Whole-Body FDG PET/CT in Diagnosis of Internal Mammary Nodal Metastasis of Ovarian Carcinosarcoma

Chen, Yu‐Wen; Lin, Chia-Yang; Hou, Po-Nien; Lee, Chuan-Shiaw; Hou, Ming‐Feng; Tsai, Eing‐Mei

doi:10.1097/rlu.0b013e31820aa165

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…CT examination of patients with OMMMT found that most tumors showed unilateral large cystic solid masses with moderate or high enhancement, and the apparent diffusion coefficient of solid components was relatively high [ 29 ]. The PET/CT scan was useful for the detection of metastatic lesions, and a case of OMMMT patient who benefited from early detection of breast lymph node metastasis with PET was reported [ 31 ]. Researches suggested that CA125 was closely correlated with the prognosis of OMMMT patients [ 18 ], and study proposed that preoperative CA-125 levels exceeding 75 U/ml predicted a poor prognosis [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

The clinical characteristics and treatment of ovarian malignant mesoderm mixed tumor: a systematic review

Wang

Yao

et al. 2022

J Ovarian Res

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Background Ovarian malignant mesoderm mixed tumor (OMMMT) is a rare clinical entity. To provide reference for the treatment and prognosis of OMMMT, we analyzed the clinical features, pathology and molecular biology characteristic of published cases. Methods The English and Chinese reported cases of OMMMT were selected from PubMed, Clinical Trials.gov and CNKI database from 2000 to December 15th, 2021 following the PRISMA guidelines. Results A total of 63 literatures including 199 OMMMT cases were included. The average age of patients at diagnosis was 56.46 years, the highest incidence age was 60-65 years, and 82% of them were menopausal women. Most patients were diagnosed in FIGO III stage (59.64%). The most common symptom of OMMMT was abdominal pain (60.5%). 61.6% of patients were accompanied by ascites, while ascites was not associated with metastatic tumor and local recurrence. The CA125 of 88.68% patients increased. The most common reported carcinomatous component and sarcomatous component were serous adenocarcinoma (44.96%) and chondrosarcoma (24.81%), respectively. Initial treatment included surgery (94.97%) and taxanes-based (55.10%) or platinum-based (85.71%) chemotherapy regimens. The median survival time of patients was 20 months. Heterologous sarcoma component did not shorten life expectancy. The optimal ovarian tumor cell debulking surgery (OOTCDS), radiotherapy and chemotherapy could significantly prolong the median survival time of patients. Furthermore, platinum drugs could significantly prolong the survival time after comparing various chemotherapy schemes. Besides, the combination of platinum and taxanes was therapeutically superior to the combination of platinum and biological alkylating agents. Conclusion The OOTCDS and platinum-based chemotherapy regimen can improve the prognosis of OMMMT. Targeted therapy might become a new research direction in the future. Since the elderly patients are the majority, the toxicity of new drugs on the elderly patients is more noteworthy. Supplementary Information The online version contains supplementary material available at 10.1186/s13048-022-01037-6.

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Section: Discussionmentioning

confidence: 99%

The clinical characteristics and treatment of ovarian malignant mesoderm mixed tumor: a systematic review

Wang

Yao

et al. 2022

J Ovarian Res

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“…The earliest report of ovarian cancer metastasis to an IMN involved a 30‐year‐old woman with a stage I mucinous tumor (see Table ) . Since that report in 2000, eight articles have been published involving 23 additional women . Demographic, medical, and treatment characteristics of these women are summarized in Table to aid in comparing those cases to the one reported herein.…”

Section: Case Reports and Case Series Of Ovarian Cancer Metastases Tomentioning

confidence: 99%

Ovarian cancer metastases to internal mammary nodes

Harris

2019

Breast J

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FDG PET/CT in Sarcomatoid Carcinoma of the Gallbladder With Chondroid Differentiation

Dong

Wei²,

Zuo³

2016

Clinical Nuclear Medicine

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Sarcomatoid carcinoma of the gallbladder, composed of epithelial and sarcomatous components, is a rare malignant tumor with a poor prognosis. A 61-year-old man was admitted because of abdominal distention for 2 weeks. Enhanced CT showed a large gallbladder tumor with central necrosis. The tumor measuring 18 cm in maximum diameter showed intense peripheral FDG uptake with SUVmax of 15.4. The specimen of the resected tumor revealed tubular adenocarcinoma and sarcomatoid tissue with chondroid differentiation. Immunohistochemical staining showed the sarcomatoid tissue was positive for EMA, CD10, and VIM, with proliferation index of 80%. These pathologic findings were consistent with sarcomatoid carcinoma.

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Whole-Body FDG PET/CT in Diagnosis of Internal Mammary Nodal Metastasis of Ovarian Carcinosarcoma

Cited by 5 publications

References 9 publications

The clinical characteristics and treatment of ovarian malignant mesoderm mixed tumor: a systematic review

The clinical characteristics and treatment of ovarian malignant mesoderm mixed tumor: a systematic review

Ovarian cancer metastases to internal mammary nodes

FDG PET/CT in Sarcomatoid Carcinoma of the Gallbladder With Chondroid Differentiation

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