Whole blood thrombelastographic coagulation profiles using minimal tissue factor activation can display hypercoagulation in thrombosis‐prone patients

Abstract

In future studies with ex vivo dose titration assessment of pro-coagulant components mixed with blood from a patient suffering from compromised haemostasis, observation of a significantly shortened clot initiation concomitant with a distinctly accelerated clot propagation is likely to indicate an increased risk of thrombosis.

Whole blood coagulation assessment using rotation thrombelastogram thromboelastometry in patients with acute deep vein thrombosis

“…No differences in clotting time were found in patients as compared with controls in all assays. This is in contrast with previous observations in DVT patients [12]. This might be explained by a different selection of patients (nonacute phase DVT) or different methods used (tissue factor reagent concentration etc.)…”

“…Larger studies are needed to clarify this point. It is interesting to note that in previous observations dealing with patients with a personal history of DVT, ROTEM performed several months after the acute DVT failed to present significant differences in several parameters [12]. Even though this study provides some information on thromboelastometry in the acute phase of DVT, no data are presently available on the follow-up of patients.…”

“…Moreover, ROTEM has been shown to be a point of care device for rapid diagnosis in various bleeding disorders [7][8][9] and for global assessment of coagulation status in patients with hypercoagulable conditions [10,11]. With regard to venous thromboembolism (VTE), Hvitfeldt Poulsen et al [12] showed that patients with a previous history of venous or arterial thromboembolic event had some ROTEM parameters consistent with hypercoagulability as compared with healthy controls. However, no information is presently available on the use of ROTEM during the acute phase of VTE in which a (transient) hypercoagulable state also related to increased levels of fibrinogen and factor VIII has been observed.…”

Normal range values for thromboelastography in healthy adult volunteers

“…In the past it was criticized for being too dependent on manual procedures and for its results being excessively operator dependent (8,(17)(18)(19)(20)22,23,30,31). However, the recent development of computerized interfaces has addressed some of these limitations and has led to a renewed interest in TEG ® , particularly to guide blood transfusion practices (7,22,31). Our original goal, however, was not to evaluate the reliability of TEG ® as a laboratory test per se, but rather its potential clinical application in trauma care.…”

Association of Haemostasis Activation Markers with Thrombophilia and Venous Thromboembolism

“…TEG showed a marked hypercoagulable profile in patients with acute VTE (Spiezia et al, 2008). Also in patients with a history of venous or arterial thrombosis, shorter clotting times and accelerated maximum velocity of clot propagation were measured (Hvitfeldt Poulsen et al, 2006). However, another study in patients with a history of cerebral vein thrombosis did not confirm these results (Koopman et al, 2009).…”