Whole-Body Magnetic Resonance Imaging in the Oncology Setting: An Overview and Update on Recent Advances

Bezerra, Régis Otaviano França; Recchimuzzi, Débora Zachello; Mota, Micaela Maciel dos Santos; García, Mora; Menezes, Marcos Roberto de; Mazo, Paulo E; Cerri, Giovanni Guido

doi:10.1097/rct.0000000000000772

Cited by 6 publications

(9 citation statements)

References 61 publications

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“…Susceptibility artefacts represent another challenge that may degrade image quality and mask lesions, leading to false negative results [11]. False positive results may be obtained due to the so-called "T2-shine through" effect, where lesions with high T2 signal may be mistaken for areas of restricted diffusion [1][2][3][4].…”

Section: Discussionmentioning

confidence: 99%

“…Early detection of metastasis in cancer patients is an essential step for timely management and a positive outcome. Osseous metastasis can be spinal or appendicular and extra-osseous metastasis can involve the liver, lung, and lymph nodes [1][2][3][4]. Different imaging modalities are used for the detection of osseous and extra-osseous metastasis.…”

Section: Introductionmentioning

confidence: 99%

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Whole-body diffusion-weighted imaging with background body signal suppression in the detection of osseous and extra-osseous metastases

et al. 2019

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Purpose: To assess the reproducibility of detection of osseous and extra-osseous metastases in cancer patients using whole-body diffusion-weighted imaging with background body signal suppression (WB-DWIBS). Material and methods: A prospective study was conducted on 39 consecutive patients (21 females, 18 males; mean age 48 years) with metastases, who underwent WB-DWIBS on a 1.5-T MR scanner. Image analysis was performed independently by two blinded observers. Inter-observer agreement was assessed for the detection of osseous (spinal, appendicular) and extra-osseous (hepatic, pulmonary, nodal, and peritoneal) metastases. Results: The overall inter-observer agreement of WB-DWIBS in the detection of osseous and extra-osseous metastases was excellent (k = 0.887, agreement = 94.44%, p = 0.001). There was excellent inter-observer agreement of both observers for the detection of osseous spinal (k = 0.846, agreement = 92.3%), osseous appendicular (k = 0.898, agreement = 94.8 %), hepatic (k = 0.847, agreement = 92.3%), pulmonary (k = 0.938, agreement = 97.4%), nodal metastases (k = 0.856, agreement = 94.9%), and peritoneal metastasis (k = 0.772, agreement = 94.9%). Conclusion: We concluded that WB-DWIBS is reproducible for detection of osseous and extra-osseous metastases in cancer patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Whole-body diffusion-weighted imaging with background body signal suppression in the detection of osseous and extra-osseous metastases

et al. 2019

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“…Whole-body protocols have evolved since they were first used 2 decades ago. Now it combines optimal anatomical information from 2 anatomical sequences: T1-weighted and short time inversion recovery (STIR), while functional qualitative and quantitative data, including DWI with ADC measurement, provide useful information from multiple regions of the body [ 7 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…Many studies have demonstrated the feasibility and reliability of whole-body CT and MRI, especially with diffusion-weighted imaging (DWI), as an alternative tool for staging of lymphoma, determination of tumour burden, prognostic biomarker, and assessment of treatment response [4][5][6][7]. Quantitative assessment of lymphoma was carried out in previous studies using apparent diffusion coefficient (ADC) measurement.…”

Section: Introductionmentioning

confidence: 99%

Whole-body diffusion-weighted imaging with background body signal suppression and quantitative apparent diffusion coefficient in the detection, staging, and grading of non-Hodgkin lymphoma

Razek¹,

Tawfik²,

Rahman³

et al. 2023

Pol J Radiol

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Purpose Assess reproducibility of detection, staging, and grading of non-Hodgkin lymphoma (NHL) using whole-body diffusion-weighted imaging with background body signal suppression (WB-DWIBS). Material and methods Thirty NHL patients underwent WB-DWIBS, divided into 2 groups according to staging and grading. Image analysis and apparent diffusion coefficient (ADC) measurement of the largest lymph node in each group were performed by 2 observers. Inter-observer agreement was performed. Results Overall inter-observer agreement for detection of NHL was excellent (k = 0.843; 92.05%) with excellent inter-observer agreement of nodal disease (cervical, thoracic and abdominal) (k = 0.783, 0.769, and 0.856; 96.67%, 90.0%, and 93.3% respectively), extra-nodal disease (k = 1; 100%), and splenic involvement (k = 0.67; 83.3%). The overall inter-observer agreement of DWIBS in staging of NHL was excellent (k = 0.90; 94.9%) with excellent inter-observer agreement for stage I (k = 0.93; 96.4%), stage II (k = 0.90; 94.8%), stage III (k = 0.89; 94.6%), and stage IV (k = 0.88; 94.0%). There was significant difference between ADC in stage I, II (0.77 ± 0.13, 0.85 ± 0.09 × 10 -3 mm 2 /s), and stage III, IV (0.63 ± 0.08, 0.64 ± 0.11 × 10 -3 mm 2 /s, p < 0.002, < 0.001). Interclass correlation showed almost perfect agreement for ADC measurement in staging and grading groups ( r = 0.96 and r = 0.85, respectively, p < 0.001). There was significant difference between ADC in aggressive lymphoma (0.65 ± 0.1, 0.67 ± 0.13 × 10 -3 mm 2 /s) and indolent lymphoma (0.76 ± 0.14, 0.84 ± 0.09 × 10 -3 mm 2 /s, p < 0.028, < 0.001). Conclusion DWIBS is reproducible for detection and staging of nodal and extra-nodal involvement in patients with NHL. ADC can quantitatively participate in the staging and grading of NHL.

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“…Early detection of metastasis in cancer patients is an essential step for timely management and a positive outcome. Extra-osseous metastasis can affect the liver, lung, and lymph nodes, while osseous metastasis can be spinal or appendicular [2][3][4][5]. Different imaging modalities are used for the detection of osseous and extra-osseous metastasis.…”

Section: Introductionmentioning

confidence: 99%

Suppression of background body signals in whole-body diffusion-weighted imaging for detection of bony metastases: a pilot study

Eltonbary

Elmashad

Khodair

et al. 2023

Egypt J Radiol Nucl Med

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Background Whole-body diffusion-weighted magnetic resonance is being developed as a tool for assessing tumor spread. Patients with known primary tumors require meticulous evaluation to assess metastasis for better staging; we attempted to detect bony metastasis without radiation exposure. Our study's goal was to use whole-body diffusion-weighted imaging with background body signal suppression (WB-DWBIS) to evaluate bony metastasis in confirmed patients who have primary tumors. Results Our study included 90 patients with known primary cancer, 10 patients were excluded as they had no bony metastasis, from 80 patients: 36 (45.0%) having one site of metastasis, 36 (45%) having two sites of metastasis, and 8 (10.0%) having three sites of metastasis. 56 (70.0%) of the metastasis sites were bony metastasis, and 76 were mixed both bony and non-bony, including 32(40.0%) lung, 16 (20.0%) liver, and 28 (35%) lymph nodes. Sensitivity of bone scanning in detecting metastasis was as follows: 95.1% sensitivity and 92.0% accuracy, while that of whole-body diffusion-weighted image with background signals suppression was 94.8% sensitivity and 91.7% accuracy, WB-DWBIS inter-observer agreement in the detection of bony metastatic deposits in cancer patients was good (0.7 45, agreement = 93.2%). Conclusions Using WB-DWBIS images, bone lesion identification and characterization (site and number) were improved, producing outcomes similar to bone scanning without the use of ionizing radiation.

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Whole-Body Magnetic Resonance Imaging in the Oncology Setting: An Overview and Update on Recent Advances

Cited by 6 publications

References 61 publications

Whole-body diffusion-weighted imaging with background body signal suppression in the detection of osseous and extra-osseous metastases

Whole-body diffusion-weighted imaging with background body signal suppression in the detection of osseous and extra-osseous metastases

Whole-body diffusion-weighted imaging with background body signal suppression and quantitative apparent diffusion coefficient in the detection, staging, and grading of non-Hodgkin lymphoma

Suppression of background body signals in whole-body diffusion-weighted imaging for detection of bony metastases: a pilot study

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