Whole-Body Bone Marrow MRI in Patients with Metastatic Disease to the Skeletal System

Steinborn, M.; Heuck, A.; Tiling, Reinhold; Bruegel, Melanie; Gauger, Laurie; Reiser, Maximilian

doi:10.1097/00004728-199901000-00026

Cited by 186 publications

(150 citation statements)

References 21 publications

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“…21,22 Planar bone scintigraphy has recently been compared with 18F PET bone studies by Schirrmeister et al in 44 patients with known prostate (20/44), lung or thyroid carcinoma. 23 The bone scans had a decreased sensitivity for detecting benign and malignant lesions in the bony pelvis compared with 18F PET bone scans.…”

Section: Discussionmentioning

confidence: 99%

The comparative values of bone marrow aspirate and trephine for obtaining bone scan-targeted metastases from hormone-refractory prostate cancer

Brown¹,

Doğan

Ell

et al. 2002

Prostate Cancer Prostatic Dis

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Samples of metastatic prostate cancer to bone are difficult to obtain. The aim of this study was to compare the results of bone marrow aspirate and trephine biopsy for obtaining metastatic hormone-refractory prostate cancer (HRPC) samples using previous diagnostic planar 99 m Tc-HDP bone scans to guide the procedure. All samples taken were for the purposes of research and molecular studies on HRPC. Twenty patients with HRPC had bone marrow aspirate and trephines taken from lesions in the posterior superior iliac spine or sacro-iliac region when shown on diagnostic 99 m Tc-HDP bone scans. Three patients also underwent plain X-ray, 18F-positron emission tomography bone scan, pelvic MRI scan and 99 m Tc nanocolloid bone marrow scans. These images were used to assess if the extra imaging information provided, such as three-dimensional localisation of the bone metastases, was of value for target bone metastases. Cancer cells were obtained in 15/20 (75%) cases in which a trephine biopsy was attempted and 0/20 of cases in which a bone marrow aspiration was attempted. The additional information provided by the range of other imaging investigations was of little benefit in obtaining tumour samples, but did suggest why negative biopsies were obtained in some cases after targeting with planar bone scans. We recommend the use of bone marrow trephine biopsy alone, guided by previous diagnostic 99 m Tc planar bone scan as a practical method to obtain prostate cancer cells from bone metastases. Keywords: 99 m Tc-bone scan; 99 m Tc-nanocolloid bone marrow scan; bone marrow aspiration; bone marrow trephine; Fluorine18 positron emission tomography bone scan; hormone-resistant prostate cancer; pelvic magnetic resonance imaging scan

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Section: Discussionmentioning

confidence: 99%

The comparative values of bone marrow aspirate and trephine for obtaining bone scan-targeted metastases from hormone-refractory prostate cancer

Brown¹,

Doğan

Ell

et al. 2002

Prostate Cancer Prostatic Dis

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show abstract

“…Therefore, MRI is playing an increasing role in the diagnosis of multiple myeloma [8]. Various authors have demonstrated the high sensitivity of MRI in detecting plasma cell infiltrations [2,6,7,[9][10][11][12]. In contrast to conventional skeletal X-ray surveys (X-ray survey), MRI can precisely evaluate the bone marrow.…”

Section: Introductionmentioning

confidence: 99%

Comparison of whole-body MR imaging and conventional X-ray examination in patients with multiple myeloma and implications for therapy

et al. 2008

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“…WB-MRI may have disadvantages in detecting metastatic lesions in the thoracic cage where motion artifacts of respiration and pulsation impair image quality [3,16,18]. In this study with added WB-DWI, there were 10 rib metastases and all WB-MRI readers detected all rib lesions.…”

Section: Discussionmentioning

confidence: 61%

Retrospective comparative study between 3T WB-MRI including WB-DWI and 18F-FDG-PET/CT in detection of metastatic disease

Tanaka¹,

Nakanishi²,

Ueda³

et al. 2017

Cancer Rep Rev

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Purpose: To retrospectively compare the diagnostic accuracy of 18F-FDG-PET/CT (PET-CT) and WB-MRI with WB-DWI (WB-MRI) in various types of metastatic diseases. Materials and methods:There were 26 patients who underwent WB-MRI and PET-CT within a period of one month. The WB-MRI protocols were: sagittal T1WI (Turbo Spin Echo) with TR/TE: 600/ 9.4 (msec), STIR with TR/ TE: 6000/85/240 (msec), coronal T1WI (FLASH) with TR/TE of 120/2.46 (msec) and axial DWI (b-0 and 800) based on STIR with TR/TE/TI of 14000/60/240 (msec). Three radiologists with various lengths of experience were assigned to review the WB-MRI images. The PET-CT reports were reviewed by radiologists with more than 10 years of experience in diagnostic PET-CT images. All patients had a follow-up of more than 6 months by MRI, computed tomography (CT) or PET-CT.Results: A total of 124 gold standard malignant lesions were identified. Regarding WB-MRI, the sensitivity was 68-78% (p=0.059-1.00) and the positive predicted value was 76-84%. With PET-CT, 98 lesions were detected correctly in total and the sensitivity and positive predictive values were 79% and 65%. Concerning only skeletal metastasis, the number of gold standard lesions was 80 in total. Regarding WB-MRI, the sensitivity was 85-93% (p=0.002-0.02) and the positive predicted value was 79-95%. With PET-CT, 61 lesions were detected correctly in total and the sensitivity and positive predictive values were 76% (61/80), 75% (61/81) respectively Conclusion: Although PET-CT and WB-MRI yielded similar overall results in detection of malignant lesions, the performance of WB-MRI in detection of bone metastasis was significantly higher.

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Whole-Body Bone Marrow MRI in Patients with Metastatic Disease to the Skeletal System

Abstract: Whole-body bone marrow MRI as used in this study is an effective method for evaluating the entire skeletal system in patients with suspected metastatic disease.

Cited by 186 publications

References 21 publications

The comparative values of bone marrow aspirate and trephine for obtaining bone scan-targeted metastases from hormone-refractory prostate cancer

The comparative values of bone marrow aspirate and trephine for obtaining bone scan-targeted metastases from hormone-refractory prostate cancer

Comparison of whole-body MR imaging and conventional X-ray examination in patients with multiple myeloma and implications for therapy

Retrospective comparative study between 3T WB-MRI including WB-DWI and 18F-FDG-PET/CT in detection of metastatic disease

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