Whole blood transfusion in the treatment of an acute organophosphorus poisoning – a case report

Ryniak, S.; Harbut, Piotr; Goździk, Waldemar; Sokołowski, Janusz; Paciorek, Przemysław; Hałas, Joanna

doi:10.12659/msm.881922

Cited by 12 publications

(8 citation statements)

References 12 publications

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“…Research has shown that the major mechanism of organophosphorus pesticide poisoning is the inhibition of organic phosphorus acting on cholinesterase. This inhibition leads to a large accumulation of acetylcholine in the tissue space, which further results in a series of dysfunctions in the nervous system, myocardial cells, and respiration (3,4). Severe AOPP can cause acute cholinergic crisis, including the stimulation of nicotinic receptors and muscarinic receptors, which leads to the main cause of death, namely respiration failure (5).…”

Section: Introductionmentioning

confidence: 99%

Application of hemoperfusion in severe acute organophosphorus pesticide poisoning

Li¹,

Wang²,

Zhen³

et al. 2017

Turk J Med Sci

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The aim of this research is to investigate the clinical efficacy of hemoperfusion in the treatment of severe acute organophosphorus pesticide poisoning (AOPP). Materials and methods:Patients meeting the inclusion criteria were divided into Groups 1 and 2 according to whether hemoperfusion was applied or not. Group 2 was observed as the control group. Conventional therapy for AOPP was given to Groups 1 and 2. Besides conventional treatment, patients in Group 1 were also treated with hemoperfusion therapy. Cholinesterase activity and blood glucose concentration were tested before hemoperfusion and for the first 3 days afterwards. The recovery time of 50% cholinesterase was recorded. At the same time, the incidence and mortality of intermediate syndrome was observed and compared. Results:The incidence and mortality of intermediate syndrome in Group 1 was obviously decreased, and the recovery time of cholinesterase activity was significantly shortened compared with Group 2. Conclusion:Hemoperfusion, used for treating severe AOPP, contributes to the improvement of cholinesterase activity, low incidence and mortality of intermediate syndrome, and increase in curative rate.

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Section: Introductionmentioning

confidence: 99%

Application of hemoperfusion in severe acute organophosphorus pesticide poisoning

Li¹,

Wang²,

Zhen³

et al. 2017

Turk J Med Sci

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“…Previous studies have reported whole blood transfusion [9] or fresh frozen plasma transfusion [14] could restore the enzymatic function by its biscavenging effect. However, packed RBCs transfusion has advantages over whole blood transfusion, since the total volume administrated into patients is less that could avoid risks of overloading and fever or allergy by substances in serum.…”

Section: Discussionmentioning

confidence: 99%

“…OP intoxications are potentially fatal poisonings which result from both accidental and purposeful intake. These poisoning could be acute or chronic, with high risk of remote consequences [9]. OP compounds are very strong inhibitors for carboxylic ester hydrolases.…”

Section: Discussionmentioning

confidence: 99%

Fresh Red Blood Transfusion as a Successful Erythrocyte Cholinesterase Supplement in Organophosphate Poisoning

Wang¹,

Huang²,

Chen³

et al. 2016

J Clinic Toxicol

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Despite improvements to standard treatments (atropine, oxime) and intensive care management, the mortality associated with organophosphate (OP) poisoning has not substantially decreased. In this study, we evaluated the role of packed red blood cells (RBCs) transfusion in acute OP poisoning. Patients diagnosed with OP poisoning were included in this prospective study, and then were transfused with packed RBCs stored less than 10 days or 10 to 35 days. Cholinesterase (ChE) level in blood, atropine usage and durations were recorded. We found both shorter-and longer-storage RBCs (200~400 ml) significantly increased AChE level in blood, improved ChE recovery, and reduced the usage and shortened the duration of atropine and followed clinical recovery. Shorter-storage RBCs had better effect than longer-storage (longer storage) ones. Due to erythrocyte cholinesterase supplement, packed RBCs might be used as an alternative approach in patients with OP poisoning, especially at the early stages.

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“…OPs like DZN exert their detrimental effects through oxidative stress, oxidation of lipids, proteins and DNA in the testis [43]. Ahmed and et al reported that administration of ginger with biological activities improves sperm parameters [32].…”

Section: Discussionmentioning

confidence: 99%

Zingiber officinale mitigates diazinon-induced testicular toxicity via suppression of oxidative stress and apoptosis in mice model

Beklar¹,

Hamzeh²,

Karimpour³

et al. 2019

jrp

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Whole blood transfusion in the treatment of an acute organophosphorus poisoning – a case report

Cited by 12 publications

References 12 publications

Application of hemoperfusion in severe acute organophosphorus pesticide poisoning

Application of hemoperfusion in severe acute organophosphorus pesticide poisoning

Fresh Red Blood Transfusion as a Successful Erythrocyte Cholinesterase Supplement in Organophosphate Poisoning

Zingiber officinale mitigates diazinon-induced testicular toxicity via suppression of oxidative stress and apoptosis in mice model

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