Whole blood viscosity is associated with extrahepatic metastases and survival in patients with hepatocellular carcinoma

Han, Ji Won; Sung, Pil Soo; Jang, Jeong Won; Choi, Jong Young; Yoon, Shin Hee

doi:10.1371/journal.pone.0260311

Cited by 7 publications

(4 citation statements)

References 59 publications

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“…20 However, the aforementioned sensors were delivered to the targeted regions passively, which restricts the further applications, such as tumor diagnosis. Specifically, the viscosity of blood around lumps could be a symbol for detecting tumors, 21 but the lumps in deep regions, such as the base of skull, are hard to be accessed passively. The soft millirobot with active locomotion capability has been developed for sensing, 22 but the lack of deformability could hinder the movement of robot in confined environment.…”

Section: Introductionmentioning

confidence: 99%

Sensing of Fluidic Features Using Colloidal Microswarms

et al. 2022

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Sensing of key parameters in fluidic environments has attracted extensive attention because the physical features of body fluids could be used for point-of-care disease diagnosis. Although various sensing methods have been investigated, effective sensing strategies of microenvironments remains a major challenge. In this paper, we propose an approach that can realize sensing of fluidic viscosity and ionic strength using microswarms formed by simple colloidal nanoparticles. The influences of fluidic ionic strength and viscosity on two swarm behaviors are analyzed (i.e., the spreading of circular vortex-like swarms and the elongation of elliptical swarms). The data models for quantifying the fluidic viscosity and ionic strength are obtained from experiments, and the fluidic features can be sensed successfully using the swarm behaviors. Furthermore, we demonstrate that the microswarms have the capability of passing through tortuous and narrow microchannels for sensing. Continuous sensing of different fluidic environments using swarms is also realized. Finally, the sensing of viscosity and ionic strength of porcine whole blood is presented, which also validates the feasibility of the sensing strategy.

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Section: Introductionmentioning

confidence: 99%

Sensing of Fluidic Features Using Colloidal Microswarms

et al. 2022

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“…Similarly, high whole blood viscosity is associated with advanced stages of head and neck carcinoma ( Khan et al, 1995 ). Increased whole blood viscosity is also associated with extrahepatic metastasis and reduced survival of patients with hepatocellular carcinoma ( Han et al, 2021 ). Moreover, elevated plasma viscosity has been reported as an independent prognostic marker for the overall survival of breast cancer patients ( Han et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Increased whole blood viscosity is also associated with extrahepatic metastasis and reduced survival of patients with hepatocellular carcinoma ( Han et al, 2021 ). Moreover, elevated plasma viscosity has been reported as an independent prognostic marker for the overall survival of breast cancer patients ( Han et al, 2021 ). Thus, the role of physiologically relevant extracellular fluid viscosity in cancer cell migration and metastasis should be urgently investigated.…”

Section: Introductionmentioning

confidence: 99%

The interplay between physical cues and mechanosensitive ion channels in cancer metastasis

Bera

Kiepas

Zhang

et al. 2022

Front. Cell Dev. Biol.

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Physical cues have emerged as critical influencers of cell function during physiological processes, like development and organogenesis, and throughout pathological abnormalities, including cancer progression and fibrosis. While ion channels have been implicated in maintaining cellular homeostasis, their cell surface localization often places them among the first few molecules to sense external cues. Mechanosensitive ion channels (MICs) are especially important transducers of physical stimuli into biochemical signals. In this review, we describe how physical cues in the tumor microenvironment are sensed by MICs and contribute to cancer metastasis. First, we highlight mechanical perturbations, by both solid and fluid surroundings typically found in the tumor microenvironment and during critical stages of cancer cell dissemination from the primary tumor. Next, we describe how Piezo1/2 and transient receptor potential (TRP) channels respond to these physical cues to regulate cancer cell behavior during different stages of metastasis. We conclude by proposing alternative mechanisms of MIC activation that work in tandem with cytoskeletal components and other ion channels to bestow cells with the capacity to sense, respond and navigate through the surrounding microenvironment. Collectively, this review provides a perspective for devising treatment strategies against cancer by targeting MICs that sense aberrant physical characteristics during metastasis, the most lethal aspect of cancer.

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“…Most microfluidic-based cancer-on-a-chip models use buffers to simulate the interstitial flow of the blood stream, which are very different from the physiological condition, such as the rheology of the blood. Whole blood viscosity positively correlates with the cancer stage and metastases [70][71][72][73]. Thus, the blood viscosity should be taken into consideration before flowing into the cancer chips.…”

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confidence: 99%

Cancer-on-a-Chip: Models for Studying Metastasis

Zhang

Karim

Hasan

et al. 2022

Cancers

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The microfluidic-based cancer-on-a-chip models work as a powerful tool to study the tumor microenvironment and its role in metastasis. The models recapitulate and systematically simplify the in vitro tumor microenvironment. This enables the study of a metastatic process in unprecedented detail. This review examines the development of cancer-on-a-chip microfluidic platforms at the invasion/intravasation, extravasation, and angiogenesis steps over the last three years. The on-chip modeling of mechanical cues involved in the metastasis cascade are also discussed. Finally, the popular design of microfluidic chip models for each step are discussed along with the challenges and perspectives of cancer-on-a-chip models.

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Whole blood viscosity is associated with extrahepatic metastases and survival in patients with hepatocellular carcinoma

Cited by 7 publications

References 59 publications

Sensing of Fluidic Features Using Colloidal Microswarms

Sensing of Fluidic Features Using Colloidal Microswarms

The interplay between physical cues and mechanosensitive ion channels in cancer metastasis

Cancer-on-a-Chip: Models for Studying Metastasis

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