. 2015

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“…The emerging role of whole-body magnetic resonance imaging for disease monitoring in NHL Over the last years, several studies have demonstrated the good reliability of whole-body magnetic resonance imaging (WB-MRI) for lymphoma staging, mainly using 18 F-FDG-PET/CT as the reference standard [24][25][26][27]. WB-MRI enables avoiding radiation exposure and intravenous contrast agent administration, allowing the evaluation of all potential lymphomatous sites through morphological and functional sequences ( Figs.…”

Section: Imaging Monitoring and Wwmentioning

confidence: 99%

Whole body magnetic resonance in indolent lymphomas under watchful waiting: The time is now

et al. 2017

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The indolent non-Hodgkin lymphomas (i-NHLs) are characterised by 'indolent' clinical behaviour with slow growth and prolonged natural history. The watchful waiting (WW) strategy is a frequently employed treatment option in these patients. This implies a strict monitoring by imaging examinations, including 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) and CT. A major concern is radiation exposure due to regularly monitoring by conventional imaging procedures. Several studies have demonstrated the reliability of whole-body magnetic resonance imaging (WB-MRI) for lymphoma staging. WB-MRI could be useful for active surveillance in iNHLs providing the suspect of disease progression that can be then confirmed by additional diagnostic procedures, including 18F-FDG-PET/CT. The directive 2013/59 by the European Union claims that if a radiation-free imaging technique allows obtaining the same diagnostic results, it should be invariably used.In this setting, WB-MRI may be considered a reasonable option in i-NHLs under WW, replacing imaging modalities that cause exposure to ionising radiations. This will help to reduce the cancer risk in i-NHL patients for whom chemo-/radiotherapy remain the usual treatment options following the usually long WW phase. The scientific community should raise the awareness of the risk of ionising radiations in i-NHLs and the emphasise the need for establishing the proper place of WB-MRI in lymphoma imaging. Key Points• Watchful waiting is a reasonable option in patients with indolent non-Hodgkin lymphomas.• Imaging is crucial to monitor patients with indolent nonHodgkin lymphomas.• CT and 18 F-FDG-PET/CT are commonly used, implying a substantial radiation exposure.• WB-MRI is highly reliable in lymphoma staging.• WB-MRI may be considered to monitor indolent nonHodgkin lymphomas under watchful waiting.

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“…30 Interestingly, some studies pointed out that DWI may lead to clinically relevant overstaging. [31][32][33] Quarles van Ufford et al 32 concluded that large-scale studies are needed to prove that DWI leads to correct staging compared with PET/CT.…”

Section: Pet/ct and Pet/mr For Initial Stagingmentioning

confidence: 97%

PET/CT, MR, and PET/MR in Lymphoma and Melanoma

Schwenzer

Pfannenberg

2015

Seminars in Nuclear Medicine

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Whole-body MRI for initial staging of paediatric lymphoma: prospective comparison to an FDG-PET/CT-based reference standard

Cited by 95 publications

References 33 publications

Solid Tumors of the Peritoneum, Omentum, and Mesentery in Children: Radiologic-Pathologic Correlation:From the Radiologic Pathology Archives

Solid Tumors of the Peritoneum, Omentum, and Mesentery in Children: Radiologic-Pathologic Correlation:From the Radiologic Pathology Archives

Whole body magnetic resonance in indolent lymphomas under watchful waiting: The time is now

PET/CT, MR, and PET/MR in Lymphoma and Melanoma

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