Whole body hyperthermia treatment increases interleukin 10 and toll-like receptor 4 expression in patients with ankylosing spondylitis: A pilot study

Zauner, Dorothea; Quehenberger, Franz; Hermann, Josef; Dejaco, Christian; Stradner, Martin; Stojaković, Tatjana; Angerer, Hannes; Rinner, Beate; Graninger, Winfried

doi:10.3109/02656736.2014.956810

Cited by 15 publications

(10 citation statements)

References 30 publications

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“…When microorganisms infiltrate physical barriers such as skin and mucous membranes, TLRs bind them and stimulate immune cell responses (10,11). TLRs are involved in various immune system diseases, including AS, rheumatoid arthritis, osteoarthritis and autoimmune myositis (12–14).…”

Section: Introductionmentioning

confidence: 99%

Expression and function of Toll‑like receptors in peripheral blood mononuclear cells in patients with ankylosing spondylitis

Zhang

et al. 2019

Mol Med Report

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Ankylosing spondylitis (AS) is a common chronic inflammatory autoimmune disease. Toll-like receptors (TLRs) are involved in non-specific immunity. In the present study, the roles of TLRs in AS were investigated. The levels of inflammatory cytokines were detected by ELISA and reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The expression levels of TLRs and nuclear factor-κB (NF-κB) signaling-associated factors were determined via RT-qPCR and western blot analyses. It was observed that the levels of interleukin (IL)-6, tumor necrosis factor-α (TNF-α), C-reactive protein, TLR4 and TLR5 were increased in patients with AS, whereas those of IL-10 and TLR3 were decreased. Pomalidomide, a TNF-α release inhibitor, reduced the expression of IL-6, TNF-α, TLR4, TLR5 and phosphorylated-p65, and upregulated that of IL-10, TLR3 and p65 in peripheral blood mononuclear cells from patients with AS. Treatment of patients with infliximab, an anti-TNF-α monoclonal antibody, induced similar effects in vivo. In conclusion, it was revealed that inhibition of TNF-α suppressed inflammatory responses in patients with AS, increased the expression of TLR3 and decreased NF-κB signaling, and the expression of TLR4 and TLR5. The results indicated that TLRs and the NF-κB signaling pathway were involved in the regulation of inflammatory responses in AS. These findings provided insight into the mechanisms underlying the development of AS and potential novel therapeutic approaches.

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Section: Introductionmentioning

confidence: 99%

Expression and function of Toll‑like receptors in peripheral blood mononuclear cells in patients with ankylosing spondylitis

Zhang

et al. 2019

Mol Med Report

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“…Current pharmacological therapies and physiotherapies, such as regular exercise or spa therapy (36), mainly relieve the symptoms of AS (36). Dorothea et al reported that body hyperthermia treatment could increase IL-10 and toll-like receptor 4 expression which were believed to play an active role in the curative effect (37). In recent studies, blockade of PD-1 or Tim-3 molecules to restore the balance of immune regulation has been a hot topic (23,38).…”

Section: Cd8mentioning

confidence: 99%

The immune dysfunction in ankylosing spondylitis patients

Duan

Gui

et al. 2017

BST

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“…Clinical applications that require maintaining the temperature of tissue below certain threshold or within a range, such as in hypothermia for pain, trauma, inflammation management [11][12][13] or PCM-based hyperthermia treatments [14][15][16], could use an even more simple approach. If direct contact between PCM and skin is to be avoided, then the PCM could be packaged as a pad.…”

Section: Discussionmentioning

confidence: 99%

Passive cooling of cutaneous and subcutaneous tissues using phase changing materials: feasibility study using a numerical model

Romero‐Méndez

Pérez‐Gutiérrez

Musacchia

et al. 2017

International Journal of Hyperthermia

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In many dermatological applications, lowering the temperature of skin and maintaining specific temperatures for extended periods of time are fundamental requirements for treatment; for example, in targeting adipose tissue and managing cutaneous pain. In this work, we investigate the feasibility of using phase changing materials (PCMs) as an alternative passive, open-loop, heat extraction method for cooling cutaneous and subcutaneous tissues. We used a finite difference parametric approach to model the spatial and temporal progression of the heat transferred from the skin to a PCM in contact with the skin surface. We modelled the thermal performance of different PCMs, including different thicknesses. In addition, we used our model to propose application strategies. Numerical simulations demonstrate the feasibility of using PCMs for extracting heat from the skin and upper fat layers, inducing and maintaining similar temperatures as those induced by active closed-loop cooling with a cold plate. In terms of development, the critical design parameters are the temperature range of solidification of the material, the thickness of the material, and the rate of melting. Our study suggests that PCM-based devices may offer an alternative skin and adipose tissue cooling method that is simple to implement and use.

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Whole body hyperthermia treatment increases interleukin 10 and toll-like receptor 4 expression in patients with ankylosing spondylitis: A pilot study

Cited by 15 publications

References 30 publications

Expression and function of Toll‑like receptors in peripheral blood mononuclear cells in patients with ankylosing spondylitis

Expression and function of Toll‑like receptors in peripheral blood mononuclear cells in patients with ankylosing spondylitis

The immune dysfunction in ankylosing spondylitis patients

Passive cooling of cutaneous and subcutaneous tissues using phase changing materials: feasibility study using a numerical model

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