Whole-body biodistribution and brain PET imaging with [18F]AV-45, a novel amyloid imaging agent — a pilot study

Whole-Body Biodistribution and Radiation Dosimetry of 18F-FP-(+)-DTBZ (18F-AV-133): A Novel Vesicular Monoamine Transporter 2 Imaging Agent

“…Serial WB scans were acquired on a Discovery ST16 PET/CT scanner (GE Healthcare) for all subjects. The details of image acquisition and processing have been described by our group (21). In brief, serial WB PET images were acquired in 3 scanning sessions after the intravenous injection of 18 F-AV-133 (390.8 6 22.9.0 MBq).…”

“…The details of image processing for dose estimation have been described by our group (21). In brief, volumes of interest were drawn on fused serial PET/CT images for the following organs: brain, thyroid, lungs, heart, liver, gallbladder, pancreas, kidneys, stomach, spleen, urinary bladder, intestine, lumbar spines, and where %ID(t), V organ , and M whole body are the %ID measured at time t after injection, the volume of the organ (cm 3 ), and the mass of the WB (g), respectively.…”

Diagnosis of Dementia Using Nuclear Medicine Imaging Modalities

“…2011;50:300-304) cognitively intact healthy subjects have increased tracer uptake (W. E. Klunk, et al, 2004;Mintun, et al, 2006;Morris, et al, 2009;Rowe, et al, 2007). Lin and co-workers presented similar results for [ 18 F]florbetapir in a clinical study, using 6 healthy controls and 3 AD patients (Lin, et al, 2010). Tracer uptake was particularly high in the frontal, parietal, and occipital cortices of AD patients; healthy controls showed substantial non-specific binding in subcortical white matter.…”

“…Moreover, [ 18 F]florbetapir has a good safety profile and biodistribution. The typical administered dose is 382.0±14 MBq (10.3±0.38 mCi), and the effective dose is 6.66±0.38 mSv using an administered dose of 370 MBq (whole-body effective dose conversion factor = 18.0±1.01 μSv/MBq) (Lin, et al, 2010 Figure 2) (Lister-James, et al, 2011). For example, in a study of 15 elderly healthy controls and 11 AD patients, [ 18 F]florbetapir uptake was significantly higher in AD patients than in healthy controls, especially in cortical target areas, such as the frontal and temporal cortices and the precuneus (Wong, et al, 2010).…”

SNMMI Procedure Standard/EANM Practice Guideline for Amyloid PET Imaging of the Brain 1.0

“…The radiation exposure from an amyloid PET study-at about 4-7 mSv-is within the range of commonly performed imaging studies. Radiation dosimetry estimates in humans have been evaluated in pilot studies for 18 F-florbetapir and 18 F-flutemetamol (13,14), as well as in the 18 F-florbetapir (15) and 18 F-flutemetamol clinical trials. Florbetaben dosimetry has been previously published (16).…”