Whole-body MRI: detecting bone metastases from prostate cancer

Nakanishi, Katsuyuki; Tanaka, Junichiro; Nakaya, Y.; Maeda, Nobuji; Sakamoto, Atsuhiko; Nakayama, Akiko; Satomura, Hiroki; Sakai, Mio; Koyama, Koji; Yamamoto, Yoshiyuki; Nagahara, Akira; Nishimura, Kazuo; Takenaka, Satoshi; Tomiyama, Noriyuki

doi:10.1007/s11604-021-01205-6

Cited by 26 publications

(15 citation statements)

References 87 publications

(143 reference statements)

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“…Nakanishi et al [23] who studied the role of WB-DWIBS in diagnosis of bony metastasis form prostatic cancer, he asserted that WB-MRI was the most reliable technique for detecting prostate cancer bony metastasis. It offered the benefit of detecting lesions that were missed by traditional imaging modalities like CT and BS.…”

Section: Discussionmentioning

confidence: 99%

Suppression of background body signals in whole-body diffusion-weighted imaging for detection of bony metastases: a pilot study

Eltonbary

Elmashad

Khodair

et al. 2023

Egypt J Radiol Nucl Med

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Background Whole-body diffusion-weighted magnetic resonance is being developed as a tool for assessing tumor spread. Patients with known primary tumors require meticulous evaluation to assess metastasis for better staging; we attempted to detect bony metastasis without radiation exposure. Our study's goal was to use whole-body diffusion-weighted imaging with background body signal suppression (WB-DWBIS) to evaluate bony metastasis in confirmed patients who have primary tumors. Results Our study included 90 patients with known primary cancer, 10 patients were excluded as they had no bony metastasis, from 80 patients: 36 (45.0%) having one site of metastasis, 36 (45%) having two sites of metastasis, and 8 (10.0%) having three sites of metastasis. 56 (70.0%) of the metastasis sites were bony metastasis, and 76 were mixed both bony and non-bony, including 32(40.0%) lung, 16 (20.0%) liver, and 28 (35%) lymph nodes. Sensitivity of bone scanning in detecting metastasis was as follows: 95.1% sensitivity and 92.0% accuracy, while that of whole-body diffusion-weighted image with background signals suppression was 94.8% sensitivity and 91.7% accuracy, WB-DWBIS inter-observer agreement in the detection of bony metastatic deposits in cancer patients was good (0.7 45, agreement = 93.2%). Conclusions Using WB-DWBIS images, bone lesion identification and characterization (site and number) were improved, producing outcomes similar to bone scanning without the use of ionizing radiation.

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Section: Discussionmentioning

confidence: 99%

Suppression of background body signals in whole-body diffusion-weighted imaging for detection of bony metastases: a pilot study

Eltonbary

Elmashad

Khodair

et al. 2023

Egypt J Radiol Nucl Med

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“…Our study also supports their conclusions. Consequently, the ADC is calculated and has been adopted for evaluating multiple and large lesions ( 13 ). MRI-based ADC and T2WI scans showed good performance in malignant prostate lesions and predicting extracapsular extension and positive surgical margins ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

“…In particular, the ADC may act as a useful differential definition by delivering reliable information for the GS of suspected prostate cancer ( 10 ). The ADC has also been shown to be helpful for classifying and identifying lesions as well as evaluating disease activity ( 13 , 14 ).…”

Section: Introductionmentioning

confidence: 99%

Ki67 and the apparent diffusion coefficient in postoperative prostate cancer with endocrine therapy

Che

et al. 2023

Front. Surg.

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BackgroundProstate-specific antigen (PSA) is a critical part of prostate cancer (PCa) screening, diagnosis, staging, and prognosis. However, elevated PSA levels can also be caused by several external factors. To improve the specificity and sensitivity of PSA in clinical practice, we explored whether markers or parameters may be used as prognostic targets for PCa by long-term follow-up.MethodsA total of 121 PCa patients who underwent laparoscopic radical prostatectomy (LRP) were included in our study, all of whom underwent imaging and preoperative pathological diagnosis. Endocrine therapy has long been applied to treat postoperative patients. The prognosis of enrolled patients was followed, and statistics were collected. Spearman's correlation analysis was applied to examine the relationship and clinical parameters. Kaplan–Meier analysis was used to process the clinical variables of PCa patients. Cox proportional hazards regression analysis was applied to examine univariate and multivariate variables.ResultsThe Gleason score (GS), PSA, clinical stage, nerve infiltration, organ confinement, Ki67 and apparent diffusion coefficient (ADC) were significantly associated with prognosis (all P < 0.05). The GS, PSA, clinical stage, organ confined, Ki67, nerve infiltration and ADC were included in the multivariate analysis (all P < 0.05). Ultimately, Ki67 and the ADC were found to provide meaningful predictive information (both P < 0.05).ConclusionsKi67 and the ADC may be clinically and analytically valid prognostic biomarkers and imaging parameters in PCa. They may be useful for predicting the prognosis and risk of PCa patients undergoing postoperative routine endocrine therapy.

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“…DWIBS reflects the motion restriction of water molecules in areas of high cell density and is another tool for detecting metastasis [ 23 ]. The main advantage of DWIBS is that it is less invasive, as there is no exposure to radiation and images can be acquired without the use of contrast media [ 24 ]. However, lesions in bones with high signal intensity on T2-weighted images, such as hemangiomas or red bone marrow in patients with anemia, can be judged as abnormal signals.…”

Section: Patient Selectionmentioning

confidence: 99%

Stereotactic body radiotherapy for spinal oligometastases: a review on patient selection and the optimal methodology

2022

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Stereotactic body radiotherapy (SBRT) has excellent local control and low toxicity for spinal metastases and is widely performed for spinal oligometastases. However, its additional survival benefit to standard of care, including systemic therapy, is unknown because the results of large-scale randomized controlled trials regarding SBRT for oligometastases have not been reported. Consequently, the optimal patient population among those with spinal oligometastases and the optimal methodology for spine SBRT remain unclear. The present review article discusses two topics: evidence-based optimal patient selection and methodology. The following have been reported to be good prognostic factors: young age, good performance status, slow-growing disease with a long disease-free interval, minimal disease burden, and mild fluorodeoxyglucose accumulation in positron emission tomography. In addition, we proposed four measures as the optimal SBRT method for achieving excellent local control: (i) required target delineation; (ii) recommended dose fraction schedule (20 or 24 Gy in a single fraction for spinal oligometastases and 35 Gy in five fractions for lesions located near the spinal cord); (iii) optimizing dose distribution for the target; (iv) dose constraint options for the spinal cord.

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Whole-body MRI: detecting bone metastases from prostate cancer

Cited by 26 publications

References 87 publications

Suppression of background body signals in whole-body diffusion-weighted imaging for detection of bony metastases: a pilot study

Suppression of background body signals in whole-body diffusion-weighted imaging for detection of bony metastases: a pilot study

Ki67 and the apparent diffusion coefficient in postoperative prostate cancer with endocrine therapy

Stereotactic body radiotherapy for spinal oligometastases: a review on patient selection and the optimal methodology

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