Whole Body Irradiation on the Healing of Fresh Fractures

Spittler, August W.; Batch, Joseph W.; Rutledge, Ben A.

doi:10.1001/archsurg.1954.01260050095013

Cited by 12 publications

(4 citation statements)

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“…However, by 16 weeks, both control and irradiated femurs reached more advanced stages of healing and were approaching normal torsional stiffness. These results are consistent with a previous study (12) that demonstrated microscopically that single doses of irradiation ranging from 300 to 900 rad resulted in a delay in healing that was greatest during the first 3 weeks. Thereafter, although the development was retarded and irregular, it was progressive.…”

Section: Discussionsupporting

confidence: 93%

The effect of radiation on the fracture repair process. A biomechanical evaluation of a closed fracture in a rat model

Markbreiter

Pelker

Friedlaender

et al. 1989

Journal Orthopaedic Research

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The effects of a single dose of irradiation on the biomechanical parameters of the fracture healing process were studied in a rat model. Intramedullary pinning was performed before production of a closed femoral midshaft fracture. The experimental group was exposed to 900 rad 3 days after fracture and was compared with a control group with a similar fracture that received no irradiation. Animals were killed at intervals ranging from 2-16 weeks after surgery and the bones were tested until failure in torsion. In the irradiated groups, a delay of 4 weeks was noted in the biomechanical parameters associated with fracture healing (torque to failure, torsional stiffness, angle to failure, and biomechanical stage). Despite this delay in the normal temporal progression, the staging and stiffness approached normal controls within an 8-week period. However, the torque to failure remained below normal levels at the conclusion of this study. These results differ from a previous study using an open fracture model.

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Section: Discussionsupporting

confidence: 93%

The effect of radiation on the fracture repair process. A biomechanical evaluation of a closed fracture in a rat model

Markbreiter

Pelker

Friedlaender

et al. 1989

Journal Orthopaedic Research

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“…Shelby, Taylor, Garnes, and Prigot (1958) used "viokase," a preparation of whole pancreatic extract, with similar success on 125 patients. Spittler and Parmenter (1954) reported their general impression of the use of a mixture of streptokinase and streptodornase on sloughing war wounds, and were also greatly impressed by the rapidity of slough clearance with these agents. " Debricin " was used by Douglas, Ferriday, and Gaughran (1958) in an experimental study on removal of necrotic tissue in guinea-pigs subjected to a standardized type of bum and found it greatly superior to five other enzyme preparations of similar nature.…”

Section: Resultsmentioning

confidence: 99%

"Debricin": A New Agent for Wound Debridement

Rob¹,

Singer²

1959

BMJ

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“…Dans nos conditions expérimentales, nous l'évaluons à 8 jours. Les travaux de Spittler chez le rat [19] ont montré que ce retard est proportionnel à la dose reçue. On peut signaler d'autre part les conclusions de H.Q.…”

Section: Discussionunclassified