Whole-Body-MR-Diffusion Weighted Imaging in Oncology

Wilhelm, Thomas; Stieltjes, Bram

doi:10.1055/s-0033-1335428

Cited by 28 publications

(22 citation statements)

References 43 publications

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“…In a current article, Demehri et al observed that when DCE-MRI was used to examine 9 MPNST and 22 nerve sheath tumors, 50 % of the MPNST exhibited an early arterial contrast medium enhancement, which, however, was discovered in only 11 % of the benign peripheral nerve sheath tumors [35]. To put it simply, diffusion-weighted imaging is based on the limited diffusion (random thermal motion of water molecules) owing to the high cell density in tumors [36]. For characterizing soft tissue lesions, the anatomical localization and observation of ADC values -in addition to the signal intensity in DWI -are critical [36].…”

Section: Role Of Various Imaging Modalities For Neurofibromatosis Typmentioning

confidence: 99%

“…To put it simply, diffusion-weighted imaging is based on the limited diffusion (random thermal motion of water molecules) owing to the high cell density in tumors [36]. For characterizing soft tissue lesions, the anatomical localization and observation of ADC values -in addition to the signal intensity in DWI -are critical [36]. In a study involving 31 histologically confirmed nerve sheath tumors, the minimal, yet not the median, ADC values were significantly lower in MPNST than in benign nerve sheath tumors.…”

Section: Role Of Various Imaging Modalities For Neurofibromatosis Typmentioning

confidence: 99%

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Multimodal Imaging in Neurofibromatosis Type 1-associated Nerve Sheath Tumors

Salamon

Mautner

Adam

et al. 2015

Fortschr Röntgenstr

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Neurofibromatosis type 1 (NF1) is a neurogenetic disorder. Individuals with NF1 may develop a variety of benign and malignant tumors of which peripheral nerve sheath tumors represent the most frequent entity. Plexiform neurofibromas may demonstrate a locally destructive growth pattern, may cause severe symptoms and may undergo malignant transformation into malignant peripheral nerve sheath tumors (MPNSTs). Whole-body magnetic resonance imaging (MRI) represents the reference standard for detection of soft tissue tumors in NF1. It allows for identification of individuals with plexiform neurofibromas, for assessment of local tumor extent, and for evaluation of whole-body tumor burden on T2-weighted imaging. Multiparametric MRI may provide a comprehensive characterization of different tissue properties of peripheral nerve sheath tumors, and may identify parameters associated with malignant transformation. Due to the absence of any radiation exposure, whole-body MRI may be used for serial?follow-up of individuals with plexiform neurofibromas. 18F-fluorodeoxyglucose positron-emission-tomography (FDG PET/CT) allows a highly sensitive and specific detection of MPNST, and should be used in case of potential malignant transformation of a peripheral nerve sheath tumor. PET/CT provides a sensitive whole-body tumor staging. The use of contrast-enhanced CT for diagnosis of peripheral nerve sheath tumors is limited to special indications. To obtain the most precise readings, optimized examination protocols and dedicated radiologists and nuclear medicine physicians familiar with the complex and variable morphologies of peripheral nerve sheath tumors are required. Key points: ??Individuals with NF1 may develop benign and malignant nerve sheath tumors. ??Whole-body MRI is the reference standard to identify nerve sheath tumors in NF1. ??MRI provides a comprehensive characterization of the growth pattern, growth dynamics and extent of nerve sheath tumors. ??18F-FDG PET/CT provides a sensitivity of 100?% and a specificity of 77???95?% for detection of malignant transformation. Citation Format: ??Salamon J, Mautner VF, Adam G et?al. Multimodal Imaging in Neurofibromatosis Type 1-associated Nerve Sheath Tumors. Fortschr R?ntgenstr 2015; 187: 1084???1092

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Section: Role Of Various Imaging Modalities For Neurofibromatosis Typmentioning

confidence: 99%

Section: Role Of Various Imaging Modalities For Neurofibromatosis Typmentioning

confidence: 99%

Multimodal Imaging in Neurofibromatosis Type 1-associated Nerve Sheath Tumors

Salamon

Mautner

Adam

et al. 2015

Fortschr Röntgenstr

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“…Whole-body diffusion-weighted (WB-DWI) MRI was conducted according to the method described by Wilhelm et al [29]. In order to evaluate bone metastases, patients were separately classified into one of the following categories by two senior musculoskeletal radiologists and two senior nuclear medicine fellows: (1) benign or normal and (2) diffuse or metastatic focal based on previously reported criteria [30].…”

Section: Whole-body Mrimentioning

confidence: 99%

Detection of Prostate Cancer Metastasis by Whole Body Magnetic Resonance Imaging Combined with Bone Scintigraphy and PSA Levels

Ning²,

Li³

et al. 2016

Cell Physiol Biochem

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Background/Aims: The combined role of whole-body magnetic resonance imaging (WB-MRI), bone scintigraphy and prostate specific antigen (PSA) were considered in predicting metastases and prognosis of prostate cancer (PCa). Methods: Totally 38 PCa patients underwent WB-MRI, bone scintigraphy and PSA detections, and 34 benign prostate hyperplasia (BPH) patients were checked with PSA. Pearson correlations were performed to determine associations among PSA, apparent diffusion coefficient (ADC) and Gleason scoring. Specificity and sensitivity were for comparison of diagnostic accuracies. Patients' baseline PSA, PSA nadir and time to the prostate-specific antigen nadir (TTPN) were analyzed, and Kaplan-Meier survival curves were also established. Results: ADC values were negatively correlated with PSA levels (r_s = -0.389, P = 0.016) and Gleason scores (r_s = -0.432, P = 0.006), while PSA levels were positively correlated with Gleason scoring (r_s = 0.493, P = 0.002). Diagnostic efficacy of whole body-diffusion weighted imaging (WB-DWI) combined with PSA seemed the most favorable, and bone scintigraphy was advantageous in identifying bone metastasis. PSA levels (> 61.60 µg/L), Gleason scores (> 6) and ADC (< 0.81 × 10^-3 mm²/s) could all predict pessimistic prognosis (HR = 7.65; HR = 6.09; HR = 7.28). Smaller PSA nadir (≤ 1.0 µg/L) and longer TTPN (> 3 months) were associated with increased 5-year survival rate (P < 0.05). Conclusions: The combined efficacies of WB-MRI, bone scintigraphy and PSA levels were desired in identifying PCa lesions and prognosis.

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“…In the meantime, this technique has also been used for full body diagnostics, in particular to answer oncological clinical requests [32,33]. Diffusion weighted imaging (DWI) essentially takes advantage of the limited diffusion (random thermal motion of the water molecules / Brownian molecular motion) caused by, for example, damaged membranes in infarcted areas.…”

Section: Diffusion-weighted Imagingmentioning

confidence: 99%

Magnetic Resonance Imaging of the Bowel: Today and Tomorrow

Kinner

Hahnemann

Forsting

et al. 2015

Fortschr Röntgenstr

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Magnetic resonance imaging of the small bowel has been feasible for more than 15 years. This review is meant to give an overview of typical techniques, sequences and indications. Furthermore, newly evaluated promising techniques are presented, which have an impact on the advance of MR imaging of the small and large bowel. Key Points: ??T2-weighted sequences both with and without fat saturation and T1-weighted fat saturated sequences prior to and following intravenous injection of a gadolinium-based contrast medium contitute the basics for bowel MR imaging. ??Newer MR applications, such as diffusion-weighted imaging or contrast-enhaced dynamic sequences supply addtional information; they should thus be integrated in a regular sequence protocol f?r bowel MRI. ??Additional new modalities like motility imaging and PET/MRI have to be evaluated in future studies. Citation Format: ??Kinner S, Hahnemann ML, Forsting M et?al. Magnetic Resonance Imaging of the Bowel: Today and Tomorrow. Fortschr R?ntgenstr 2015; 187: 160???167

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Whole-Body-MR-Diffusion Weighted Imaging in Oncology

Cited by 28 publications

References 43 publications

Multimodal Imaging in Neurofibromatosis Type 1-associated Nerve Sheath Tumors

Multimodal Imaging in Neurofibromatosis Type 1-associated Nerve Sheath Tumors

Detection of Prostate Cancer Metastasis by Whole Body Magnetic Resonance Imaging Combined with Bone Scintigraphy and PSA Levels

Magnetic Resonance Imaging of the Bowel: Today and Tomorrow

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